Hexoral for purulent sore throat: effectiveness

Infectious-inflammatory diseases of the throat are always an indication for combined treatment, with the use of oral and external drugs. External agents, represented by antimicrobial and antiseptic solutions, play a special role in the therapeutic scheme. For example, the famous preparation of Hexoral for angina significantly increases the effectiveness of other medications taken internally. Thanks to Geksoral, the disease is cured faster.

Sprays from a sore throat with an antibiotic

To kill pathogenic bacteria in most microbial diseases, the use of antibiotics is required. Most patients with angina often ask the doctor to prescribe an antibiotic not only for internal use, but also for external use - for example, for irrigation or rinsing of patients with tonsils. Indeed, an integrated approach is necessary, and the impact on the focus of the inflammatory process must be comprehensive. However, here it is necessary to explain the situation correctly.

Antibiotics are a number of substances synthesized by special microorganisms, which, in turn, are capable of damagingly affecting other living cells - mostly prokaryotic and protozoans. To date, this is a vast group of drugs, each representative of which has its own spectrum of antibacterial effects and indications for use. The first known antibiotic was penicillin: since then almost a century has passed, and the number of antibiotics used in medicine is rapidly increasing.

Antibiotics are released in different dosage forms. These can be tablets, capsules, powder, ointments, creams and injectable solutions (or lyophilizate for the preparation of such a solution).

As for the  spray  or  aerosol, they are not antibiotics used as such, but antiseptic and antimicrobial substances - for example, hexiethidine, which belongs to a number of external antiseptics. Therefore, the phrase "spray with antibiotic" is not entirely correct.

Among the most famous hexaethidine-based sprays are Stopangin, Maxikold and Geksoral.

Indications Hexoral with angina

The main indications for the use of Geksoral are:

• angina (tonsillitis lateral cusp, Plauta-Vincent, catarrhal and purulent tonsillitis);
• inflammation of the gums, bleeding, pharyngitis;
• inflammation of the periodontal disease, stomatitis, inflammation of the tissues of the tongue;
• aphthous ulcerative processes;
• damage to the alveoli after tooth extraction;
• fungal lesions of the mouth and tonsils.

You can apply Geksoral before operations in the oral cavity, and after them, as well as to get rid of the fetid smell.

Hexoral for purulent sore throat

It is impossible to imagine the treatment of purulent sore throat without local procedures. Such procedures involve the use of drugs that contain antiseptics, essential oil, painkillers. But such treatment should always be supplemented by taking antibiotics and other auxiliary drugs - for example, immunostimulants, vitamins, anti-inflammatory drugs.

For the rinsing of the throat can be used as a universal means (furacilin, soda or saline solution, decoctions of plants), and specially designed for this preparation - such as Hexoral. Careful rinsing allows you to rinse tonsils from pus, wash the plaque, which consists of food particles, microbes, dead leukocytes, necrotic tissues.

You can use with purulent sore throats and candies: they are recommended to dissolve in the mouth after eating, alternating with rinses and / or irrigation with the same Hexoral. The use of aerosol formulations is convenient: the procedure can be carried out even when outside the home. The smallest particles of the spray penetrate deep into the throat, providing therapeutic effect in the most inaccessible areas.

But the use of the drug in viral sore throats is not always justified: the antiseptic destroys only the bacterial and fungal flora, and does not affect the virus infection. Geksoral for herpes sore throat can be prescribed only for the prevention of secondary microbial infection, as well as to combat it. In addition, the presence of an anesthetic component in the lozenges of Geksoral allows them to be used as an analgesic against pain in the throat, including with herpes sore throat.

[1],

Release form

Hexoral can be used to treat sore throats, using several dosage forms. Such forms are different in composition, have different pharmacokinetic properties, but they have a common pharmacodynamics, since they are based on one active ingredient.

• Hexoral spray with angina can be used in adults or in children, starting at the age of three. Advantages of hexoral aerosol are its universality and ease of use: the therapeutic solution effectively irrigates the affected areas, penetrating even in hard-to-reach places. Spray is used for any kind of bacterial sore throat: with purulent, lacunar, follicular form of the disease. The active ingredient is hexethidine.
• A solution of Hexoral is used for rinsing the oral cavity and the area of the tonsils. The basis of the drug is hexethidine and ethanol. It does not need to be diluted: it is ready for use.
• Lozenges for resorption. Hexoral is not only a medicine, but also a delicious treat, which children gladly accept. Lollipops can be given to a child from almost any age: the main thing is for the baby to keep and dissolve the drug in the mouth, not swallowing it and inhaling (not to choke). In addition to the basic active ingredient in the lozenges, there is an anesthetic component of benzocaine, antiseptic chlorhexidine and other components, including flavor and flavor additives.

[2]

Pharmacodynamics

The active ingredient of Hexoral is Hexetidine - a substance with a rapid and prolonged antiseptic effect. The drug has an antimicrobial and antifungal effect in relation to the vast spectrum of pathogens that can cause angina. Wound healing, hemostatic and analgesic abilities of Hexetidine are also known.

The antimicrobial effect is manifested in vivo / in vitro relative to gram (+) and gram (-) microbes, as well as fungal infection (including yeast fungi).

When using Geksoral for angina, plaque may appear on the teeth and mucous membranes: such a plaque is the residual concentrations of Hexetidine. Testing using a labeled substance showed that the drug is able to be detected in the tissues of the oral cavity for 8-10 hours after a single application. In some cases, the substance was found in the tissues even after 65 hours after the last application.

Pharmacokinetics

Clear clinical information on the kinetic properties of the drug there. It is known that Geksoral has an external action, so its absorption through mucous tissues is negligible.

The close relationship of the active ingredient with proteins and polymers determines its binding to microbial cells, and also affects its effect of residual concentration. Antimicrobial action can be detected approximately 10-14 hours after application.

Absorption of the drug at its local application was not investigated.

Kinetic properties Hexoral for use in patients with impaired renal and / or liver function has not been studied.

Dosing and administration

• Solution Geksoral for angina is used to rinse the throat. Such rinses should be repeated two or three times a day, after a meal. The duration of one rinse is about half a minute. The amount of solution for one rinse is about 15 ml. Rinse gently to avoid accidental ingestion of liquids. With purulent sore throat, you can also lubricate this solution with inflamed tonsils.
• With angina, spray Hexoral sprayed deep into the throat, well watering the surface of the tonsils. For the treatment of the child, the spraying is continued for one second, repeated up to 2 times a day, after eating. In adults, spraying can last 2 seconds, and the treatment can be repeated up to four times a day (after meals and always before bedtime).
• Candies Geksoral do not swallow and do not gnaw, but slowly dissolve in the mouth. To ease the condition with angina children should take 4 candies a day. The daily dosage for adults is one lollipop every two or three hours.

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Application for children

Children suffer from angina more often than adults, and this is considered a common occurrence: after all, the children's immune system is formed over a period of 12-14 years. For all this time the body must learn to resist the infection. In young children, the most severe variant of the disease is especially often diagnosed - purulent angina. Therefore, treatment should be versatile in order to accelerate the onset of relief, because the baby is very painful to swallow, his appetite is gone, the temperature rises.

What kind of medicine to choose to help your child as efficiently and safely as possible?

The medicine from angina should quickly fight with inflammation, destroy pathogenic microbes, and at the same time should act gently, not aggressively, so as not to break the shaky immunobiological balance in the child's body. Hexoral is represented by several dosage forms recommended for prescription in pediatrics.

If the baby is already three years old, then to treatment of angina, you can connect Hexoral in the form of a rinse liquid. It does not matter that the child does not know how to gargle independently: the tonsils can simply be lubricated with a solution with a cotton swab or a bandage wound on a finger. From the same age, it is permitted to use the aerosol form of the medicament.

Aerosols for children from angina (Hexoral including) act quickly and practically do not enter the systemic circulation, so the risk of systemic side effects can be called insignificant. But all the same it is necessary to watch, that the kid necessarily held a breath at the moment of injection of the means that casually did not swallow a solution.

Lollipops for the oral cavity are very popular with older children. They are allowed to offer the baby from the age of four, and some species - for example, Geksoral Extra - only from the age of twelve. How to determine that a child can already take candies? If he is able to keep the lozenges in his mouth until it is completely resorbed, without swallowing the drug and chewing on it, then he can already be offered them without fear.

Use Hexoral with angina during pregnancy

Because of the lack of information on the kinetic properties of the drugs, hexoral should not be used without special indication when they are pregnant. It is not known for certain whether Hexetidine and the products of its metabolism enter breast milk, so it is better to refrain from using Hexoral in the lactation period.

A small amount of the drug can enter the systemic circulation. Most experts believe that the negative effect of the drug on fetal development or on the health of an infant is unlikely. Nevertheless, without special need, it is better not to use gexoral in case of pregnant women and nursing patients.

Contraindications

Hexoral for angina is better replaced by another drug if there are such contraindications to its use:

• excessive sensitivity to the active ingredient Hexetidine, or to the auxiliary components of the drug (essential oils, levomenthol, azorubin, benzocaine, etc.);
• atrophic processes in mucous tissues.

The possibility of using Hexoral for the treatment of angina in an infant should be discussed with the pediatrician. Many experts, given the insufficient amount of information on the pharmacological properties of the drug, do not advise prescribing it to children up to the age of three.

[3], [4]

Side effects Hexoral with angina

Even such a seemingly harmless drug, like Hexoral, with angina can cause the following side effects:

• hypersensitive reactions (skin rash, swelling, laryngo or bronchospasm);
• malfunctioning of taste buds;
• cough, difficulty breathing;
• thirst, difficulty swallowing, dryness of mucous membranes in the mouth, nausea;
• allergic dermatitis;
• local signs (transient changes in color of mucous tissues and teeth, burning, numbness in the mouth, the appearance of rashes and sores);
• allergic reaction (allergies are particularly susceptible to patients sensitive to the action of acetylsalicylic acid).

Most of the side symptoms are transitory and pass after the end of treatment with angina Hexoral.

[5], [6], [7]

Overdose

If a large amount of Hexoral solution is accidentally swallowed, alcohol poisoning may occur, since the preparation contains ethanol.

Concentration content of the active ingredient of Hexetidine in the preparations is not dangerous and is not toxic (provided the medicament is used for its intended use).

At the moment, there has not been a single case of excess dosage of Hexoral with the development of hypersensitivity reactions.

The general principles of treatment of overdose are as follows:

• use of symptomatic drugs;
• gastric lavage (expediently within two hours after ingestion of the drug);
• use of a large number of clean drinking water or other liquid.

Interactions with other drugs

There were no specific and clinically significant interactions of other drugs with Geksoral. However, experts do not advise the use of several antiseptic solutions simultaneously. This can lead to unpredictable reactions, and also negatively affect the condition and quality of mucosal repair.

It is reported that the active ingredient Hexetidine becomes inactive under the influence of alkaline liquids and solutions, therefore such combinations should be avoided.

[9], [10], [11]

Storage conditions

Preparations Geksoral (aerosol, solution, lozenges) is recommended to keep in a temperature mode, not exceeding + 30 ° C. Optimum, if the medicine will be stored in factory packaging, inaccessible to ultraviolet rays and for children. You can not freeze the medicine.

Solution Geksoral should not be used if more than six months have passed since the bottle was opened.

Shelf life

Preparations of Geksoral can be stored for up to two years (provided that the medicines have not been opened and the packaging has not been damaged).

Hexoral in angina: are there analogues?

The complete analogues of the medicament Hexoral, which can also be used in angina, are:

• Spray Hexosept 0.2%;
• solution of Stomatidin 0.1% for rinsing;
• solution Stomolik 0.1% for rinsing.

These drugs are represented by the same active ingredient that is also present in Hexor alle - it is about Hexetidine.

Also, Geksoral can be replaced by other external means, the action of which is maximized to it.

• Propohalum with angina may well replace Hexoral. This drug is also available in the form of an aerosol, but the active ingredient is not Hexetidine, and propolis is a well-known beekeeping product. In addition to strong antimicrobial action, Proposol promotes strengthening of local immunity, improves metabolic processes, accelerates the regeneration of tissues. And another special property of this drug is its pronounced antioxidant activity: propolis protects tissues from the effects of free radicals and peroxide compounds. However, it should be borne in mind that Propofol, like other bee products, can cause allergic reactions. Therefore, for the first time, use this medication with caution, after a preliminary allergy test.
• Miramistin with angina is used not less often than Geksoral: both of these drugs have an extensive antimicrobial spectrum of activity and show pronounced efficacy in many infectious diseases. Miramistin activates the immune non-specific reaction, stimulates immune cells, accelerates the healing of inflamed tissues. The solution for angina can be used to lubricate mucous membranes, or for rinsing - 4-6 times a day.
• Tantum Verde in angina plays the role of analgesic and blocker of the inflammatory process. This drug belongs to nonsteroidal anti-inflammatory drugs, its action is based on the effect of the active ingredient benzidamine hydrochloride. Tantum Verde is presented in pharmacies with different dosage forms, including resorption tablets, spray, rinse solution. This drug is well suited to supplement the main treatment of angina, including purulent form.

Patient Reviews

For today in any drugstore it is possible to find a huge choice of every possible preparations, capable to struggle with pathogenic microorganisms. In what cases do patients choose Geoxoral? If a person feels unpleasant burning sensation, soreness in the throat, if it becomes difficult to swallow, or other uncomfortable symptoms appear in the pharyngeal zone, this often indicates the development of diseases such as pharyngitis (infection of the pharynx), laryngitis (inflammation in the larynx) , tonsillitis (inflammation of the tonsils, tonsillitis). Judging by the reviews, hexoral for angina is one of the best options for patients of any age category. The drug quickly relieves acute pain. However, it must be remembered that the treatment of the inflammatory process should be carried out not only with topical preparations, but also with systemic medicines with anti-inflammatory and antimicrobial effect. Therefore, the general treatment regimen should be prescribed only by a doctor-otolaryngologist, pediatrician or therapist.