Biocerulin

Biocerulin is a blood substitute, a protein fraction of blood plasma.

The element ceruloplasmin is a multifunctional enzyme that contains copper. It is a glycoprotein of the α-globulin fraction obtained from human donor plasma. [1]

The substance increases the stability of cell walls (antioxidant effect and slowing down of lipid peroxidation), is a participant in ion metabolism and immune processes, and also weakens poisoning and stimulates the development of hematopoiesis. [2]Helps to nonspecifically protect the body from negative external influences. [3]

Indications Biocerulin

It is used to weaken poisoning and maintain the processes of immunoreactivity during complex chemotherapy in people with oncology (this includes patients with hematological malignancies accompanied by moderate poisoning). In addition, it is used in such cases:

• performing preparation before operations (especially in weakened people - with poisoning, anemia or severe exhaustion);
• during the early postoperative stage (in the case of severe surgical blood loss, as well as complications of a purulent-septic nature);
• stimulation of hematopoietic processes;
• combined treatment in persons with osteomyelitis in the chronic or active phase.

Release form

The release of the medication is realized in the form of an injection liquid - inside ampoules or bottles with a capacity of 0.1 g. Inside the package - 5 bottles or 5 or 10 ampoules.

Dosing and administration

The medication is applied through a dropper, intravenously - at a rate of 30 drops per minute.

Before use, you need to dissolve the contents of the ampoule or bottle in 5% glucose or 0.9% NaCl (0.2 l). The size of a standard 1-fold portion is 0.06-0.1 g, administered daily or every other day (determined by the patient's condition). The therapeutic cycle includes 5 injection procedures. In total, 0.3-0.5 g of drugs is introduced for the course.

In oncology, during preparation before the operation, the medication is used every day or every other day in a portion of 0.5 mg / kg. The whole cycle lasts up to 10 injections (the patient's condition is taken into account). During the postoperative stage, the dosage is selected taking into account the blood loss (from a dose of 0.5 mg / kg, if it is small, to a dose of 1.5 mg / kg, if it is massive). You need to apply it daily for a period of 5-8 days.

During chemotherapy, 1 dose is equal to 1-1.5 mg / kg, and the treatment cycle consists of 10-14 procedures (3 injections per week).

In persons with hemoblastosis, a single dosage is 0.5-1 mg / kg; the entire therapeutic course includes 5-8 injections (daily, once a day).

In the case of the active phase of osteomyelitis, a single dosage is equal to 1 mg / kg. During the treatment course, 5 injections are administered daily or every other day.

If osteomyelitis is chronic, Biocerulin is prescribed in a 2 mg / kg portion with 2-3 times use, with a 1-2 day interval. Next, the medication is administered in the amount of 1 mg / kg, 3-7 times a day, every other day.

• Application for children

Prescription of drugs in pediatrics has not been studied, therefore it is not used for this category of patients.

Use Biocerulin during pregnancy

The use of Biocerulin in breastfeeding or pregnant patients has not been studied, which is why it is not used in this group of patients.

Contraindications

It is contraindicated to use the medicine with severe intolerance to substances of a protein nature.

Side effects Biocerulin

The use of the medication can cause such side signs: nausea, epidermal rash (urticaria), hot flashes, a short increase in temperature, allergy symptoms, chills and manifestations in the area of the injection. With such violations, the dosage or injection rate is reduced, or the medication is canceled.

Clinical tests show that usually negative reactions occur due to an increase in the rate of drug infusion. Low speed drip is often straightforward.

Interactions with other drugs

The medicine must not be mixed with other medicinal substances.

Use in combination with 5% glucose or high dosage corticosteroids increases the likelihood of diabetes.

Storage conditions

Biocerulin must be stored in a place protected from moisture and penetration of children. The temperature level is in the range of 2-8 ° C.

Shelf life

Biocerulin can be used for a 2-year term from the date of manufacture of the medicinal substance.

Analogs

The analogues of the drug are Tenziton, Albumin, Polyglyukin with Venofundin, Refortan with Khetasorb, and besides this, Gekodes, Reopoliglyukin and Hyperhaes.