D-Vooid

D-Vooid is a medication prescribed for adults and children alike. The second name that carries the medicine is Desmopressin. Let's consider, to whom and when it is necessary to take D-Vooid, the features of prescribing, precautions and interaction with other medicines.

D-Vooid or Desmopressin is a synthetic medication that acts as an analogue of vasopressin. The drug has a high antidiuretic effect. Vessels and their smooth muscles, as well as internal organs, have a direct effect.

D-Vooid is a drug that helps cure many diseases, both in adults and in small patients. Remember that appoint a drug should a doctor, do not self-medicate.

Indications of the d-Void

Indications for use are monitored by the attending physician. Before giving evidence for use, the doctor should fully examine and accurately diagnose the disease.

Assign to:

• Treatment of diabetes insipidus in children and adults.
• To conduct testing for the concentration characteristics of the kidneys.
• Treatment of nocturnal enuresis (incontinence) in children who are older than six years.
• Treatment of polyuria and polydipsia in the postoperative period.
• Treatment of edema of the nasal mucosa, as well as pronounced renite.

With intravenous administration, D-Vooid is prescribed for:

• Treatment of von Willebrand disease.
• Treatment of hemophilia A of the first forms of severity.

To avoid overloading the body with D-Vodid medication, special control is required for such groups of patients as: elderly people, adolescents and young children, as well as patients who have a risk of increased intracranial pressure, renal dysfunction, electrolyte and water balance disorders , fibrosis of the bladder and cardiovascular disease.

If D-Vooid is used as a diagnostic tool and for introducing a repeated dosage, there is no need to perform forced hydration. The patient must maintain the body's water balance independently. If the drug is taken by children under the age of one year to study the concentration ability of the kidneys, then the medication should be taken only under the condition of the doctor's control and on inpatient treatment.

Release form

• Nasal Dosed Spray
• Nasal drops
• Tablets of 0.1 mg and 0.2 mg

Tablets are white round capsules with a risk on one side and the first letter of the name of the drug on the other. One tablet contains desmopressin acetate - 100 μg, and as auxiliary substances: povidone K30-2 mg, lactose monohydrate 120 mg, magnesium stearate -1 mg and potato starch 76.9 mg. Tablets are available in packages of 20, 30 and 90 pieces in polyethylene containers and cardboard packages.

[1]

Pharmacodynamics

Pharmacodynamics drugs as a structural analogue of the natural hormone in the human body - arginine-vasopressin. D-Vooid is the result of changes in the construction of vasopressin molecules, that is, deamination of 1 cysteine and its replacement with 8-L arginine and 8-D arginine.

The therapeutic effect is achieved due to a significant increase in the permeability of the epithelium and increased reabsorption. D-Vooid helps to reduce the amount of urine released by the body and increases its osmolarity, while reducing osmolality in the blood plasma. The result of pharmacodynamics D-Vooid is a decrease in the frequency of urination, normalization of nocturnal diuresis. Please note that therapeutic actions begin to appear during the first hour and last from 8 to 12 hours.

[2], [3]

Pharmacokinetics

Pharmacokenetics allows you to learn about all the stages of chemical transformation of the drug in the human body. Thus, intranasal application of D-Vooid is about 10%. While the absorption of D-Vooid in intranasal application is not complete, but fast.

There is also a significant concentration of the drug in the blood plasma. Typically, the increase occurs 30 minutes after application and reaches its maximum after one hour and is completely dependent on the administered dose of the drug.

The volume of distribution of D-Vooid is up to 0.3 liters per kilogram. D-Vooid does not penetrate the blood-brain barrier. After intranasal administration, the half-life of the drug is up to 5 hours, but with a small amount of D-Vooid drug, it is metabolized in the liver.

[4], [5], [6], [7]

Dosing and administration

The way of application and the dose of the medicine depend on the purpose for which the medicine is taken. Let's look at the main diseases, which D-Vooid helps to combat and the methods of application, and the dosage of the drug.

• Non-diabetes mellitus - adults 10-20 mcg 2 times a day, in individual cases the dose is selected individually. Children - 20 mcg 2 times a day, but if during the drug the above symptoms of overdose are noticed, then the drug should be stopped.
• Primary nocturnal enuresis - up to 40 mcg, but the exact dose is selected individually by a doctor. In this case, the course of treatment should be at least three months.
• Testing for the concentration of kidneys - for adults 40 mcg, for infants 10 mcg, for children over one year 20 mcg.
   

[14], [15], [16], [17], [18]

Use of the d-Void during pregnancy

Use during pregnancy is not thoroughly studied. Still no studies have been conducted that would prove the safety of the drug during pregnancy or lactation. Before using D-Vooid during pregnancy, one must soberly weigh the pros and cons and really assess the possible risk of the drug for the baby's future and the body of the pregnant woman.

The use of D-Vooid during pregnancy requires extreme caution. So, according to studies, a small amount of medicine that enters the body of an infant with breast milk is much less than the volume that can affect diuresis.

Contraindications

Contraindications for use are based on individual intolerance of the constituents of the medicine. And also with:

• Congenital or psychogenic polydipsia
• Delayed fluid of any etiology
• Anurée and hypoosmolality of plasma
• Hypersensitivity to the drug and heart failure.

Contraindications to the use of D-Vooid exist and with renal failure, violations of electrolyte and water balance of the body, the possible risk of increased intracranial pressure, fibrosis of the bladder. And also during pregnancy and when prescribed for children, at the age of up to one year. Also, with extreme caution, D-Vooid should be taken to patients with bronchial asthma, cardiovascular disease, migraine and epilepsy.

D-Vooid is contraindicated for use by patients who are at risk. But if the drug is still prescribed, then complete control of the period of treatment and use of the drug is necessary. The risk group includes: elderly patients who are over 65 years of age, since there is a risk of side effects. When using D-Vooid, it is necessary to determine the concentration of sodium in the blood plasma, every three days after the start of the drug, and also to observe the process of treatment.

[8], [9], [10], [11]

Side effects of the d-Void

Side effects of D-Vooid, may be caused by individual intolerance to the components of the drug. Side effects:

• Dizziness, coma, headache, impaired consciousness.
• Vomiting, intestinal colic, nausea.
• Arterial hypotension.
• Edema of the nasal mucosa and rhinitis.
• Oliguria.
• Hyponatremia, increase in body weight, water retention in the body, hypoomolality.
• Conjunctivitis, tearing disorders.
• Algodismenorea.
• Allergic reactions, skin dermatitis, rash, itching.

[12], [13]

Overdose

Overdose can cause fluid retention in the body, cause neurological and mental symptoms, contribute to the development of seizures, as well as hyponatremia and hypoosmolarity.

The first thing to do when overdosing is stop taking the medicine. It is also recommended to limit the intake of fluids, in particularly severe cases, a slow infusion of furosemide and concentrated saline solutions.

[19], [20]

Interactions with other drugs

The interaction of D-Vooid with other drugs can cause an allergic reaction, complex irreversible symptoms and reverse the entire treatment. Let's look at how D-Vooid interacts with other drugs.

• When used with selective inhibitors and tricyclic antidepressants, there may be a syndrome of inadequate secretion of homonids, especially antidiuretic syndrome. And also there is a risk of fluid retention in the body and hyponatremia.
• When used with anti-inflammatory drugs, there is a high risk of various side effects.

• When used with loperamide or desmopressins, a triple increase in plasma in the plasma may occur. That in turn will cause a delay of fluid in the body and ginonatriemii. The interactions of D-Vooid with drugs that slow down peristalsis can cause similar side effects.

[21], [22], [23], [24], [25], [26]

Storage conditions

Storage conditions D-Vooid must fully comply with the requirements of the manufacturer. The medicine should be kept in a place protected from children, at a temperature of 15-25 ° C.

Also, the drug should be protected from direct sunlight and from freezing. The bottle with the drug should be in an upright position.

[27], [28]

Shelf life

The shelf life of the D-Vooid is set by the manufacturer and is 24 months. Packaging of the drug is 50 doses of 5 ml, in a bottle with a dispenser. Each bottle is in a cardboard box.

As soon as the medicine began to change its color or consistency, it must be disposed of. Since this is a sign that D-Vooid has lost its medicinal properties due to expired shelf life or improper storage conditions.

[29], [30]