Rabeprazole-health

Rabeprazole-health is a pharmaceutical used to treat diseases of the stomach and digestive organs. Consider the main indications for its use, dosage and other nuances of use.

Rabeprazole-health refers to a pharmacotherapeutic group of drugs for the treatment of diseases associated with acidity disorders. The chemical and international name of the drug is Rabeprazolum, the manufacturer is the pharmaceutical company "Zdorovie", Ukraine.

[1], [2], [3], [4], [5], [6]

Indications Rabeprazole-health

Rabeprazole-health is based on the mechanism of action of its components. The drug is effective in treatment and prevention:

• Peptic ulcer of the duodenum (in the stage of exacerbation)
• Zollinger-Ellison Syndrome
• Gastric ulcer (benign)
• Gastroesophageal reflux disease (erosive, ulcerative)
• Symptomatic therapy of GERD from moderate to very severe
• Eradication of Helicobacter pylori in combination with active antibacterial drugs.

Before starting the treatment, the patient must undergo a checkup to exclude the possibility of malignant lesions of the stomach. With special care, the drug is prescribed for patients with severe impairment of kidney and liver function. If the tablets cause drowsiness, then to complete a full course of treatment, it is necessary to abandon the activity that requires an increased concentration of attention.

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Release form

The form of release - tablets №10 with a dosage of 10 and 20 mg. The tablets are biconvex, covered with an enteric-soluble coat of brown-red color (10 mg) or brown-yellow (20 mg).

One tablet contains the active ingredient - rabeprazole sodium and auxiliary substances (mannitol, magnesium stearate, titanium dioxide, mannitol and others).

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Pharmacodynamics

Pharmacodynamics Rabeprazole-health indicates its antisecretory properties. The agent relates to antiulcer inhibitors of a proton pump. The active substance gradually accumulates in the acidic environment of the cells of the mucous membrane of the stomach and passes into the active form - sulfenamide. The active metabolite inhibits H +, K + - ATPase, blocks the secretion of hydrochloric acid due to the cessation of the release of hydrogen ions into the gastric cavity.

Has bactericidal properties against Helicobacter pylori and accelerates anti-Helicobacter pylori activity of other antibiotics. A dose of 20 mg leads to suppression of gastric secretion within 60 minutes and reaches its maximum after 3-4 hours. The inhibition of basal and stimulated secretion persists for 48 hours. A stable antisecretory effect occurs 72 hours after the onset of admission. After the end of treatment parietal cells are restored in 2-3 days. 

[12], [13], [14], [15]

Pharmacokinetics

Pharmacokinetics Rabeprazole-health is an algorithm for the action of active components after ingestion. Tablets are completely and quickly absorbed from the digestive tract. Bioavailability leaves 52% (if passed through the liver) and does not increase with repeated use.

Food intake and time of day do not affect absorption. Binding to blood proteins at 97%. The drug is metabolized in the liver with the active participation of enzymes of the cytochrome P450 system. 90% of the active components are excreted in the urine in the form of metabolites, and the remaining 10% with feces.

[16], [17], [18], [19], [20], [21], [22]

Dosing and administration

The way of application and dose depends on the indications for the use of the medication, so they must be selected by the doctor, for each patient separately. With exacerbation of peptic ulcer of the stomach and duodenum take 20 mg 1-2 times a day. The course of treatment takes from 4 weeks, if there are no scarring, then 8 weeks if the ulcer is localized in the duodenum - 6-12 weeks.

To treat gastroesophageal reflux appoint 20 mg 1-2 times a day for 4-8 weeks. Supporting dosage of 10-20 mg / day of the drug is considered. With Helicobacter pylori infection, the drug is used as part of a triple eradication regimen. Rabeprazole 20 mg is used concurrently with amoxicillin 1000 mg and clarithromycin 500 mg, the duration of treatment is 7-10 days.

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Use Rabeprazole-health during pregnancy

Use Rabeprazole-Health during pregnancy is not recommended. To date, there is no reliable data on its safety for the human body. Research on reproductive functions was performed on animals, but did not provide evidence of impaired fertility or other side effects to the fetus. But the prolonged use of rabeprazole provoked insignificant placental penetration in rats.

Rabeprazole-health penetrates into breast milk, therefore it is forbidden to use it during lactation. Medication is not prescribed to under-age patients, as there is insufficient information about such therapy.

Contraindications

Rabeprazole-health depends on the reaction of the body to the components of the drug. Tablets are not recommended for use with:

• Individual intolerance to rabeprazole and other pill components
• Pregnancy
• Breast-feeding
• Child age of the patient

If these recommendations are not followed, serious side effects that require medical attention are possible.

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Side effects Rabeprazole-health

Side effects of rabeprazole-health occur when the duration of therapy or dosage is exceeded. As a rule, patients complain of abdominal pain, nausea and vomiting, constipation, flatulence. In addition, it is possible to increase the activity of hepatic transaminases, severe headaches, back and chest pain, dry mouth.

In rare cases, there is an increase in body weight, stomatitis, excessive sweating, coughing, bronchitis, puffiness, visual impairment and taste. To eliminate side effects, it is recommended that you stop taking rabeprazole-health and consult your doctor to adjust the dose.

Overdose

Overdosing occurs when the recommended course of treatment is exceeded and high doses of the drug are administered. Side effects cause headaches and dizziness, nausea, vomiting, abdominal pain, constipation.

Symptomatic maintenance therapy is used for treatment. Dialysis is not used, because it is ineffective. In any case, if symptoms of an overdose occur, you should consult your doctor to adjust the dose of the drug.

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Interactions with other drugs

Interaction Rabeprazole-health with other drugs is used in medical treatment and in the complex treatment of certain diseases. If the drug is used with ketoconazole, this leads to a decrease in its concentration in the blood plasma and an increase in the level of digoxin. The drug has no clinically significant interactions with drugs that are metabolized in CYP (diazepam, phenytoin, theophylline).

The active substance causes a long decrease in the production of hydrochloric acid, therefore it normally functions with medicines, the absorption of which depends on the pH of the contents of the stomach. If the drug is used concurrently with ketoconazole or itraconazole, then this leads to a decrease in their concentration in the blood plasma. Therefore, when using these drugs, you need to see a doctor and adjust the dosage. Rabeprazole does not interact with antacids, such as magnesium or aluminum hydroxide. Foods that are low in fat do not affect absorption. But when applying the medicine with fatty food, the absorption is delayed for 4 or more hours, the maximum concentration is unchanged.

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Storage conditions

Storage conditions Rabeprazole-Health - tablets should be stored in a dry place, protected from sunlight and out of reach of children. Storage temperature should not exceed 25 ° C.

If the above recommendations are not observed, the medicament may change its physicochemical properties, that is, color, odor, consistency. If this happens, the tablets are forbidden to use and must be disposed of.

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Special instructions

Rabeprazole can cause drowsiness, so when using it, avoid working with dangerous mechanisms or driving vehicles. Observance of all recommendations specified in the instruction is a guarantee of maximum therapeutic effect.

Shelf life

Shelf life - 24 months from the date of production. Overdue rabeprazole-health is forbidden to use for medicinal purposes. Tablets are released only on the prescription.

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