Factual

Fact is a drug from the spectrum of antibiotics. One of the main active substances is hemifloxacin. The factor belongs to the group of fluoroquinolones. It is an antibacterial medication that has bactericidal activity - destroying various forms of bacteria in the body, which contributes to the healing process. The action of the drug extends to the following groups of microorganisms: Gram-positive and Gram-negative, anaerobic and aerobic, atypical. Due to this, treatment can occur with any disease, regardless of the group of pathogens.

Another important active substance - hemifloxacin - will help you overcome the resistance that could occur when taking other antibiotics. 

Facial medicine has a second, non-proprietary name - Gemifloxacin (by name of the active substance).  

Indications Factual

The medication should be used in case of infectious and inflammatory diseases that were caused by sensitivity to hemifloxacin by other microorganisms. Indications for taking medication apply to the treatment of the following diseases: complications or exacerbation of chronic bronchitis, acute inflammation of the lungs, which was caused by polysuristant microbes, as well as with acute sinusitis. 

The medication is forbidden for admission by patients who have not reached the age of 18.

[1], [2], [3], [4]

Release form

Drug medication Fact is released in the form of pills and tablets. The pills are in the shape of an elongated oval, covered with a film of white or grayish color on top. Each tablet contains a dosage of the treating drug of 320 milligrams. Also, the separating strips are placed on the pill on each side.

In the modern pharmacy market, only 5 or 7 tablets are available for sale in cardboard packages. 

Pharmacodynamics

Since hemifloxacin is a preparation against microbes by a representative of a group of fluoroquinolones. The substance has a strong effect on harmful bacteria and on various groups of microorganisms. The active ingredient Faktiva violates those harmful processes that inhibit the formation of enzymes, which are necessary for the growth of beneficial bacteria in the body. Gemifloxacin is highly related to bacterial topoisomerases II (DNA-gyrase) and IV. 

The mechanism of action on various fluoroquinolones, including hemifloxacin, differs from various beta-lactam antibiotics. 
In the pharmacodynamics of Fakiva, there was no cross-reactivity between hemifloxacin and other different antibiotics from other groups. 
The substance of hemifloxacin is active in the fight against a large number of microorganisms that arise in the body in various diseases. 

[5], [6], [7], [8], [9], [10],

Pharmacokinetics

Pharmacokinetics of the drug Factive has the principle of linear action, when it enters the body. The medication is taken orally in the body in a dose calculation of 40 to 640 mg.
The factor is rapidly absorbed into the gastrointestinal tract.
The time interval, the amount of food intake in no way can affect the pharmacokinetics of Faktiv, therefore, these tablets are allowed regardless of the time of ingestion.
At repeated reception, Factive is associated with plasma. The percentage that binds does not depend on various indicators, for example - age ..
The concentration of the active substance hemifloxacin in the bronchi is higher than in the blood plasma, so it quickly penetrates into the lung tissue.
In a small amount, the medication can be collected in the liver. After three hours after taking the drug, it predominates over metabolites in the blood plasma.
Fact is excreted through the intestine and with urine.
At the moment there are no any data on the pharmacokinetics in children under 18 years old.  

[11], [12], [13], [14], [15], [16]

Dosing and administration

The factor is taken orally, without chewing, squeezed with enough water. Depending on the disease, the way of application and the dose of the drug in the course of treatment can be as long as five days, and increase up to a week. The average recommended dose of the drug is one tablet (320 mg) per day, regardless of the time of ingestion.

In the case of pneumonia, the Factive is used for a week once a day. If the symptoms of bronchial asthma worsen, the course lasts five days. The same amount of time is spent treating acute sinusitis.  

But with a possible kidney disease and other types of disruption of the genitourinary system, possible renal failure, the dosage is reduced exactly twice - 160 mg once a day. 

The fact is not recommended for children who have not yet reached the age of eighteen. Also, avoid taking the drug during pregnancy and lactation. 

[26], [27], [28], [29], [30]

Use Factual during pregnancy

The use of Faktiva during pregnancy and lactation is strictly prohibited. At the moment, there is no information about the studies of the use of the Factot drug during pregnancy of women.

In case of acute need to take the drug during lactation, it is necessary to stop breastfeeding until the end of the course. 

Contraindications

It should be refrained from taking Fativa with sensitivity and hypersensitivity to hemifloxacin and various fluoroquinolones. For those who have the risk of lengthening the interval on the electrocardiogram, the drug should be reduced or temporarily discontinued. Also, you should avoid taking the drug if you have damage to the tendons that are formed due to the use of various fluoroquinolones.

It is necessary to take the Factive with the high degree of caution and under the strict supervision of the attending physician the following groups:

• Those with a risk of arrhythmia;
• Those who have increased development of the hemolytic reaction;
• To those who take various steroids;
• Those who are sick with epilepsy and who are prone to seizures;
• Those who have symptoms of hypokalemia and hypomagnes.

Before prescribing the drug and starting its administration, tell your doctor about all other medications that you are taking.

[17], [18], [19], [20], [21]

Side effects Factual

In the treatment of the Factul drug, the following side effects may occur:

• Manifestation of skin allergy, namely - itching of the skin;
• There may be attacks of nausea or diarrhea, vomiting reflexes, fits of meteorisms. In rare cases - attacks of acute hepatic insufficiency;
• Rarely, due to the action of one of the constituents of the medicine, side effects can manifest as attacks of anxiety, anxiety;
• In the case of occasions - there may be a violation of taste sensations and feelings of perception of the surrounding world.

In isolated cases, symptoms of leukopenia, thrombocytopenia, pancytopenia and other hematologic disorders are possible. Also, crystalluria and attacks of pain that occur as a result of renal insufficiency, a sharp increase in the sodium content or a drop in potassium are rare.

It is possible to reduce the calcium content, the content of neutrophils in the blood decreases, the level of hepatic transmemax increases. 

[22], [23], [24], [25]

Overdose

Overdose of the drug is detected in case of increased side effects. In this case, it is necessary to carry out symptomatic treatment, since there is no specific antidote for Counteracting Fact.

At the first manifestations of an overdose of the drug, it is necessary to wash the stomach - after drinking a large amount of water or induce vomiting, to purify the stomach of the rest of the drug. In the future, it is necessary to continue to drink water in large quantities and be under constant monitoring by the doctor in charge.

In particularly severe cases, it may be necessary to conduct hemodialysis (for deep purification of blood in the body).

[31], [32], [33], [34], [35], [36]

Interactions with other drugs

With the simultaneous treatment of antacids and hemifloxacin, a decrease in the level of various trace elements, for example, aluminum and sulphate, is possible. Therefore, it is recommended to use antacids three or four hours before the fact is accepted.

With simultaneous administration with sucralfate, it is possible to reduce the bioavailability of hemifloxacin. Therefore, the reception of these drugs should be delineated no less than two hours.

If reception of oral contraceptives takes place, there may be a slight decrease in the bioavailability of hemifloxacin.

The factor has no effect on the effect of levonorgestrel contraceptives.
 

[37], [38], [39]

Storage conditions

It must be stored in a dark, dry, well-ventilated place. Storage temperature should not exceed 25 ° C. The storage conditions for the Factus product should include full protection from children and domestic animals. If the drug is not used immediately after purchase, it is recommended not to open the package and blisters, so as not to shorten the shelf life of the drug. 

[40]

Special instructions

Analogs of Factors

Considering the group of fluoroquinolones by the coincidence of the active substance of antibacterial action, the following analogs exist: Fatadine: Furadonin, Lactobacterin dry, Pansef, Enterofuril, Ersefuril, Furacilin, Sextafag, Clacid, Biolarox and Bactrim.

[41], [42], [43], [44], [45], [46],

Shelf life

Shelf life is three years from the date of manufacture. With proper storage conditions, you can take the drug without fear, until the expiration date.

But if the conditions for storage of the drug or the integrity of the package have been violated, the shelf life is significantly reduced. 

 

[47],