Abitor

Abitor is a drug that helps reduce cholesterol levels. And, as is known, cholesterol is deposited in the vascular system of the brain and heart, which complicates life. Abitor reduces cholesterol levels in the blood, which means it helps avoid heart attacks, strokes and hypertension, which are caused by high cholesterol levels. Let's take a closer look at the features of Abitor, how to use it and existing contraindications.

Indications Abitor

Indications for the use of Abitor include the use of the drug to reduce elevated levels of cholesterol and apolipoprotein.

Indications for use of Abitor:

• Hyperlipidemia
• Hypercholesterolemia
• Heterozygous hyperlipidemia

Abitor is prescribed to patients who have a high risk of developing a stroke or myocardial infarction, which can lead to cerebrovascular accidents. It is very important to monitor kidney and liver function indicators and regularly conduct urine and stool tests before starting to take Abitor.

Abitor, like other drugs, inhibitors can cause myopathy, which manifests itself as muscle pain, weakness, and elevated body temperature. In rare cases, during the administration of Abitor, patients experience an increase in creatine phosphokinase levels. The entire period of use of Abitor should be under the supervision of the attending physician. In case of symptoms of myopathy, the use of the drug must be stopped. During the administration of Abitor, patients are prescribed a strict hypocholesterolemic diet, which improves the absorption of the drug by the body and increases its preventive functions.

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Release form

Release form of Abitor tablets:

• round, biconvex, film-coated tablets of grey colour with a heart-shaped embossing on one side and smooth on the other (10 mg);
• round, biconvex, film-coated tablets of light orange color, smooth on both sides (20 mg).

1 tablet of abitor is coated with a film containing atorvastatin calcium, equivalent to 10 and 20 mg. Calcium carbonate, microcrystalline cellulose, lactose, iron oxide (black, red, yellow) and other substances are used as auxiliary substances.

Pharmacodynamics

The pharmacodynamics of the abitor is an interaction of many drugs. Thus, the pharmacodynamics of the abitor is represented by atorvastatin calcium, which is a synthetic, hypolipidemic agent. In other words, it is an enzyme that allows you to suppress the synthesis of cholesterol in the liver. Suppression of cholesterol in the liver helps to reduce the intracellular amount of cholesterol. And this, in turn, leads to an increase in the capture of cholesterol from the blood and the restoration of intracellular cholesterol homeostasis.

Atorvastatin works to lower blood cholesterol levels, especially in patients with heterozygous and homozygous familial hypercholesterolemia, mixed dyslipidemia and non-familial forms of hypercholesterolemia. The pharmacodynamics of the atorvastatin is responsible for lowering blood cholesterol levels due to atorvastatin, lowering triglyceride levels and increasing apolipoprotein A levels.

Pharmacokinetics

The pharmacokinetics of Abitor is based on the effective work of all components that are part of the drug. The main active substance of Abitor is atorvastatin, which has increased absorption into the blood and is maximally concentrated in plasma 1-2 hours after administration.

The use of food, simultaneously with the use of the drug significantly reduces the absorption of the latter from 9 to 25%. If the drug is taken at night, its pharmacokinetics are lower, compared to taking the drug in the morning and on an empty stomach. Atorvastatin is 98% bound to blood plasma proteins. The highest therapeutic effect during the use of atorvastatin is noted after 14 days of continuous use of the drug.

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Dosing and administration

The method of administration and dosage of Abitor depend entirely on the age and complexity of the disease of the person to whom the drug is prescribed. Please note that before starting treatment, it is necessary to follow a hypocholesterolemic diet.

The method of administration and dosage of Abitor for adults is 10 mg once a day, and the therapeutic dose is from 10 to 80 mg per day. The drug should be taken once a day at any time, preferably before and after meals. Please note that the dose of the drug should be determined by the attending physician, depending on the level of cholesterol in the blood. Also, during the use of the drug, it is necessary to monitor the level of lipoproteins in the blood. This allows you to control the dose of the drug. The maximum daily dose of the drug is 80 mg.

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Use Abitor during pregnancy

The use of abitor during pregnancy has not been thoroughly studied. Therefore, it is not possible to accurately predict the outcome of treatment and the effect of the drug on the course of pregnancy and the fetus.

Abitor is prescribed during pregnancy only in cases where the risk to the fetus is not considered, since the benefit of treatment for the mother is important. As for the use of Abitor by nursing mothers, the drug gets into breast milk, although not in large quantities. Therefore, when taking Abitor in the postpartum period, you should stop breastfeeding. The safety and effectiveness of the drug in children has not been studied.

Contraindications

Contraindications to the use of Abitor are based on hypersensitivity to any ingredient that is part of the drug. This includes liver disease, increased levels of transaminase activity in the blood and unknown etiology. The drug is also prohibited for use during pregnancy and breastfeeding.

Contraindications for the use of abitor with caution are prescribed to patients who abuse alcohol and have liver disease. The drug is prescribed with caution to women of reproductive age and those who use contraceptives.

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Side effects Abitor

The side effects of the abitor are:

• Constipation
• Dyspepsia
• Nausea
• Flatulence
• Abdominal pain
• Myalgia
• Diarrhea
• Asthenia
• Headache
• Allergic reactions
• Insomnia

In some cases, in addition to the side effects described above, the following is possible:

• Dizziness
• Pancreatitis
• Vomit
• Myopathies
• Hepatitis
• Paresthesia
• Skin rashes
• Hypoglycemia
• Itching
• Hyperglycemia
• Jaundice

Side effects of the drug should be monitored by the attending physician, and in particularly severe cases, the use of the drug should be discontinued.

Overdose

An overdose of Abitor may occur if the prescribed dosage of the drug and time of administration are not followed.

Symptoms of an overdose of Abitor:

• Myopathy
• Neuromuscular excitability
• Vomit
• Impaired liver function
• Myoclonus
• Disturbances of consciousness
• Nausea
• Diarrhea

In order for the symptoms of an overdose of Abitor to go away, you must contact your doctor and stop using the drug.

Interactions with other drugs

Interaction of abitor with other drugs is possible, but only under the supervision of the attending physician. It is prohibited to take abitor with oral antacid suspensions that contain magnesium and aluminum hydroxides.

It is necessary to monitor the condition of patients who use abitor. Especially the use of abitor with:

• Erythromycin
• Larntromycin
• Azithromycin
• Atorvastatin
• Terfenadine

Also, caution should be exercised when using atorvastatin with oral contraceptives that contain norethindrone and ethinyl estradiol. As well as the interaction of atorvastatin and protease inhibitors, which increase the concentration of atorvastatin in plasma.

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Storage conditions

Abitor must be stored in the original packaging, out of the reach of children, at a temperature not exceeding 25 °C.

If the storage conditions of Abitor are not observed, the drug may deteriorate, change its color and properties. It is very important not to take Abitor with other drugs, as this will lead to irreversible side effects.

Shelf life

The shelf life of Abitor is 2 years from the date of manufacture, which is indicated on the packaging with the tablets. Please pay attention to what the tablets are, any color changes in the drug indicate non-compliance with storage rules or expiration of the drug. Abitor is dispensed only with a prescription from a doctor.