Hartman's solution

Hartman's solution is a drug that is prescribed with a decrease in blood circulation, violations of the acid-base balance of the body, and a number of other indications. Let's consider the features of this drug, methods of application, dosage, contraindications, as well as interaction with other medicines.

Hartman's solution, like other medicines, is taken only for medical reasons. The drug is administered drip, in the form of infusions. As a rule, Hartman solution is used for treatment in hospitals, less infusions are done at home.

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Indications Hartman's solution

Indications for the use of Hartman Solution are based on medical indications and medical recommendations. The drug is prescribed for:

• Severe dehydration in the normal acid-base balance;
• Hypovolemia;
• Weak acidosis;
• To compensate for water deficiency and electrolytes (due to diarrhea, burns, vomiting, peritonitis and other severe infections);
• To maintain extracellular fluid after surgical operation or during surgery. In this case, the use of Hartman's solution makes it possible to delay blood transfusion;
• For the treatment of significant blood loss, shock and traumatic conditions.

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Release form

The form of the preparation - glass bottles of 500 ml and 1000 ml. The composition of the drug includes calcium chloride, a solution of sodium lactate, potassium chloride, hydrochloric acid, sodium chloride and water for injection.

This form of Hartman's release of the infusion solution is very convenient for drip administration. For use in a hospital, Hartman solution is produced in plastic bottles. Such a form of release does not require special conditions for transportation and storage, in contrast to the glass bottles of this drug. One package contains 10 Hartman bottles of solution.

[4], [5], [6], [7], [8]

Pharmacodynamics

Pharmacodynamics Hartman solution is the active substance of the drug and the processes that occur with them after ingestion. In its osmolarity and composition, Hartman's solution refers to extracellular fluid. This is why the drug is used to recover electrolytes and liquids. Another purpose of the drug is the regulation of the acid-base balance.

Hartmann's solution works much more efficiently than the infusion solution of sodium chloride. The drug provides compensation for the most important cations for the human body in the extracellular fluid - (K ⁺  Na ⁺ Ca ²⁺ ). The active substance of the drug is lactate, it is metabolized in the body to bicarbonate. Hartman's solution has an alkalizing effect.

[9], [10]

Pharmacokinetics

Hartman's pharmacokinetics are solutions for the introduction, spread, metabolism and excretion of the drug. After an internal drip, Hartman's solution very quickly increases blood osmolarity. The drug does not stay in the blood for a long time, and after 30-40 minutes it goes into the tissues. The components of the drug are excreted in the urine.

Infusion Hartman solution has a beneficial effect on the body. The drug is practically not metabolized, therefore does not affect the functioning of the body's systems. As a rule, the drug is used for inpatient treatment, observing the patient's condition at the time of drug administration.

[11], [12], [13]

Dosing and administration

The method of administration and dose of the drug is prescribed by the attending physician. When using the drug in the form of infusions, the average speed of drip administration should be at the level of 60 drops per minute, up to 2500 ml per day, that is, 2.5 ml per kg of patient weight. If the drug is used in emergency conditions, the rate of administration should be up to 100 drops per minute, and the volume of the drug administered depends on the patient's condition.

Please note that within 24 hours after the use of Hartman solution it is necessary to provide the body with a daily fluid demand. Replenish the volume of liquid is necessary and for the next two days. This will completely fill the fluid deficit in 72 hours.

[22], [23],

Use Hartman's solution during pregnancy

The use of Hartman Solution during pregnancy is not recommended. Hartman's solution, like any medication is not desirable for use during pregnancy. The drug is not recommended for use in early pregnancy, as it can cause a miscarriage. The use of Hartman's solution in the last months of pregnancy is a direct threat to premature birth and complications during the birth process.

The use of Hartman's solution during pregnancy is only possible for medical reasons, in the event that the potential benefit to the mother is much more important than the risk to the child. The drug is not allowed to use during the lactation period, because the active ingredients of Hartman's preparation with the mother's milk get into the blood of the child.

Contraindications

Contraindications to the use of Hartman's solution are based on individual intolerance to the active components of the drug and increased sensitivity to their action. The main contraindications to the use of Hartman's solution are: hypertonic dehydration, cardiac and renal insufficiency, arterial hypertension, hyperlactacidemia and other diseases.

With special care, Hartman solution is prescribed for acute dehydration, respiratory failure, giporteinemii, in the treatment of corticotropin and glucocorticosteroids.

[14], [15], [16], [17], [18]

Side effects Hartman's solution

Side effects of Hartman's solution are due to improper dosage of the drug. Occurrence of side effects is possible and when using the drug by patients who have contraindications. So, the main symptoms of the side effect of the Hartmann infusion solution are:

• Allergic reactions to the skin;
• Hypervolaemia;
• Anxiety;
• Hyperchloremia;
• Thrombophlebitis;
• Hyperhydration.

If side effects occur, discontinue use of the drug or reduce dosage. It is mandatory to seek medical help for the treatment of painful symptoms of side effects.

[19], [20], [21]

Overdose

A Hartman overdose solution may occur due to a high dosage of the drug or a high rate of its administration. In case of an overdose, it is possible to disturb the balance of water and electrolytes in the body, as well as cardiopulmonary decompensation. In this case, the patient is stopped to administer Hartman's solution and performs symptomatic therapy.

In especially severe cases of overdose, patients are prescribed drugs that will bring to zero the action of Hartman's solution. Obligatory is the process of replenishing the liquid, that is, compliance with the drinking regime to ensure the normal functioning of the organ system.

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Interactions with other drugs

The interaction of Hartman solution with other drugs is possible only with the permission of the doctor. Thus, with the simultaneous use of non-steroidal anti-inflammatory drugs, estrogens, mineralocorticoids, anabolic hormones, vasodilators and Hartman solution, sodium retention in the body is possible.

With the interaction of Hartman's solution with angiotensin-converting enzyme inhibitors, potassium preparations and diuretics, hyperkalemia may develop. In combination with cardiac glycosides, the toxicity of the latter drugs increases. If Hartman's solution interacts with salicylates, it is possible to increase the alkalinity of urine, as well as slow the withdrawal process.

[27], [28], [29], [30], [31], [32],

Storage conditions

The storage conditions of Hartmann's solution are described in the drug's instructions and are no different from the rules for storing other infusion liquids. The drug should be stored in a dry, dark, cool and inaccessible place for children. It is important to comply with the temperature regime - from 15 to 25 ° C.

When storing and transporting Hartman solution in glass bottles, it is very important to be careful. But the storage conditions of Hartman solution in plastic bottles require compliance with the temperature regime. Please note that failure to comply with the storage conditions of the drug will result in the loss of its medicinal properties, and therefore inefficiency in the treatment process.

[33], [34], [35], [36], [37], [38],

Shelf life

Hartman's shelf life of the solution is 3 years from the date of manufacture of the medicinal product, which is indicated on the package of the preparation. After the expiration date, the drug must be disposed of. Use of an expired infusion solution is strictly prohibited. Since the use of a spoiled preparation can lead to uncontrolled and irreversible negative health consequences and worsen a patient's condition.

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