Abistan

Abistan is a corticosteroid medication, which is a combination of antibacterial and antifungal components; often used in dermatological practice.

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Indications Abistan

Abistan is used if the skin is affected by a fungus, if the patient has a superinfection due to bacteria. Superinfections include eczema (acute or chronic), hyperkeratosis (if the stratum corneum has become excessively thick), acute contact dermatitis, chronic hyperkeratical psoriasis, hypertrophic flat lichen.

Also in the instructions section Indications for use, Abistan recommend:

• with pemphigoid localization of scars (pemphigoid is a disease that is accompanied by blistery blisters);
• Keloid scars (when the postoperative growth of the scar begins);
• pretybial myxedeme (manifested as a goiter, and appears with an increased function of the thyroid gland.In the people it is called "Graves' disease");
• to suppress the inflammatory reaction after cryotherapy (cryotherapy is used for skin diseases, and liquid nitrogen is used during the procedure).

The cream is applied topically, directly to the affected area.

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Release form

The form of release of Abistan is a cream. It has a white color and is a soft consistency. Thanks to the creamy texture, the product is easily applied to the site of injury or injury. Abistan in the form of a cream - absorbs not very quickly, while it penetrates well through the skin, evenly distributing medicinal substances to the affected area. The cream is for external use only.

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Pharmacodynamics

What are the biochemical and physiological effects of Abistan?

Pharmacodynamics of abistan cream is that clobetasol propionate is used for topical use. It penetrates into the cell membrane and binds to glucocorticoid receptors. In connective, lymphoid, muscular and adipose tissue, abistan has a powerful anti-catabolic effect. As for clobetasol, it has anti-inflammatory, anti-allergic and immunosuppressive effects. When it is applied, edema, hyperemia, and itching on the skin are significantly reduced. Gentamicin sulfate (antibiotic, which is contained in the drug), has a pronounced bactericidal effect against many microorganisms.

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Pharmacokinetics

What is the chemical and biological process in the body, when using a drug such as abistan? Pharmacokinetics is as follows: when applied to the surface of the intact skin of clobetasol propionate adsorbed no more than 5%. If the skin has a small inflammatory process - it increases the penetration of clobetasol into the body, but not the most.

Gentamicin is not adsorbed very much. It has the property of binding to plasma proteins (up to 10%), and its half-life lasts from 2 to 4 hours. The drug is not metabolized, and is excreted from the body mainly with urine.

Also, the pharmacokinetics of abistan cream is that when the drug is applied to the skin, miconazole is almost not absorbed, and does not enter the systemic bloodstream.

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Dosing and administration

Since abistan is a means of external use, the way of application and dose is quite simple. The cream is applied 1 or 2 times a day. Applying abistan is required very thin layer on the skin. If you have hypertrophic lichen, a keloid cicatrix, a pretybial myxedema, then the drug can be applied in the form of an application, or under an occlusive (hermetic) bandage 1 time per day. If you resorted to cryotherapy, and want to prevent an inflammatory reaction, then abistan is applied 2 times a day for 3-4 days. And, in general, the treatment period is indicated by the doctor, being guided by the individuality of the case. If the remedy does not give the proper effect for 2-4 weeks, you need to consult a doctor and clarify the diagnosis. Perhaps, I need to adjust the treatment.

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Use Abistan during pregnancy

The use of abistan in pregnancy is absolutely safe. Also, if a woman is breastfeeding, you can use the drug. He absolutely does not do any harm and has no contraindications. After all, it is very important when carrying a fetus, not to be affected by harmful medications.

But it is better to consult a doctor. Because each organism is individual. Especially it concerns if the treatment is necessary to be carried out on the face skin.

Contraindications

The main contraindications for the use of abistan are:

- if the body has increased sensitivity to clobetasol propionate, gentamicin sulfate, as well as miconazole nitrate. Clobetasol propionate is a hormonal corticosteroid substance. Gentamycin sulfate belongs to antibiotics, and has a very wide spectrum of action. But miconazole nitrate - an element that has an antifungal and anti-inflammatory effect.

Also contraindication to the use of abistan is referred to as: skin tuberculosis, syphilitic skin lesions, skin reactions after vaccination. With skin cancer, this drug is particularly contraindicated.

It is not recommended to apply the drug if the skin has acne (acne), rosacea, perioral dermatitis and genital itching. If the skin is affected by the virus of herpes simplex, or chicken pox, as well as in the presence of fungus or bacterial skin infections.

This drug can not be used during pregnancy, and when breastfeeding. Contraindications have children under 12 years.

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Side effects Abistan

Do not use the drug for a long time. Side effects of Abistan are that this drug can cause skin atrophy, the formation of striae (stretch marks), telangiectasias, rashes, itching of the skin. Especially neatly, it is necessary to apply abistan on the skin of the face and on the folds of the limbs. If you are treating psoriasis or eczema, then it should be borne in mind that when applied to the face of abistan, atrophic changes in the skin will be more pronounced than, for example, in other areas of the skin. To prevent relapse in psoriasis, careful monitoring of the doctor is required. Also, avoid contact with abistan in the eyes. And if the drug is prescribed to children, then every week the doctor should conduct a dermatological examination.

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Overdose

Studies have shown that if abstane is topically applied, then an overdose of the drug is not observed. If you use abistan on a large area of the body, it can lead to absorption of the corticosteroid, and also cause such a phenomenon as hypercorticism. These reactions can occur with prolonged use. Corticosteroids are hormones that provide anti-inflammatory action. They are produced in small amounts in the adrenal cortex. As for the syndrome of hypercorticism - this disease occurs when the regular effect on the body of a large number of hormonal drugs.

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Interactions with other drugs

Interactions of Abistan with other drugs are not indicated.

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Storage conditions

Considering the storage conditions of abistan, it is best to store the cream at a temperature of up to + 25 ° C. The place should be dry, sun light should not get on the ointment. If the drug is overheated, it will go bad. Try to store the medicine in its original packaging. Since when the medicine is squeezed into a flask (or jar) not intended for storage of medical substances, the ointment quickly loses its healing properties. Special care must be given to children. Abistan should be kept in places not accessible to children. For example, on the shelf, which is located high or desirable, not in a prominent place.

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Shelf life

A very important part is the proper storage of medications. In this case, the expiration date of Abistan is not more than 2 years.

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