Febrofide

Fibrofide is an analgesic and anti-inflammatory agent used topically.

Indications Febrofide

Phybofide is indicated for local anesthesia, as well as anti-inflammatory action for pains in the spine, neuralgia, myalgia, inflammatory-degenerative processes in the musculoskeletal system, arthritis, bursitis, synovitis, tendinitis, lumbago. It is also good to use a medicine to treat problems that cause sports injuries, sprains or tears of ligaments and tendons, dislocations, bruises, and especially with post-traumatic pain sensations.

Release form

Medicinal product Fеbofid is available in the form of a gel that is colorless or light yellowish, of a transparent consistency. The drug is packaged in aluminum tubes of thirty or fifty grams of gel in each and packed in a cardboard box, equipped with an insert instruction. A hundred grams of the gel contains ketoprofen lysine salt - two and a half grams, as well as a certain amount of excipients - polyethylene glycol, methylhydroxyenzoate, propylhydroxybenzoate, carbomer, triethanolamine, purified water.

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Pharmacodynamics

Fibrofide is an analgesic and anti-inflammatory agent used topically. The gel has a therapeutic effect on the joints, muscles, tendons, ligaments, skin, veins, lymphatic vessels and lymph nodes. This reduces pain, and increases the mobility of limbs in a state of rest and movement. Also, morning stiffness, as well as swelling of the joints, is reduced.

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Pharmacokinetics

Febrofid differs qualities of good penetration through integuments. The percentage of bioavailability of the drug is about fifty. The absorbed amount of the active ingredient is able to bind to serum proteins in almost one hundred percent of cases. Ketoprofen is metabolized in the liver. Approximately eighty percent of the amount of active substance used can be excreted in the urine in the state of metabolites, about ten percent of the substance remains unchanged and in the same way is output. Does not have the ability to accumulate in the body.

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Dosing and administration

Fibrofide is an external remedy. Gel in the amount of three to five centimeters is applied to the desired area of the skin and rubbed with light movements. This procedure should be repeated from two to three times a day. Applying a bandage is not necessary, since such an action will not enhance the effectiveness of the drug. The course of treatment is determined by a specialist.

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Use Febrofide during pregnancy

Medication Fibrofid is contraindicated for use in the third trimester of pregnancy. In the first and second trimesters of pregnancy, the drug should be used only because of extreme necessity. During lactation, breastfeeding should be interrupted for the duration of treatment with the drug.

Contraindications

• The presence of hypersensitivity to ketoprofen or other substances that are part of the drug.
• The existing sensitivity to other non-steroidal anti-inflammatory drugs, as well as to acetylsalicylic acid.
• Presence of wet dermatoses, eczema, infected abrasions, wounds and burns.

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Side effects Febrofide

• Allergic reactions - itching and burning of the skin, redness and flaking, symptoms of hyperemia in the treated area.
• The appearance of the reaction of photosensitization, as well as skin exanthema and purpura.

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Overdose

There is no evidence of an overdose of Febrofide.

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Interactions with other drugs

With prolonged use of the drug, Febrofide, there may be signs of interactions and other drugs. The same applies to cases of frequent use of the drug.

Simultaneous use of the drug and other non-steroidal anti-inflammatory drugs stimulates the appearance of stomach ulcers, as well as the development of bleeding from the gastrointestinal tract. Similar problems arise with the combined use of ethanol, corticotropin and glucocorticosteroids.

With the simultaneous administration of oral anticoagulants, heparin, thrombolytic agents, antiaggregants, cefoperazone, cefamandol, the possibility of bleeding increases.

Hypotensive drugs and diuretics reduce their effectiveness under the influence of active substances of the drug.

Co-administration leads to an increase in the hypoglycemic action of insulin. The same effect is different and hypoglycemic drugs in combination with the drug.

Valproate sodium, prescribed in combination with the drug, leads to a violation of platelet aggregation. In the blood, there is an increase in substances such as verapamil and nifedipine.

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Storage conditions

Fibrofide - it is important to store at a temperature of fifteen to twenty-five degrees Celsius, in a place that is not accessible to children.

Shelf life

Fibrofide - twenty four months from the date of production.