Laktionet

Highly effective contraceptive Lactitone is produced by the Hungarian company OAO Gedeon Richter. 

Indications Laktionet

Lactitet is a means of oral contraception.

Release form

Form Lactinet - tablets, convex on both sides of a round shape. The surface of the tablet is clad with a protective film of white color. On one side there is an alphabetic symbol "D", the other side has a digital image - "75".

Tablets are sealed to 28 pieces in a blister pack. Three such blisters are packed in a cardboard box along with the instructions.

The active substance of the drug is desogestrel. One tablet of the drug Lactineth contains 0.075 g of active ingredient.

Other chemical compounds of the preparation: L-tocopherol, colloidal silicon dioxide, α-tocopherol, lactose monohydrate, stearic acid, potato starch, D-tocopherol, magnesium stearate and povidone K30.

Protective outer layer of the tablet is represented by such substances: polyvinyl alcohol, titanium dioxide, macrogol 3000, opiate II white and talc.

Pharmacodynamics

Laktionet is a hormonal drug whose active chemical is dezogestrel and progestogen.

Laktinet can be safely taken by women, who are categorically contraindicated in dosage forms with estrogen-containing components.

Desogestrel effectively inhibits the process of ovulation. Against the background of taking a gestagen contraceptive, the ovulatory follicle is not formed. It is not observed in the blood and growth level of progesterone and luteotropic hormone, which must be present in the middle of the natural course of the menstrual cycle.

In this case, the active substance acting on the mucous membrane of the cervix increases its density, which becomes a barrier to the penetration of spermatozoa into the uterus.

On the background of therapy with Lactineth, the percentage of conception was only 0.4%.

Lactineth allows to reduce the level of estradiol in the blood plasma to the values close to the values of the early follicular period. There is an improvement in lipid and carbohydrate metabolism.

Desogestrel is transformed into ethonogestrel metabolite, due to dehydrogenation and hydroxylation processes.

Etonogestrel is also metabolized to sulfate and glucuronide conjugates.

[1], [2], [3], [4], [5], [6], [7]

Pharmacokinetics

Lactineth is actively absorbed by the mucosa of the gastrointestinal tract. On average, the greatest amount of active desogestrel in the plasma can be observed after 1.8 hours from the time of oral administration.

Laboratory and clinical studies have shown that the bioavailability of etonogestrel is 70 percent.

Up to 99% of it is combined with the placental blood protein.

On average, the half-life of the active ingredient Lactitet is about 30 hours. This indicator is unchanged, whether it is a single use or long-term use of the drug. A stable balance of the hormonal balance in the patient's body is established after four to five days.

The excretion of the components of the drug and their metabolites occurs both through the kidneys along with the urine (about 3/5 of the amount), as well as through the intestine with calves (2/5 of the amount). 

Dosing and administration

It should immediately be stipulated that any medication, including Lactitone, is prescribed and prescribed only by a qualified experienced specialist. Pharmacologists offered only the recommended method of administration and dose, and a more specific schedule of administration and dosage adjustment remains with the treating specialist.

Initially, the drug in question was developed for oral administration, squeezed with a sufficient volume of fluid. If a woman has not taken other contraceptive preparations during the previous 30 days, then the medicine starts to drink one unit a day. And this first technique is recommended to be combined with the first days of the menstrual cycle. To obtain maximum physiological efficiency, obstetrician-gynecologists recommend that the patient take the pill every time at the same time of the day, observing the time interval between two tablet taking exactly 24 hours.

If the tablets of one package are over, it is worthwhile to follow to prevent a break in taking the drug. The next day, you need to go to another medication package.

It is not recommended to use parallel to other contraceptive methods and techniques when using the drug described in this article.

If it so happens that the first reception of birth control pills occurred within the second - fifth days of the menstrual cycle, which is allowed by doctors, then during the first week (seven days), other measures to prevent pregnancy should be taken tandem. 

If a woman wants to switch to Lactitone after using another contraceptive for oral use, then no problems should arise. The intake of the preliminary preparation ends and the next day at the same time, the transition to treatment with the contraceptive considered in this article begins. In this situation, it is not necessary to take additional measures to maintain contraceptive characteristics.

If the transition to the drug described in this article occurs after the application of other contraceptive methods (monocomponent progestogen-containing contraceptives), it is recommended to start taking the medication:

• If the predecessors were contraceptive injections, from the day of the last injection.
• After removal of the implant, a new oral contraceptive is first introduced the next day after removal.
• With the preliminary use of minipills, you can start taking medication from any point in time.

But in any scenario it is necessary to use additional barrier methods of protection during the first seven days of the transition.

Specific features of the drug in question are available when the drug is administered during the postpartum period and after the abortion:

1. If getting rid of the embryo took place against the background of the first trimester of pregnancy, then Laktionet can be taken immediately after the operation. In this case, additional measures of protection are not required.
2. In case of childbirth or late termination of pregnancy, against the background of the second trimester of bearing the fetus, the oral contraceptive is allowed by the physicians to be administered only three to four weeks after the event. In the case of a later onset of protection, experts recommend the first week (seven days) in parallel with Lakintet apply barrier method of protection.
3. If there was unprotected sex before the first pill that was taken, it is necessary to make sure that there is no conception or to postpone taking the drug in question until the first day of the next menstrual cycle.

If one of the tricks was missed, but the interval between two tablets taken is less than 12 hours, you should immediately drink a pill and drink the next day at the usual time, continuing the schedule. If 36 hours is exceeded, the therapeutic effectiveness of protection is markedly reduced, and the reception schedule should start from scratch.

If the break is more than 12, but less than 36 hours, but the next seven days, together with Lakintet should use and auxiliary types of contraception.

If you forgot to drink a pill in the first seven days of "treatment," while in this period there was an unprotected sexual intercourse, you need to make sure that there was no conception. And only according to the results of the survey can we talk about further activities.

If a woman begins to vomit after three to four hours after the pill is taken, consult your doctor. Perhaps, there is an underestimation of the intensity of absorption and a woman needs to behave as if she missed a reception.

[12]

Use Laktionet during pregnancy

Use during pregnancy hormonal contraceptive Lactitone is prohibited.

Taking this medication, especially at high dosages, is able to influence the development of the fetus. Pathological changes mainly affect embryos of the female genus, later their development begins to follow the path of musculation due to the action of the progestogen, which is part of the drug.

Etonogestrel freely penetrates into the mother's milk. And, consequently, falls into the body of the newborn. The quantitative ratio of the concentration of etonogestrel in the blood plasma and in milk is 0.87 to 0.55.

Monitoring of breastfed babies whose mothers took Lactineth did not show any changes. 

Contraindications

Contraindications for the use of Lactitone are as follows:

1. Severe liver pathology.
2. Liver dysfunction in anamnesis.
3. Venous thromboembolism. Including pathological changes in the pulmonary arteries, deep vein thrombosis in the legs.
4. Diagnosed malignant neoplasm in the liver.
5. Malignant lesion of the mammary gland.
6. Glucose - galactose malabsorption.
7. Diagnosis of other cancer hormone-dependent neoplasms.
8. Vaginal bleeding of unknown cause.
9. Deficiency of lactase or intolerance to it.
10. Continuous immobilization.
11. Postoperative period, surgical intervention.
12. Pregnancy.
13. Increased individual intolerance to one or more of the components of Lactineth.

Prescribe a protocol of treatment, but with extreme caution should the hormonal contraceptive, if the patient's history is:

1. Hyperpigmentation of facial skin. Especially if it manifests itself after conception and bearing of the fetus.
2. Herpes.
3. Resistance form of hypertension (persistent increase in blood pressure).
4. Diabetes mellitus in the anamnesis.
5. Porphyrin disease.
6. Systemic lupus erythematosus.

[8], [9], [10]

Side effects Laktionet

Taking Lactanet can cause some side effects. Most often it is necessary to meet with such pathological symptoms:

1. Violation of the menstrual cycle: abundant or scanty menstruation.
2. Occurrence of acyclic spotting blood extracts. This fact is noticed in almost half of women who take Lactineth.
3. Every 3-5 women experience a contraction of the menstrual cycle.
4. One out of every five notes that the monthly ones have become more scarce or have ceased to go completely.
5. There are cases when the menstrual cycle, on the contrary, lengthened.

The following pathological symptoms may also occur:

1. Dizziness.
2. Weight gain.
3. Nausea.
4. Acne, acne.
5. Emotional instability.
6. Soreness in the mammary glands.
7. Headache
8. Decreased libido.

It is rare to observe the following side effects:

1. Alopecia.
2. Vomiting.
3.  Exacerbation of vaginitis or cystic ovaryectomy.
4.  Dysmenorrhea.
5.  Decrease in the general tone of the body.
6.  Appearance of symptoms of an allergic reaction to the drug Laktionet:

• Hyperemia of the skin.
• The appearance of a rash.
• Itching.
• Hives.
• Nodular erythema.

The use of desogestrel can provoke the development of cholelithiasis, exacerbation of herpes, cholestatic jaundice, otosclerosis, hearing loss, hemolytic uremic syndrome, as well as chorea (the appearance of random unregulated movements).

Do not forget that oral contraception does not protect a woman from sexually transmitted diseases and AIDS.

[11]

Overdose

Overdose Lactinet is capable of manifesting such pathological symptoms:

1. Nausea.
2. Vomiting.
3. Increased blood levels.
4. Vaginal bleeding.

At the moment, there is no ideal antidote to such a situation. Therapy is especially symptomatic, or the drug is replaced with another analogue.

[13], [14], [15],

Interactions with other drugs

With the simultaneous administration of Lactitone with inducers of microsomal liver enzymes, the contraceptive in question significantly reduces its pharmacological properties, and uterine bleeding can also be provoked.

The inducers of microsomal liver enzymes include: rifampicin, primidone, oxcarbazepine, phenytoin, griseofulvin, barbiturates, carbamazepine, rifabutin, hydantoin derivatives, topiramate, felbamate.

If you take Lactitone against the background of treatment with systemic antibiotics, there is a decrease in the effectiveness of birth control pills. Therefore, during the period of antibacterial therapy (and then the next seven days, for rifampicin this period is 28 days), a barrier method of contraception should also be introduced.

Adsorbents (activated charcoal) impair the absorption of Lactitet. 

[16]

Storage conditions

The requirements for storage conditions of Lactiton are as follows:

1. Store the medicine in a dark place, in places that are not available for adolescents and small children.
2. Temperature storage should not be above +25 degrees.

Shelf life

The shelf life of the hormonal contraceptive Lactitet is three years (or 36 months).