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Ibupromus sine

, medical expert
Last reviewed: 23.04.2024
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Ibuprom sinus is a combined drug that provides analgesic, anti-inflammatory and anti-pyretic action, as well as reducing swelling of the mucous membrane of the nasal cavity and its adnexal sinuses. The synonym is Ibuprom Sprint Caps.

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Indications Ibupromus sine

This drug is intended for short-term symptomatic therapy of colds, acute respiratory infections and influenza accompanied by headache, sore throat, muscle pain (myalgia), fever, inflammation of the nasal mucosa and paranasal sinuses and rhinitis.

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Release form

The form of the preparation is a tablet. In the composition of one pill 200 mg of ibuprofen and 30 mg of pseudoephedrine hydrochloride will be restrained.

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Pharmacodynamics

Pharmacodynamics Ibuprom sine is associated with blocking ibuprofen (non-steroidal anti-inflammatory drug, isobutylphenyl-propionic acid derivative) cyclooxygenase enzyme, which leads to a reduction in the synthesis of prostaglandins - lipid mediators of pain, inflammation and body temperature reaction.

Pseudoephedrine in the form of hydrochloride stimulates alpha and beta adrenoreceptors of small vessels of the mucous membrane of the respiratory tract, which leads to their narrowing. As a result, the vascular permeability and swelling of the mucous tissues of the nasal cavity decreases, the nasal passages increase, the outflow of secretions from the paranasal sinuses improves, and respiration through the nose is restored.

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Pharmacokinetics

After ingestion Ibuprom sinus is absorbed into the gastrointestinal tract and enters the bloodstream, the therapeutic effect is felt on average 20-25 minutes after taking the drug, and its duration is from 4 to 6 hours.

The maximum concentration of ibuprofen in the blood plasma is noted 1-2 hours after administration. The drug is metabolized in the liver, the metabolites are excreted by the kidneys (with urine); About 1% of ibuprofen and 55-75% of pseudoephedrine are removed from the body in unchanged form.

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Dosing and administration

Preparation Ibuprom sinus is used inside - before eating, squeezed with water. The recommended dosage for adults and children over 12 years is 1-2 tablets every 4-6 hours. The maximum daily dose is 6 tablets (1.2 g).

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Use Ibupromus sine during pregnancy

The use of Ibuprom sinus during pregnancy and lactation is contraindicated.

Contraindications

Among the contraindications to the use of Ibuprom sinus appear:

  • individual hypersensitivity to the components that make up the drug;
  • insensitivity of acetylsalicylic acid;
  • propensity to allergic reactions in the anamnesis;
  • bronchial asthma;
  • ulcer of the stomach and duodenum in the stage of exacerbation;
  • presence in the anamnesis of gastric bleeding;
  • acute renal or hepatic insufficiency;
  • serious violations of the cardiovascular system;
  • angle-closure glaucoma;
  • diabetes;
  • increased level of thyroid hormones (hyperthyroidism);
  • pheochromocytoma (tumor of adrenal tissue);
  • hyperplasia (adenoma) of the prostate;
  • age up to 12 years.

When taking this medication, care must be taken when driving vehicles and production mechanisms.

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Side effects Ibupromus sine

The most common side effects of Ibuprom sinus are:

  • headaches and dizziness;
  • skin rashes in the form of urticaria, itching of the skin;
  • heartburn, epigastric pain, nausea, vomiting, indigestion;
  • shortness of breath, increased heart rate, increased blood pressure;
  • increased excitability, sleep disturbance;
  • dysuria (urinary retention), edema;
  • decreased appetite;
  • hyperhidrosis (increased sweating).

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Overdose

Overdose of this drug causes nausea and vomiting, headache and stomach pain, drowsiness, tinnitus, heart rhythm disturbances. A significant overdose exceeding 400 mg / kg of body weight can lead to atrial fibrillation, a drop in blood pressure, hyperthermia, increased acidity (acidosis), impaired breathing, leading to a coma.

Long-term use of ibupromus sine may cause pathological changes in the blood: increased disintegration of red blood cells (hemolytic anemia), a decrease in the number of granulocytes (granulocytopenia), and a decrease in platelet count (thrombocytopenia).

In cases where acute signs of an overdose appear within 1 hour of taking the drug, you should induce vomiting, rinse the stomach or take activated charcoal. Treatment of the effects of an overdose is symptomatic.

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Interactions with other drugs

The key interactions of Ibuprome sine with other drugs are that its use excludes the use of other non-steroidal anti-inflammatory drugs (NSAIDs) and acetylsalicylic acid (aspirin) - because of the threat of side effects.

Ibuprom sinus reduces the therapeutic effect of certain hypotensive and thiazide diuretics. With the simultaneous use with drugs of a group of coumarin anticoagulants, which reduce blood coagulability, their effect is enhanced.

Ibuprom sinus increases the toxicity level of the antitumor drug-cytostatic methotrexate. When combined with medicines digitalis (digitalis) can cause cardiac arrhythmia; with preparations containing corticosteroid hormones - increases the risk of gastrointestinal bleeding;

The intake of Ibuprom sinus and lithium drugs used in psychiatry (psychotropic drugs) leads to an increase in the concentration of lithium in the blood and the occurrence of its side effects.

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Storage conditions

Storage conditions Ibuprom sine: at a temperature of + 18-25 ° C.

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Shelf life

Shelf life of the drug is 2 years.

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Attention!

To simplify the perception of information, this instruction for use of the drug "Ibupromus sine" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

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