Retabolil

Retabolil contains the component nandrolone, which is an anabolic steroid with a prolonged type of activity. The androgenic effect of the element is weak; by itself, nandrolone is a derivative of testosterone, whose anabolic effect has a higher intensity.

Inside the drug, androgenic and anabolic indices are successfully combined - this allows it to be used in bodybuilding to gain muscle mass. The drug does not lead to the appearance of epidermal rash and spermatogenesis disorders, and also does not have pronounced hepatotoxicity. [1]

Indications Retabolil

It is used for the following disorders:

• muscle dystrophy , which is progressive;
• osteoporosis of a varied nature;
• restoration of normal protein metabolism after injuries or burns, as well as operations, radiation therapy and severe infections;
• glomerulonephritis;
• cachexia ;
• therapy for disseminated breast carcinoma in women;
• spinal muscular atrophy;
• increase in muscle mass (for bodybuilders);
• retinopathy of diabetic origin .

The drug can be combined with corticosteroids, cytostatics, and tuberculostatics.

Release form

The release of the drug element is made in the form of a liquid for intramuscular injections, inside ampoules with a volume of 1 ml. There is 1 such ampoule inside the box.

Pharmacodynamics

The medication helps to stimulate erythropoiesis; it increases the number of erythrocytes, hematocrit with hemoglobin, as well as the intensity and rate of protein binding.

It should be noted that the drug does not contain components of the C17-alpha-alkyl category that can provoke hepatic dysfunction and cause cholestasis. [2]

Pharmacokinetics

The medicine is gradually released from the injection area, after which it penetrates into the blood circulation. The half-life is 6 days. The metabolic processes of drugs are realized inside the liver. The main metabolic components are 19-norandrosterone, as well as 19-norepiandrosterone with 19-norethiocholonolone; they are excreted in the urine. The drug effect develops by the 3rd day after the introduction of the first portion.

Dosing and administration

The medication is used both for inpatient conditions and for outpatients. It is necessary to inject Retabolil by the intramuscular way, deeply.

The selection of the portion is made by the attending doctor, taking into account the characteristics of the disease. An adult is usually administered 25-50 mg of a substance 1 time per month.

For a child, the portion is calculated in the ratio of 400 μg / kg, and the frequency of administration corresponds to an adult. The medication can be prescribed by a doctor in pediatrics, if there is a vital need.

Administration of medication to persons with anemia.

The dosage size for a man is 0.2 g with the introduction of 1 time per week, and for a woman - 0.1 g with the same frequency. If there is no improvement after 6 months of therapy, the drug must be discontinued.

In case of severe kidney failure, the medication is administered at a dosage of 50 mg, weekly.

Persons with oncology require the use of 50 mg, 1 time per 5 days.

• Application for children

Prescription in pediatrics is prohibited (persons under the age of 18).

Use Retabolil during pregnancy

You can not use Retabolil for HB and pregnancy.

Contraindications

The main contraindications:

• breast cancer in men or prostate cancer;
• development of nephrotic syndrome due to prolonged use of anabolic steroids;
• the presence of metastases in people with cancer;
• the presence of allergies in relation to the elements of the medication;
• porphyria;
• hepatic pathologies of a severe nature.

Caution when using drugs is necessary in the case of epilepsy, cardiac dysfunction, migraine, kidney / liver disease and glaucoma, and in addition to this for diabetics and with increased blood pressure values.

Side effects Retabolil

When using the medication, taking into account all the instructions and recommendations, in the established therapeutic portions, side signs develop only occasionally. Prolonged administration of drugs can provoke such violations:

• symptoms of intolerance;
• vomiting, burning sensation in the area of the tongue, nausea;
• dysfunction associated with the ovaries (hyper- or hypofunction);
• epidermal rash and acne;
• hepatic pathologies and jaundice;
• retention of Na, liquid and nitrogen, as well as swelling;
• a decrease in the indicators of the release of gonadotropin.

In the case of poor physical activity, as well as in women with breast carcinoma, hypercalcemia may appear.

In addition, women may experience a decrease in voice timbre, an increase in the size of the clitoris, a violation of the menstrual cycle, the development of hirsutism, and hair loss.

Men sometimes experience the appearance of oligospermia, inflammation of the mammary glands, and in addition an increase in the size of the penis and the frequency of erections.

Overdose

With the abuse of Retabolil, its uncontrolled and prolonged use, the appearance of disorders affecting the endocrine system and NA can be observed.

Interactions with other drugs

Steroids are able to potentiate the activity of coumarin derivatives and anticoagulants.

It is required to very carefully combine the medication with hypoglycemic substances. It is recommended to reduce the amount of insulin.

Blood values and glucose tolerance should be monitored regularly.

Storage conditions

Retabolil must be stored in a place protected from the penetration of children and sunlight, with a temperature not exceeding 25 ° C.

When a sediment appears at the bottom of the drug ampoule (with the condition that the drug has not expired by this time), it is necessary to warm it up to dissolve it. For intramuscular injections, an exceptionally clear liquid can be used.

Shelf life

Retabolil can be used within a 5-year period from the date of manufacture of the therapeutic element.

Analogs

Analogues of drugs are the substances Fortabolin, Superbolan with Anabozan-Depot, and in addition Gormoretard with Nandrolone decanoate, Decanandrolin with Turinabol-Depot and Abolon. Also on the list are Eubolin with Deca-Durabolin, Nortestosterone decanoate and Decanabol.

Reviews

Retabolil receives mostly positive feedback from patients. When used in compliance with the selected dosages, the development of negative symptoms is not observed. Also among the precautions is the refusal of the prolonged administration of the medication (over 6 months).