Rabelok

Rabelok is a drug with antiulcer properties. Consider the indications for its use, dosage, possible side effects and other medicinal properties.

The international name is Rabeprazole, manufactured in India by the company Kadila Pharmaceuticals Ltd. Pharmacotherapeutic group of medicament - proton pump inhibitors. The drug affects the digestive system and is used to treat acid-dependent diseases.

The antiulcer is an inhibitor of H ⁺ -K ⁺ -ATPase. The mechanism of action is based on the inhibition of enzymes in parietal gastric cells. This blocks the final stage of the formation of hydrochloric acid. The effect is dose-dependent and leads to oppression of hydrochloric acid secretion (stimulated and basal).

Rabelok - an effective antiulcer, released only on medical prescription. Before taking the drug, medical consultation and examination of the digestive organs are required.

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Indications Rabelok

Rabelok is the treatment and prevention (in the phase of exacerbation) of peptic ulcer of the duodenum and stomach. The drug is effective in gastroesophageal reflux and diseases of the gastrointestinal tract associated with Helicobacter pylori (in combination with antibiotic drugs).

Before its use it is necessary to undergo a medical examination and exclude possible oncological lesions of the stomach and digestive organs. This is due to the fact that the use of the drug can mask pathological symptoms, which will significantly delay the proper diagnosis and complicate further treatment. If the tablets are taken by patients with impaired liver function or kidney function, the dosage is not adjusted. But with serious violations, the medicine is taken only under medical supervision.

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Release form

Form of release of the drug - tablets, covered with enteric coating. Tablets produce 10 and 20 mg of the active ingredient. In each pack of 1 blister for 10 capsules.

In addition to the tablets, there is Rabelok lyophilizate for a solution for infusions of 20 mg in vial No. 1. This form is prescribed for patients who can not take the drug orally.

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Pharmacodynamics

Pharmacodynamics Rabelok is information about the mechanism of action of the active components of the drug. The active substance refers to inhibitors of the proton pump and suppresses the activity of the enzyme H + K + - ATPase. This occurs in parietal gastric cells and stops the formation of hydrochloric acid in the last stage. This effect is dose-dependent, since irrespective of the stimulus, depression of the secretion of hydrochloric acid results.

With the covalent bond, rabeprazole binds to the proton pump in parietal cells, causing an irreversible decrease in the secretion of hydrochloric acid. That is, the kinetics of the active component in the blood plasma does not affect the antisecretory action, but increases the biological activity and half-life (20-24 hours). 

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Pharmacokinetics

Pharmacokinetics Rabelok are processes that occur with the components of the drug after administration. The active substance is rapidly absorbed from the gastrointestinal tract. If a dose of 20 mg is taken, the maximum concentration is reached after 3-4 hours, the changes in concentration depend on the dosage and are linear in nature. Bioavailability is 52% and does not increase with multiple admission. The time of intake and consumption of food does not affect the absorption process.

Binding to plasma proteins - 97%, is metabolized in the liver. About 90% is excreted in the urine in the form of metabolites (carboxylic acid, mercaptopuric acid conjugate), the remaining 10% are excreted with feces. If Rabelok is taken by elderly patients, the removal of rabeprazole is slowed.

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Dosing and administration

The way of application and dose are selected by the doctor, individually for each patient. A single dose is 10-20 mg of rabeprazole. Duration and frequency of application depend on the treatment regimen and indications for use.

• In case of peptic ulcer of stomach and peptic ulcer, 20 mg 1-2 times a day for 2-8 weeks are prescribed.
• For non-ulcerative dyspepsia, 40 mg once a day or 20 mg twice a day for 2-4 weeks.
• To treat the syndrome Zollinger-Ellison appoint 20-60 mg per day. If necessary, the dosage can be increased to 120 mg per day, the duration of therapy is 2-8 weeks.
• Chronic gastritis in the acute stage is treated, taking 40 mg per day, the course of treatment 2-4 weeks.
• If the pills are used to eradicate H. Pulogi, the optimal treatment regimen is the attending physician. As a rule, patients are prescribed 20 mg twice a day in combination with other antibiotics.

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Use Rabelok during pregnancy

Use of Rabelock during pregnancy is contraindicated. According to experimental studies, rabeprazole penetrates the placental barrier in small amounts. But this does not cause violations of fertility and defects in the development of the fetus. The substance is excreted in breast milk, so when it is used, it is necessary to stop the lactation process.

The drug is not prescribed to children of childhood, as today there is no experience of its use in this group of patients.

Contraindications

Contraindications to the use of Rabelok are based on the mechanism of action of its active components in relation to all organs and systems of the patient's body. Tablets and infusions do not apply in such cases:

• Pregnancy and lactemia
• Individual intolerance to medication components
• Hypersensitivity to substituted benzimidazoles
• Oncological diseases of the digestive and gastrointestinal tract.

Side effects Rabelok

Side effects of RAPELOCKS are possible if the recommended dosage is not observed or if the treatment period is exceeded. Rabelok well tolerated, side effects are mild or moderate, but reversible. Most often, patients complain of headaches, nausea and diarrhea. Consider the side effects of all organs and body systems:

• Digestive system - abdominal pain, vomiting, bloating, nausea, eructation. In rare cases, constipation, dry mouth, gastritis, stomatitis and increased activity of liver transaminases occur.
• Central and peripheral nervous system - headaches and dizziness, insomnia, nervousness, drowsiness. In rare cases, there may be visual and taste disturbances, depression.

• Respiratory system - cough, rhinitis, pharyngitis.

In addition to the above symptoms, allergic reactions (skin rash and itching), back and chest pain, calf muscle cramps, chills, fever, urinary tract infections and increased sweating are possible.

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Overdose

Overdose occurs when the recommendation for use and dosage is not respected.

Symptoms:

• Increased sweating
• Dizziness
• Headache
• Drowsiness
• Dry mouth
• Nausea
• Vomiting

To resolve the above symptoms, supportive symptomatic treatment is performed. If the overdose is severe, then it is worth stopping taking Rabelok and seeking medical help to adjust the dose or choose a safer analog drug.

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Interactions with other drugs

Interaction Rabelok with other drugs is possible with an integrated approach to treatment. Consider the most frequent reactions of rabeprazole when interacting with various drugs:

• When used with digoxin, there is an increased concentration in the blood plasma, so dose adjustment is required.
• Ketoconazole reduces the bioavailability of rabeprazole.
• With simultaneous use with antacids, no interactions are observed.
• With the use of atazanavir, rhytone belief, omeprazole or lansoprazole, a decrease in atazanavir exposure is observed, but absorption remains normal. 

The active substance provides a prolonged and pronounced inhibition of gastric acid secretion. The drug normally interacts with drugs, the absorption which directly depends on the pH of the contents of the stomach.

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Storage conditions

The storage conditions of the Rabelock correspond to the storage rules of other tableted medicines. Rabelock should be kept in a dry place inaccessible to children and protected from sunlight. The temperature should be within 25 ° C.

If you use Rabelok in the form of a solution for infusion, the finished solution can be stored for no more than 4 hours at room temperature and no more than 24 hours if stored in a refrigerator. If the color or odor changes, the medicine should be disposed of and prohibited from taking.

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Shelf life

The shelf life is 24 months from the production date, which is indicated on one side of the medicine package. At the expiration of the drug is forbidden to take, because uncontrollable side effects are possible.