Ovosept

Ovosept belongs to the pharmacological group of combined hormonal contraceptives. Other trade names for the drug are Ovidon, Anthevin, Microinon 30, Miniziston, Oralcon, Rigevidone, Trigestrel, Trikwilar, Levora.

Indications Ovosept

Indications for the use of Ovosept, in addition to preventing unwanted pregnancies, are functional disorders of the menstrual cycle (including dysmenorrhea), premenstrual syndrome, dysfunctional metrorrhagia (uterine bleeding).

[1], [2], [3],

Release form

Form release: white and yellow dragees, in one package 21 dragees.

[4]

Pharmacodynamics

The contraceptive effect of Ovocet is provided by the synthetic analogues of sex hormones entering into it: levonorgestrel - a derivative of 19-nortestosterone and ethinyl estradiol - synthetic follicular estradiol. The mechanism of their action is due to the fact that levonorgestrel blocks the gonadotropic function of the pituitary gland and thereby stops the production of foliotropin (follicle stimulating hormone), as well as luteotropin (luteinizing hormone). This leads to suppression of ovulation (maturation of the egg and its release from the ovaries), and also prevents the process of reducing the viscosity of cervical mucus (mucus of the cervix), which usually accompanies ovulation. Levonorgestrel also inhibits the proliferation of the endometrium.

Under the influence of ethinyl estradiol, the production of liver-binding estrogen and testosterone protein SHBG and transcortin, a protein that binds corticosterone and progesterone in the blood plasma, is increased. In addition, ethinyl estradiol elicits active division of endometrial cells.

The combination of agonistic and antagonistic actions of active components of Ovosept, according to the producers, makes fertilization of the egg impossible and prevents pregnancy.

[5], [6], [7], [8], [9], [10], [11]

Pharmacokinetics

After ingestion, the active substances of Ovosept are adsorbed into the digestive tract (in the small intestine), the total bioavailability is close to 100%. Ethinyl estradiol binds to plasma proteins by 94%, levonorgestrel - by 55.5%. The highest concentration in the blood is observed 60-90 minutes after taking Ovosept. The distribution of levonorgestrel and ethinyl estradiol on tissues occurs fairly evenly, but for ethinyl estradiol, it is characteristic to increase the content of beta-lipoproteins in the blood and accumulate in adipose tissue cells.

Ethinylestradiol is transformed in the liver and intestines by oxidation with the formation of two metabolites (2-OH-ethynyl-estradiol and 2-methoxyethynylestradiol) and compounds of glucuronic and sulfuric acids; approximately 60% of which is excreted with bile through the large intestine, the rest - kidneys with urine. Levonorgestrel is metabolized in the liver, 45% of inactive metabolites are eliminated in the urine, 32% - with intestinal excrement. The average duration of the half-life of the drug from the body is ± 24 hours.

[12], [13], [14], [15]

Dosing and administration

According to the official instructions to the drug, when prescribing it should pay attention that the pellets of different colors contain different amounts of active substances; to observe the correct reception of the pills on the package, the number of dragee, day of the week and arrow is indicated, which shows the direction of reception of the next dragee. You should take 1 tablet every day.

Dragee should be taken whole inside, not liquid, squeezed a little water. Time of reception of value has no (for example, after a breakfast or a supper), however following receptions of dragees should be at the same time, that is in 24 hours.

For the purpose of contraception, Ovidon is used, starting from the first day of menstruation for 21 days, then a 7-day break occurs, during which bleeding similar to the menstrual period occurs. On the 8th day, it is necessary to start taking the tablets from the next package (even with continued bleeding).

If you missed taking one pills in the first two weeks of the cycle, you should take 2 pills the next day and then continue with regular intake. If you miss two tablets in a row, you need to take 2 pills in the next 2 days, then continue to receive Ovosept on a regular basis, and use additional contraceptive methods before the end of the cycle.

For therapeutic purposes, dosage is given individually. 

[21], [22], [23], [24], [25], [26]

Use Ovosept during pregnancy

Use during pregnancy, as well as during breastfeeding is contraindicated.

Contraindications

Contra-indications of this contraceptive include:

• sensitivity to the components of the drug;
• chronic liver diseases (including hyperbilirubinemia and tumor formations);
• cholelithiasis;
• cholecystitis;
• chronic colitis;
• presence or indication in anamnesis of severe cardiovascular and cerebrovascular, thromboembolism or predisposition to them;
• Malignant tumors (primarily breast cancer and endometrium);
• lipid metabolism disorders;
• arterial hypertension;
• diabetes mellitus with vascular complications;
• sickle cell anemia, chronic hemolytic anemia;
• vaginal bleeding of unknown etiology;
• migraine;
• otosclerosis;
• herpes;
• urogenital infections.

[16], [17], [18]

Side effects Ovosept

Application Ovosept can cause such side effects as breast engorgement; changes in appetite; allergic reactions (rash, itching, dyspnea, swelling of the face, lips or tongue); severe or recurring headaches and dizziness until fainting; numbness of limbs; weakness; loss of hair (alpecia); nausea and vomiting; increased nervousness and mood changes; decreased hearing acuity; bloody vaginal discharge or breakthrough bleeding; yellowing of the skin or sclera; increase in body weight.

It is important to keep in mind that women who use hormonal contraceptives for a long time increase the risk of oncological diseases of the breast and cervix.

[19], [20]

Overdose

Ovosept causes headache and nausea; treatment of the consequences is symptomatic.

[27], [28]

Interactions with other drugs

With caution apply Ovosept in combination with inducers of hepatic metabolism (rifampicin), phenobarbital derivatives, anticonvulsants (phenytoin and carbamazepine), with broad-spectrum antibiotics (tetracyclines, ampicillin, chloramphenicol, neomycin, etc.) - because of a possible reduction in contraception.

Admission Ovosept simultaneously with coumarin anticoagulants may require correction of their dosage.

Ovosept increases the bioavailability of tricyclic antidepressants and beta-blockers. The drug should not be taken concurrently with drugs that have side effects on the liver.

[29]

Storage conditions

Storage conditions: in a dry place inaccessible to children, at a temperature of + 15-28 ° C.

[30]

Shelf life

Shelf life - 5 years.

[31], [32]