Rabifin

Rabbitin - a drug used to treat diseases of the gastrointestinal tract. Consider who is prescribed Rabifin, features and directions for its use.

The pharmacological group of medicine is a remedy for the treatment and prevention of peptic ulcer, gastroesophageal reflux disease and other pathologies on the part of the digestive and gastrointestinal tract. Rabifin refers to inhibitors of the proton pump.

Rabifin is a proton pump drug used for the treatment and preventive treatment of diseases of the digestive system. The medicine is released only on the prescription.

Indications Rabifin

Rabbitin is the treatment and prevention of such diseases as:

• Duodenal ulcer
• Stomach ulcer
• Gastroesophageal reflux disease
• Not ulcerative indigestion
• Chronic gastritis with increased acid-forming function of the stomach (in the stage of exacerbation)
• Eradication of Helicobacter pylori (with combined therapy with antibacterial agents)
• Zollinger-Ellison syndrome.

Before starting the procedure, the patient should be checked for any malignant neoplasms. Patients with oncology do not prescribe this medication. If tablets are attributed to patients with impaired renal and hepatic function, special care should be taken in the early stages of therapy. The drug is not prescribed to children of childhood, as today there is no experience of its use in this age category.

[1], [2], [3], [4]

Release form

The tablet form of release simplifies the process of application, since the patient has the opportunity to calculate the necessary dosage and the number of doses. The international name of the pharmaceutical is rabeprazole.

Basic physical and chemical properties: tablets of yellow color, round in shape, with a dissolution in the stomach and a smooth facet. 1 capsule may contain 10 or 20 mg of active ingredient. As auxiliary substances are: magnesium oxide, microcrystalline cellulose, titanium dioxide, mannitol, hydroxypropylmethylcellulose and other components.

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Pharmacodynamics

Pharmacodynamics Rabifin indicates that Rabifin belongs to the class of antisecretory compounds, that is, to the substitutes for benzimidazole. The drug has no anticholinergic properties, but inhibits the secretion of gastric acid (inhibition of the enzyme H + / K + -ATPase) on the surface of parietal cells of the stomach. This enzyme system refers to proton, i.e., acid pumps. That is why the drug is classified as an inhibitor of the proton pump of the stomach, blocking the acid in the final stage of production.

The antisecretory effect occurs an hour after administration and reaches a maximum in 2-4 hours. The effectiveness of the active substance relative to oppression of acid secretion increases with the systematic use of the drug. But a stable action is achieved 72 hours after the start of the treatment. After the application is completed within 2-3 days, the secretory activity is restored.

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Pharmacokinetics

Pharmacokinetics Rabbitin - a process of absorption, metabolism, distribution and excretion of the drug. Let's consider each of the processes in more detail:

• Absorption - the active substance is absorbed in the intestine, the maximum concentration in the blood plasma occurs 3-4 hours after taking a dose of 20 mg. When administered orally, bioavailability is 52% and does not increase with repeated use. Eating does not affect absorption.
• Distribution - rabeprazole binds to blood proteins at 96.3%.
• Metabolism - the main metabolites are carboxylic acid and thioether. At low concentrations, secondary metabolites are also present: a mercapturic acid conjugate, a sulfone and dimethylthioether. Minor antisecretory activity has a dimethyl metabolite, but it is not present in the blood plasma.
• Excretion - 90% of the dose is excreted in the urine in the form of metabolites: carboxylic acid and conjugate of mercapturic acid.

If the drug is used by patients with renal insufficiency on supporting hemodialysis, then the distribution process is similar to Rabbitin activity in healthy patients. Half-life takes from 1 to 4 hours. At the same time, the dosage increased by half was taken into account. When using tablets by patients with hepatic insufficiency, the elimination half-life increases by 2-3 times. Half-life takes about 12, 3 hours.
Pharmacokinetic processes in elderly patients, that is, the processes of excretion, distribution and metabolism are doubled. The maximum concentration in the blood plasma increases by 60%, but there are no signs of accumulation.

[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26],

Dosing and administration

The method of administration and dose are selected for each patient individually.

• Peptic ulcer of duodenum and peptic ulcer of the stomach - 20 mg twice a day. The course of treatment for 2 to 4 weeks, with maintenance therapy take 10 mg once a day to 12 months.
• Not ulcerous indigestion - 20-40 mg once a day for 2-3 weeks.
• To kill N. Pouli - 20 mg 2 times a day for 7 days. Eradication therapy is carried out with antibiotics (amoxicillin, clarithromycin, tetracycline), metronidazole, furazolidone and bismuth preparations.
• The syndrome of Zollinger-Ellison is the initial dose of 60 mg per day and, if necessary, increases.
• Chronic gastritis with increased acid-forming function of the stomach (in the stage of exacerbation) - 20-40 mg per day for 2-3 weeks.

Tablets are not chewed and not crushed, the product must be swallowed whole.

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Use Rabifin during pregnancy

Use of Rabifin during pregnancy is prohibited. Contraindications are based on the fact that the possibility of using tablets is not sufficiently studied. Experimentally proved, the drug penetrates the placental barrier and is excreted in breast milk. Proceeding from this, the medication is not recommended during lactation, when it is used, it is necessary to stop breastfeeding.

Given the profile of side effects of the active substance, Rabifin is not recommended for use in controlling mechanisms. Tablets can cause drowsiness and dermatological reactions.

Contraindications

Contraindications Rabifin are based on the effect of the active substance on the patient's body. Tablets are not allowed for use with:

• Individual intolerance to rabeprazole
• Hypersensitivity to substances substituted with benzimidazole or to any other ingredient
• During pregnancy and lactation
• Pediatric patients

With special care, the medication is used for renal and hepatic insufficiency. This is due to the fact that rabeprazole changes its pharmacokinetic properties.

[27], [28], [29]

Side effects Rabifin

Side effects of Rabifin occur when non-compliance with the instructions for its use. The pharmaceutical is well tolerated, and the side effects are of minor or moderate nature. Most often, patients complain of violations from the liver and digestive tract: flatulence, belching, abdominal pain, diarrhea and constipation. In addition, there may be an increase in liver enzymes, dry mouth and taste disorders.

Disturbances are possible on the part of the hemopoietic system and the nervous system: leukopenia, dizziness, drowsiness, headaches, agitation. Adverse actions are manifested in the form of allergic reactions: bronchospasm, skin rash and itching, angioedema. In rare cases, possible pain in the back and chest, urinary tract infection, sinusitis, pharyngitis, visual impairment, increased sweating and weight gain.

[30], [31], [32], [33]

Overdose

Overdose occurs when exceeding the recommended dosage or prolonged use. Most often, patients complain of symptoms such as:

• Headache
• Dry mouth
• Nausea and vomiting
• Drowsiness
• Increased sweating

To eliminate adverse symptoms, maintenance therapy and symptomatic treatment are performed.

[39], [40], [41], [42], [43]

Interactions with other drugs

The interaction of rabbitin with other drugs is possible with appropriate medical indications. Rabeprazole, like similar inhibitors of the proton pump, do not interact with medicaments that are metabolized by enzymes of the system CUR450 (warfarin, phenytoin, theophylline, diazepam). The active substance causes a prolonged decrease in the production of hydrochloric acid, but it can work with means, the absorption of which depends on the pH of the contents of the stomach.

Rabeprazole reduces the concentration of ketoconazole in the blood plasma by 33% and raises the minimum concentration of digoxin by 22%. Therefore, the interaction of these drugs requires a dose adjustment. With simultaneous use with active metabolite clarithromycin, the concentration of the active component increases by 24%. The drug does not interact with liquid antacids and food.

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Storage conditions

Storage conditions Rabbit - tablets should be kept in their original packaging, out of the reach of children and protected from sunlight. Storage temperature should not exceed 25 ° C.

If the storage rules are not observed, the medicine loses its pharmaceutical properties and is prohibited to use. 

[50], [51], [52], [53], [54]

Shelf life

Shelf life is 24 months from the production date indicated on the medicine package. At the end of this period, tablets are prohibited from taking and should be disposed of. 

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