Rabijem 10

Rabidzh 10 - a drug used to treat diseases of the digestive system. Let's consider the instruction to the given preparation and all nuances of its use.

Medication refers to the pharmacological group of agents for the treatment of gastroesophageal reflux disease and ulcers. It is included in the category of proton pump inhibitors, as it is prescribed for the treatment of acid-dependent diseases. The international name is rabeprazole. Manufacturer of Tulip Lab Prive Limited, India. 

Rabid 10 is released by prescription.

Indications Rabijem 10

The main indications for the use of Rabid 10 are the therapeutic effects on the digestive system and metabolism. The medicine is used to treat:

• Duodenal ulcer
• Gastroesophageal reflux disease
• Stomach ulcer
• Zollinger-Ellison syndrome and pathological hypersecretion
• Exacerbation of chronic gastritis (with increased acid-forming function of the stomach)
• Functional dyspepsia
• Eradication of Helicobacter pylori (in combination with antibacterial agents)

If the patient has malignant diseases, then symptomatic improvement is observed with rabeprazole therapy. Proceeding from this, before starting the use of tablets, it is necessary to exclude oncology. 

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Release form

The form of release - tablets of the round form, covered with an enteric shell. Rabid 10 is released at a dosage of 10 and 20 mg. Rabidj 10 mg has a light yellow capsule, and 20 mg is red-brown. One package contains one strip per 10 tablets.

The active substance of rabeprazole, auxiliary: hydroxypropylcellulose, magnesium oxide, diethyl phthalate, sodium croscarmellose, magnesium stearate, manitum and others.

[3], [4]

Pharmacodynamics

Data on the pharmacodynamics of Rabid 10 indicate that the drug is classified as an antisecretory compound, does not have the properties of H2 receptors or cholinergic antagonists, but it suppresses gastric acid. Oppression of acid secretion occurs by inhibiting gastric H + -, K + ATPase on the secretory surface of parietal cells of the stomach.

The enzyme described above refers to proton or acid pumps, therefore rabeprazole is included in the category of gastric inhibitors. The active substance blocks the secretion of gastric acid at the last stage. In stomach cells, rabeprazole is activated at pH = 3D 1,2, the half-life takes about 78 seconds.

[5], [6], [7], [8]

Pharmacokinetics

Pharmacokinetics Rabid 10 allows you to find out information about the processes occurring in the body after taking the medication. Since the tablets are coated with an enteric coating, they are quickly absorbed in the intestine. Bioavailability is 52%. If the drug is taken concomitantly with fatty foods, the absorption slows down for several hours, but the concentration and absorption are unchanged.

About 96.3% of the active component binds to blood plasma proteins. Metabolised in the liver. It is excreted mainly by kidneys in the form of metabolites - thioether and sulfone, which do not possess antisecretory properties. About 10% of the drug is excreted with feces.

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Dosing and administration

The method of administration and dose depend on the indications for use. In the treatment of duodenal ulcers (in the absence of H. Pylori) take 20 mg 1-2 times a day for a month. If stomach ulcer is 20 mg 1-2 times a day for 1-2 months. For treatment of gastroesophageal reflux disease, patients are prescribed 20 mg of rabeprazole 1-2 times a day for 4-8 weeks. As a maintenance therapy for this disease, the pill is taken for 12 months, the dosage is selected individually.

To eradicate Helicobacter pylori, combined therapy is used in combination with antibacterial agents (amoxicillin, clarithromycin, tetracycline, furazolidone, metronidazole, bismuth preparations). The Zollinger-Ellison syndrome is treated at an initial dosage of 60 mg, gradually increasing to 120 mg per day. For the treatment of functional dyspepsia and chronic gastritis take 20 mg 1-2 times a day for 2-3 weeks.

If the drug is prescribed to elderly patients or people with kidney disease or impaired hepatic function, the doctor adjusts the dosage, since side effects are possible. As a rule, the treatment of this category of patients is under the supervision of a doctor. Tablets are not recommended to chew, grind or break. Rabid should be swallowed whole, washed down with water.

[21], [22], [23],

Use Rabijem 10 during pregnancy

Pregnancy and breastfeeding are a ban on the use of a medication. 

Contraindications

Contraindications to the use of Rabid 10 are based on individual sensitivity to the active ingredient and other components of the drug. The drug is not prescribed for patients with intolerance to rabeprazole or substituted benzimidazole.

Tablets are not used to treat lesions of the gastrointestinal tract in pediatric patients, since there is no information on the safety of such therapy.

[11], [12], [13], [14],

Side effects Rabijem 10

Side effects of Rabid 10 are possible in case of incorrectly selected dosage or duration of treatment. In general, from the side of the body there are such reactions: asthenia, malaise in the abdomen and chest, swelling, swelling of the face, sensitivity to light, fever, allergic pruritus and rash.

Tablets can cause nausea and vomiting, migraine, arterial hypertension, constipation, dry mouth and flatulence. Violations are possible in all body systems. So, from the endocrine system most often there is hyperthyroidism and hypothyroidism. Possible disruption of nutrition and metabolism, muscle twitching and cramping, anxiety, insomnia, shortness of breath, allergic reactions. To eliminate the above symptoms, you must stop taking the pill and seek medical help.

[15], [16], [17], [18], [19], [20]

Overdose

Symptoms of overdose occur very rarely. If this happens, then patients complain of headaches and dizziness, nausea and vomiting, flatulence, constipation, diarrhea, allergic reactions to the skin.

To resolve the above reactions, symptomatic therapy and maintenance treatment are performed. There is no specific antidote. 

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Interactions with other drugs

The interaction of Rabid 10 with other drugs is possible only with the permission of the doctor. Since Rabichem 10 causes a significant depression of the secretion of gastric juice, it can change the effectiveness of medicines whose absorption is dependent on the pH of the gastric juice. For example, when used with digoxin and ketoconazole, their bioavailability and plasma concentration are reduced. Therefore, the doses of all drugs should be selected by a doctor.

If rabeprazole is taken concomitantly with antacid agents, then this does not entail significant disturbances in the concentration of both drugs in the blood plasma.

[27], [28],

Storage conditions

The storage conditions of Rabid 10 imply strict compliance with the temperature regime from 15 to 25 ºC. Tablets should be stored in their original packaging, in a dry place, protected from direct sunlight and out of reach of children.

Failure to observe the storage rules leads to damage to the drug. Tablets can change their physicochemical properties, that is, color and smell. If this happens, then the medicine is forbidden to take and must be disposed of.

[29], [30], [31], [32], [33], [34],

Shelf life

Shelf life is 24 months. At the expiration of this date, the medicine is not allowed, since uncontrolled side effects are possible. Overdue pills are dangerous and do not bear therapeutic value.

[35], [36], [37],