Daivobet

Psoriasis is a disease that is hard to treat, as many drugs at best only bring temporary relief. However, therapeutic procedures must be carried out in order, at least, not to aggravate and aggravate the process.

 One of the drugs of choice for this pathology may become Dayvobet - a combined antipsoriatic agent of the group of glucocorticosteroids.

[1]

Indications Daivobet

This drug is used in the chronic course of vulgar plaque psoriasis, which affects the skin and scalp.

[2]

Release form

Daivobet can be produced in several medical forms:

• external cream (consists of 50 μg calcipotriol and various auxiliary substances);
• external solution (consisting of 52.2 μg calcipotriol hydrate and additional substances);
• external ointment, tube 15 g, 30 g or 60 g (ointment consists of 0.05 mg calcipotriol, 0.5 mg betamethasone and some additional substances).

The most often used is an ointment, which is a homogeneous substance of a white or cream shade that does not have a specific smell.

[3]

Pharmacodynamics

The active element of the ointment, calcipotriol, is a synthetic preparation of the active product of the metabolism of natural vitamin D. It helps inhibit the proliferation of cells of the outer layer of the skin, and their morphological differentiation is significantly accelerated. Also, the active substance has a small effect on the metabolic processes of calcium in the body.

The properties of betamethasone are aimed at reducing the signs of inflammation, relieving itching, enhancing local immunity, strengthening the vascular network at the site of the lesion. The precise mechanism of the effect of the drug has not yet been clarified.

[4]

Pharmacokinetics

Absorption of active substances of the drug through the skin is 1-5% of the applied dosage. Due to the limited absorption of this drug, its effect on the body is exclusively local. The percentage of absorption of the drug can be increased by applying an occlusive dressing over the ointment. In the tissues the drug is delayed for several days.

The metabolites formed in the liver are not pharmacologically active, the time of partial elimination is short. Active substances as metabolites are excreted from the body through the urinary system and with feces.

Dosing and administration

Ointment Daivobet is a drug for external use. In psoriasis, it is sufficient to apply it on the affected skin with a small layer once daily. It is not recommended to use more than fifteen grams of the drug per day.

The therapeutic course should last at least 1 month. Further use of the drug should be agreed with the doctor.

With extensive psoriatic lesions of the skin (more than 30%), it is recommended to refrain from using Daivobet in favor of another drug that can be prescribed for the treatment of total psoriasis.

[7], [8]

Use Daivobet during pregnancy

The disease with psoriasis does not increase the risk of miscarriage or early labor, does not provoke the development of congenital anomalies of the fetus. However, the use during pregnancy of some antipsoriatic drugs, including Daivobet, may present a certain degree of risk to the gestation process.

There is no reliable information about the dangers of this medication for pregnant women, so the doctor should determine the expediency of taking the drug.

It should be noted that most experts are inclined to believe that it is not necessary to prescribe the treatment of psoriasis during pregnancy without extreme necessity: it is better to wait with therapeutic measures until the end of the lactation period.

Contraindications

Among the contraindications to the use of this drug can be identified as follows:

• disturbance of metabolic processes, disorders of mineralization of tissues, in particular, calcium metabolism;
• allergic sensitivity to any components of the drug;
• disorders of the functionality of the liver and kidneys;
• other concomitant skin lesions caused by viruses, fungal infection, bacteria and parasites;
• acne, dermatitis, tuberculosis and syphilitic skin lesions, ulcerous diseases of external skin, increased fragility of capillaries, phenomena of ichthyosis;
• other forms of psoriasis, except for vulgar;
• pregnancy and breastfeeding;
• the child's age of the patient.

Also, the drug is not recommended to be applied to the skin of the face and mucous membranes.

[5], [6]

Side effects Daivobet

The most common side effects are the appearance of itching rashes on the body, accompanied by a burning sensation and soreness.

Sometimes in the early stages of treatment measures the disease may worsen, but if the treatment does not stop, the symptoms gradually begin to fade.

There may be signs of irritation on the skin, redness, the formation of follicles and swelling at the site of application of the ointment.

In urine, there may be an excess of calcium.

Large doses of the drug can trigger a decrease in the functionality of the adrenal glands, as well as the development of the Itenko-Cushing syndrome.

Overdose

Overdosing with Daivobet can be caused by prolonged and uncontrolled treatment, often conducted independently, without the knowledge of the doctor.

Symptoms of overdose are an increase in the concentration of calcium in the circulating blood, oppression of the adrenal and pituitary system.

After the withdrawal of the drug, the symptomatology usually disappears, and the imbalance of systems and organs stabilizes.

Chronic intoxication with the drug requires a gradual and mild withdrawal of the drug.

Interactions with other drugs

It is not recommended to share the drug with other glucocorticosteroid drugs, in order to avoid the formation of dysfunction of the adrenal gland system-the pituitary.

It is not permissible to use the drug Daivobet with any external means based on salicylic acid.

[9], [10]

Storage conditions

When storing the drug, it is strictly unacceptable that it is heated above 25 ^° C.

 Do not leave the medicine in places accessible to children.

Shelf life

Shelf life of the ointment is up to 2 years, after this period, the unused product must be discarded.

[11], [12]