Ophthalmic

Oftamirin refers to a group of drugs that act on the senses; ATS code S03D; international name - Myramistin; a synonym for Okomistin.

[1], [2],

Indications Ophthalmic

As an antiseptic, Ophthalin is used for ophthalmic diseases that develop due to bacterial, viral or fungal infections: conjunctivitis and blepharoconjunctivitis in acute and chronic form, keratitis (inflammation of the cornea), keratouveitis (inflammation of the cornea and vascular membrane of the eyeball), as well as eye injuries ( mechanical, thermal, chemical).

With surgical interventions in ophthalmology, Ophthalmic can be used to prevent infection.

[3], [4]

Release form

Form release: eye drops: 5 ml per bottle.

[5], [6], [7], [8]

Pharmacodynamics

Antiseptic effect Oftamirin provides the constituent compound of quaternary ammonium bases - miramistin. It is a cationic detergent (surfactant) with a strong antiseptic effect.

Due to the presence in the molecules of myramistin strongly basic groups, the drug acts on bacteria as a toxin: it oxidizes proteins and thereby destroys the integrity of cytoplasmic membranes of microbial cells. As a result, this leads to a violation of the osmotic balance of the microbial cell and its death.

Okomistin has a bactericidal effect against all gram-negative and gram-positive, anaerobic and aerobic, asporogenous and spore-forming bacteria and bacteroids, as well as the Herpes simplex virus.

Antifungal effect of the drug on the fungi of the genus Candida, Aspergillus, Penicillium, Rhodotorula rubra, Torulopsis gabrata, Malassezia furfur), as well as dermatophytes of the genus Trichophyton and Microsporum.

[9], [10], [11], [12], [13], [14], [15],

Pharmacokinetics

Ophthalmic is applied topically - in the form of instillation, and its active substance is not absorbed by the mucous membranes, or skin, and therefore does not enter the blood.

[16], [17], [18], [19], [20], [21], [22], [23], [24], [25]

Dosing and administration

Drop Ophthalin should be instilled in the eye - directly into the conjunctival sac (the space between the eyeball and eyelid), without touching the eye, eyelashes and eyelids with the tip of the dropper. If the patient has contact lenses before digging in, they should be removed and put on after 15-20 minutes after the procedure.

The standard dose for infectious and inflammatory eye diseases is 1-2 drops per eye at least four times a day. The duration of treatment is determined by an ophthalmologist.

In case of a thermal or chemical burn, before use, Opharymine should be rinsed and then instilled 1-2 drops into each eye for 60 minutes to 120 minutes every 10 minutes.

[32], [33], [34],

Use Ophthalmic during pregnancy

Use during pregnancy and lactation is possible, but it should only be prescribed by the attending physician - in case of emergency.

Contraindications

These agents are contraindicated to use in the presence of individual intolerance to miramistin; Drops are not assigned to children.

[26], [27], [28]

Side effects Ophthalmic

With a general good tolerance of Ophthalin, in some patients, local irritation in the form of itching and redness of the eyes can occur immediately after the application of drops.

[29], [30], [31]

Overdose

Overdose with topical use of Opharymine is not fixed.

[35], [36], [37], [38], [39], [40], [41]

Interactions with other drugs

Ophthalmic can be used in combination with other antimicrobial agents of topical application while observing a 15-minute break between their instillations.

[42], [43], [44], [45]

Storage conditions

Storage conditions Oftamin: at temperatures up to + 30 ° C, freezing is unacceptable.

[46], [47], [48],

Shelf life

Shelf life of the unopened vial is 3 years, from the moment of opening the vial the shelf life of the drug is 25 days.

[49], [50], [51]