D-Panthenol

D-Panthenol is a multifunctional drug. The medicine is used for injuries and damages to the skin, with scratches and painful calluses, with burns, intertrigo, for moisturizing and healing. D-Panthenol is available in the form of an ointment and cream. D-Panthenol is a panacea for minor skin problems and much more. Let's find out more information about D-Panthenol, its use, side effects and interactions with other drugs. Regardless of the form of release, the medicine is used for skin problems. Let's take a closer look at what D-Panthenol will help with.

• Skin dermatitis, both in adults and in infants.
• Fissures of the nipples - mostly with this problem facing pregnant women and women who are actively involved in sports, especially swimming (due to chlorinated water).
• Disorders of the mucous membrane of the cervix - the drug allows you to restore the integrity of the cervix and remove the pain that worries a woman.
• Scratches and abrasions - D-Panthenol has an anti-inflammatory effect, a great antiseptic preparation that prevents the possibility of suppuration of any wound.
• Burns of any degree - D-Panthenol stimulates cell growth and promotes the fastest recovery of the skin.
• Fissures of the anal passage.
• Helps treat the negative effects of exposure to unprotected skin of wind, cold and high humidity.

In addition, the substance is used and for preventive purposes. So, if the street is cold or very windy, it is recommended to treat sensitive areas of the skin that will fall under the influence of bad weather.

[1], [2], [3]

Indications of the d-Panthenol

The main indications for use are:

• Skin Problems
• Violation of the integrity of the skin
• Burns, including sunburn
• Dermatitis, abrasions, scratches
• Trophic ulcers, furuncles, abscesses
• Bedsores, postoperative wounds
• Cervical erosion
• Poorly engrafted skin grafts
• Cracks and inflammation of the nipples of the breast during lactation, pregnancy
• Infantile infarcts
• Diaper dermatitis
• Irritation from sunlight in children
• Inflammatory processes
• Prevention and treatment of adverse effects of the external environment on the skin (wind, cold, high humidity).

[4], [5]

Release form

The form of release has two kinds, it is a cream and ointment.

Ointment - 5%, is produced in an aluminum tube with a sealed hole, a dosage of 25 and 50 grams.

The main properties of the ointment:

• It is used for the treatment of skin after surgical interventions and with aseptic surgical wounds.
• Helps in the transplantation of skin and skin grafts, as well as with bedsores.
• He treats trophic ulcers, irritations from ultraviolet and x-ray radiation.
• Helps with any inflammation of the skin and boils.
• It is irreplaceable when caring for small children, as it is an excellent prevention of diaper dermatitis and diaper rash.
• It is necessary for the treatment of dry and dehydrated skin, both in adults and in children.

The cream - 5%, is produced in an aluminum tube with a sealed hole, a dosage of 25 and 50 grams.

The main properties of the cream:

• Prevention of diaper rash in children and adults
• Treatment for diaper rash.

[6], [7], [8]

Pharmacodynamics

Pharmacodynamics allows to determine the localization and mechanisms of the active substances of the drug, as well as their significance and effects under the influence of various factors. D-Panthenol is a drug that improves the regenerative capacity of tissues and is used for external use.

Descapanthenol is a derivative of panthenic acid, which refers to water-soluble B vitamins. This substance is necessary for fat, carbohydrate and protein metabolism of the skin. The substance plays an important role in gluconeonase and acetylation processes. It helps to release energy from carbohydrates, promotes the cleavage and synthesis of fatty acids, the synthesis of steroid hormones, the synthesis of sterols and acetylcholine.

To maintain normal functions of the epithelium, the pharmacodynamics of D-Panthenol is represented by pantothenic acid. With damage to the skin and tissues, the body lacks this substance. Pantothenic acid in D-Panthenol stimulates skin regeneration, increases the strength of collagen fibers and normalizes metabolism at the cellular level. And also has anti-inflammatory, moisturizing and regenerating properties. The excipients that make up the ointment and cream significantly improve the therapeutic properties of D-Panthenol.

[9], [10], [11]

Pharmacokinetics

Pharmacokinetics allows you to accurately assess the dynamics and stay of the drug and its metabolites in the body. That is, the pharmacokinetics of the drug allows you to investigate medicinal substances, through the influence of which you can develop an accurate method of dosing and the duration of use of the drug.

Low molecular weight and low polarity make it possible for the penetration of the drug to affect all layers of the skin. So, with topical application of D-Panthenol, the drug is absorbed very quickly and becomes pantothenic acid, which is associated with plasma proteins. During the application of D-Panthenol, the drug is absorbed very quickly through the mucous membrane and skin, penetrates into damaged tissues and promotes an increase in the metabolism of pantothenic acid.

[12], [13], [14], [15], [16], [17]

Dosing and administration

The way of application and the dose of the medicine depend on the disease, which should be cured by D-Panthenol. So, for the treatment of dermatitis, intertrigo, bedsores, mucosal defects and breast care, use D-Panthenol ointment or cream once or several times a day, depending on the doctor's recommendations and the complexity of the disease. If D-Panthenol is used to treat cracks in the breast nipples, then compresses and ointments should be done.

Regarding the choice of cream or ointment for use, everything is determined by the nature and characteristics of the surface on which the medicinal D-Panthenol is applied. So, for oily skin, ointment is recommended since it contains a high percentage of fat and is used to treat cracks in the skin and dry skin. But with moist wounds and burns, it is recommended to use a cream, since it does not contain fat. The cream is very easy to rub, therefore it is convenient for use at painful burns.

Doses of D-Panthenol - the substance is applied a thin layer on the affected area, from two to four times a day. If the ointment is used on the infected surface, then before using D-Panthenol it is recommended to treat the affected area with an antiseptic. Nursing mothers should lubricate the nipples of the breast after each feeding of the baby to prevent the formation of wounds and cracks on the chest. But babies should be smeared with D-Panthenol after water procedures and every change of clothes.

[23], [24]

Use of the d-Panthenol during pregnancy

Use during pregnancy is absolutely safe and allowed. Likarstvl does not have a negative impact on the development of the child, both in the early stages of pregnancy, and in the last months of gestation.

The only caution that pregnant women should observe when using the substance is the individual intolerance of the substances that make up the drug. But do not forget that during pregnancy, any use of medicines is not recommended, so if possible, replace D-Panthenol with safe alternative medicine methods.

Contraindications

Contraindications for use are based on intolerance of substances that are part of the drug. Also, the use of the substance in hypersensitivity to dexpanthenol, the auxiliary components of the drug and pantothenic acid is contraindicated.

[18], [19], [20]

Side effects of the d-Panthenol

Side effects are very rare, this happens with individual intolerance of the drug. The medicine can provoke local allergic reactions.

Also, side effects from:

• Appearance of itching
• Fine skin rash
• Skin dermatitis
• Erythema
• Eczema
• Hives

In medical practice, isolated cases have been reported, when the use of D-Panthenol caused side effects.

[21], [22]

Overdose

Overdose can cause a brief and minor allergic reaction. But because of low absorption, that is, absorption of the drug into the skin, an overdose is impossible.

Theoretically, if you take a large amount of medication inside, this can cause dyspepsia. In this case, symptomatic treatment is provided, that is, the entire process is reversible.

[25], [26]

Interactions with other drugs

Interaction with other drugs is allowed. In this case, special attention should be paid to the components of the interacting drugs. Since with the slightest intolerance of any substance, a very violent allergic reaction may occur.

To prevent this, before using D-Panthenol with other drugs, consult your doctor about the interaction of drugs and reactions to your body.

[27], [28], [29], [30]

Storage conditions

Storage conditions are standard for both preparations of this group. The drug should be stored in a place inaccessible to children and a place that is protected from high humidity.

One of the conditions of storage of D-Panthenol is compliance with the temperature regime. The temperature should not be above 25 degrees Celsius. Also, the drug should be stored away from light and direct sunlight.

[31], [32], [33]

Shelf life

The shelf life of D-Panthenol, which is set by the manufacturer, for the ointment form of the drug release should not exceed 2 years, and for the cream - no more than 18 months.

As soon as the medicine began to change its color or consistency, it must be disposed of. Since this indicates that D-Panthenol has lost its medicinal properties due to expired shelf life or improper storage conditions of the drug.

[34]