Ibuprom sprint in capsules

Ibuprom sprint in capsules is a non-steroidal anti-inflammatory drug (NSAID) with elements of anesthesia, which has the Latin name Ibuprom Sprint Caps, as well as the name International Ibuprofen. The main active substance of the drug is ibuprofen.

Indications Ibuprom sprint in capsules

Possessing anti-inflammatory and analgesic characteristics, indications for use Ibuprom sprint in capsules has a fairly wide range of action.

• Symptomatic relief of dental and headache.
• Premenstrual and menstrual symptoms.
• Muscle pain caused by a cold.
• Fever, concomitant infectious and catarrhal diseases.
• Pathology of the musculoskeletal system, the source of which is the focus of inflammation: neuralgia, arthritis, bursitis, tendovaginitis of various genesis and others.
• Osteochondrosis, sciatica.
• Migraine.
• Myalgia is a muscle pain developing in connection with the hypertonicity of muscle cells, both in a calm state and under tension.
• Arthralgia - pain in the joints.
• Ossalgia - "pain in the bones".
• Pain symptomatology after a suffered trauma or surgical intervention, accompanied by inflammation.
• Algodismenorea is an inflammatory process in the pelvic organs.
• Childbirth: Ibuprom uses sprint capsules as a tocolytic and analgesic.

[1]

Release form

The form of the drug is capsules of oval form, with a soft transparent shell of blue color. "Filling" is an oily transparent or slightly bluish substance containing 0.2 g of ibuprofen active substance. The drug has prolonged properties.

[2]

Pharmacodynamics

The active component of the drug and dictates what is the pharmacodynamics of Ibuprom sprints in capsules. The analgesic effect of a non-steroidal anti-inflammatory drug (NSAID) is obtained by inhibiting, inhibiting the formation of prostaglandins. Ibuprom muffles the intensity of pain manifestations, contributes to the relief of edema and the reduction of high body temperature. Due to its prolonged characteristics, a prolonged action of the drug is observed. The active substance effectively inhibits the aggregation of platelets (the ability of platelets to join - "gluing" the blood platelets) caused by collagen and adenosine diphosphate (ADP). Antipyretic properties Ibuprom sprints in capsules (antipyretic characteristics) are manifested in the effect of the drug on the cells of the hypothalamus.

The analgesic property of the drug is due to the arrest of the inflammatory process, a decrease in the synthesis of bradykinin and a decrease in the algogenicity of this chemical compound.

Anti-inflammatory nature of the drug is obtained in connection with a decrease in vascular permeability, activation of blood microcirculation, as well as blocking sources of energy supply of inflammation.

When administered orally, Ibuprom sprints in capsules penetrates into the gastric mucosa insignificantly, while the main component of the drug is absorbed already in the small intestine. In this case, the maximum concentration of the base substance in the blood plasma is reached after one to two hours. In the case of rheumatoid manifestations of the inflammatory process, ibuprofen reduces pain symptoms, stops the growth of puffiness, relieves joint stiffness.

Influencing the brain receptors responsible for the thermal regulation of the body, the drug manages to cope with the high temperature of the patient's body, demonstrating antipyretic characteristics. The effectiveness of the drug and the duration of its action depends on the starting temperature and the administered dosage. If the drug is administered once, then its effect can be observed for eight hours.

When menstrual pains in a woman caused by dysmenorrhea not of organic origin (primary dysmenorrhea) Ibuprom sprints in capsules reduces intrauterine pressure and intensity of muscular contractions of the uterus, which contributes to the relief of pain.

[3]

Pharmacokinetics

Metabolization of ibuprofen occurs almost entirely in the liver, with about 90% of the drug being disposed of by the kidneys and excreted together with urine in unchanged form or in the form of metabolites, partially secreted with bile. In the case of oral administration of the drug, the maximum concentration of the active substance in the blood plasma (Cmax) is observed even one to two hours after administration.

Pharmacokinetics Ibuprom sprints in capsules, confirmed by test studies, showed that in healthy people the half-life of the drug (T½) is about one hour forty minutes. In patients who have a history of kidney and / or liver disease, this indicator varies from 1.8 to 3.5 hours. High switching of the active substance to plasma proteins is noted - this index approaches 100.

[4], [5]

Dosing and administration

Ibuprom Sprint in capsules is prescribed for adults and children over 12 years of age, and also having a body weight of more than 40 kg. Single dose of the drug is one to two capsules, corresponding to 0.2 - 0.4 g of ibuprofen. The drug should be taken every four to six hours. Within a day, do not exceed the total dose of the drug in 1.2 g, which equals six units. For patients of retirement age, dosage adjustment is not required, except in cases where a history of the patient has been diagnosed with renal or hepatic insufficiency. The capsule of the preparation is swallowed whole: either with food (this is especially true for patients who have a hypersensitivity to the stomach), or after eating with a sufficient amount of water.

The way of application and dose of the drug for children whose weight is less than 40 kg is selected individually. The maximum daily amount of ibuprofen is calculated as 20-30 mg per kilogram of body weight of a small patient. This figure is divided into three to four methods, the interval between them should be six to eight hours. Exceed the permissible dose of the drug is not worth it, since it is fraught with serious complications.

• For children whose body weight falls from 30 to 39 kg, a starting amount of 0.2 g (one capsule) is recommended. The maximum dosage during the day is 0.8 g of ibuprofen, which is equivalent to four capsules.
• For babies, whose body weight is in the range of 20 to 29 kg, a starting dosage of 0.2 g (one capsule) is recommended. The maximum dosage during the day is 0.6 g of ibuprofen, which is the equivalent of three capsules.

[8], [9], [10]

Use Ibuprom sprint in capsules during pregnancy

Any medicines should be used with extreme caution in the period when a woman is expecting the birth of her child. Using Ibuprom sprints in capsules during pregnancy is only permissible in the last third trimester, when the fetus is already formed. During the first and second trimester of pregnancy, the drug can be prescribed to a woman only in the case of a real advantage of the benefits that the mother's body will receive in comparison with the likely negative consequences for the fetus.

The active substance of the drug in small amounts falls into the mother's milk, but it is still acceptable during lactation. But if there is a medical need for long-term treatment or the administration of large doses of the drug, in this case it is worthwhile to raise the issue of stopping breastfeeding.

Contraindications

Even if the drug seems innocuous enough at first glance, treat its administration, and especially dosages, is very carefully. Contraindications to the use of Ibuprom sprints in capsules, are also quite diverse:

• Hypersensitivity to ibuprofen or other components of the drug.
• Bleeding, taking place against the background of ulcerative lesions of the stomach, flowing directly at the time of the necessary therapy or which was previously two or more times. Period of exacerbation of the disease.
• Symptoms of an allergic reaction to the drug:
  • Rhinitis.
  • Rashes.
  • Hemorrhagic diathesis.
  • Edema of the Quincke.
• Introduction Ibuprom sprints in capsules together with other NSAIDs. This applies to specific inhibitors of COX-2.
• Perforation of the walls and mucosa of the upper sections of the gastrointestinal tract. Probability of bleeding.
• Ischemic heart disease (IHD), as well as a severe form of hepatic, cardiac and / or renal failure.
• Bleeding cerebrovascular nature, another active species, as well as unexplained etiology.
• Babies, whose body weight has not reached twenty kilograms or the age of up to two years.
• When dehydration (dehydration) of the body, provoked by vomiting, small volumes of fluid intake, as well as manifestations of diarrhea (watery diarrhea).
• Bronchial asthma.
• Pathological abnormalities of porphyrin metabolism, obtained genetically or in the womb (for example, severe intermittent porphyria).
• Recurrent polyposis of paranasal sinuses and other nasal tissues.
• Pathological abnormalities in the process of blood coagulation.
• Rehabilitation period after aortocoronary bypass surgery.

[6], [7]

Side effects Ibuprom sprint in capsules

It is worth mentioning the side effects of Ibuprom sprint capsules, which can occur against the background of its reception:

• Confusion and hallucinations.
• Impairment of appetite.
• Bronchospasm.
• Allergic reaction to the drug:
  • Hives.
  • Rhinitis.
  • Swelling of the lingual plate, larynx.
  • Rash on the skin.
  • Anaphylactoid manifestations: Quincke's edema, anaphylaxis, up to shock manifestations.
• Reduced blood pressure.
• Headache.
• Strengthening the work of the sweat glands.
• Enhanced palpitations.
• Violations in the organs of sight and hearing.
• Pain in the epigastric region.
• Failures in the work of the hematopoiesis system.
• Nausea, heartburn and vomiting.
• Stomatitis and dryness of the oral mucosa.
• Hepatitis.
• Exacerbation of diseases in the organs of the digestive tract.
• Internal bleeding, which, if not given urgent medical attention, can lead to death. This especially applies to persons of retirement age.
• Exacerbation of diseases of the genitourinary system.
• Dizziness.
• Flatulence and diarrhea.
• Bad dream.
• Increased irritability and depressive state.
• Myocardial infarction.
• Emotional instability.
• Insufficiency of cardiac activity.
• Failures in the work of the liver, especially with prolonged intake of Ibuprom sprints in capsules.
• Increase in the amount of urea in the plasma.
• Pancreatitis.
• Liver failure.
• Anemia of various etiologies.
• Lesions of a dermatological nature.
• Autoimmune disorders.
• It can provoke an attack of bronchial asthma.

Overdose

If the situation has turned out and the patient has taken an excessive amount of ibuprofen, his body can trigger a response symptomatology, which depends on the dose of the drug administered and the time interval that has passed since the taking of the excessive dosage. Overdose Ibuprom sprint in capsules may manifest symptoms:

• Pain in epigastrium.
• Nausea, high intensity of which can provoke and vomiting.
• Pain manifestations in the head.
• Begins to accompany an unpleasant noise background.
• Sleep and appetite disturbance.
• Dizziness.
• Diarrhea.
• Internal bleeding.
• Change of mood.
• Spatial disorientation.
• Arterial hypotension.
• Exacerbation of bronchial asthma.
• Elevated temperature indices of the body.
• Convulsions.
• Arrhythmia.
• Failures in the work of the respiratory system and the work of the kidneys.
• Increased prothrombin index.
• Hemolytic anemia is noted.
• Thrombocytopenia, granulocytopenia.

To stop the pathological symptoms, you need to call an ambulance. Before her arrival, if after an overdose less than an hour has passed, the first aid should be given to the patient:

• Provoke vomiting. This allows at least partially to clean the stomach of the excess drug.
• Using an enema, rinse the stomach.
• Give an activated carbon or any other sorbent to drink.

There is no single-purpose antidotes in the treatment of an overdose of ibuprofen at this time.

[11], [12],

Interactions with other drugs

Earlier, a warning was sounded about the cautious admission of the drug, the measured dosage for each specific case. Even more vigilant to be with complex therapy. Interactions Ibuprom sprints in capsules with other drugs are rather ambiguous. In some cases, two drugs can enhance each other's action, while in others they can become antagonists.

Ibuprom sprints in capsules are contraindicated for joint use with other drugs related to non-steroidal anti-inflammatory drugs (NSAIDs), as well as with acetylsalicylic acid, preventing the emergence of side symptoms. Joint use of ibuprofen with glucocorticoids or anesthetics is capable of provoking gastrointestinal bleeding, and also increases the risk of the occurrence of an eczema and ulcers on the mucosa of the digestive system.

Ibuprofen reduces the effectiveness of antihypertensive drugs and drugs with diuretic properties. When combined with drugs that inhibit the process of blood coagulability, mandatory monitoring of this indicator is necessary.

Methotrexate and Ibuprom sprints in capsules are capable of provoking pronounced side effects. In the case of using ibuprofen together with zidovudine, the probability of hemarthrosis and hemorrhage (hematoma) increases, especially in patients who are HIV-infected. Tandem with digoxin makes it possible to obtain an increase in the quantitative indices of the active substances of medicament preparations in the blood plasma.

Ibuprom sprints in capsules and antithrombotic drugs provoke the occurrence of gastrointestinal bleeding. Tandem with antibiotics of the quinoline group can provoke a convulsive syndrome. Therapeutic therapy with ibuprofen and sulfonylurea requires a constant check of the quantitative index of glucose in the blood plasma. Complex treatment with the use of anticoagulants enhances the effect of the latter.

After the administration of mifepristone, it is necessary to withstand 8 to 12 hours before any NSAIDs are used, including Ibuprom sprints in capsules, since sharing will stop the effect of the first drug. It is strictly forbidden to take ibuprofen with cardiac glycosides. This combination negatively affects the human body, provoking heart failure, an increase in the number of glycosides in the serum, inhibiting the intensity of glomerular filtration. Reduce the ability of ibuprofen to absorb such drugs as colestyramine or antacids. The analgesic characteristics of the drug in question can enhance caffeine.

Storage conditions Ibuprom sprint in capsules A cool place, with a temperature not exceeding 25 ° C, protected from direct sunlight - these are the basic conditions for storing Ibuprom sprints in capsules. The drug should not be available to children.

[13], [14], [15]

Shelf life

Two years (or 24 months) is the shelf life of the drug, indicated on its packaging. It is recommended to carefully monitor the end date of suitability and after this date, it is not necessary to take an expired medication.

[16], [17]