Papaver

Papazol is a vasodilating antispasmodic drug.

[1], [2]

Indications of the pasage

Applies to such violations:

• an unstable increase in blood pressure;
• spasms developing in the area of the peritoneal organs;
• paralysis in the peripheral facial nerve;
• spasms affecting the cerebrospinal vessels and arteries.

Prescribing the drug can also with residual symptoms after a disease such as polio.

[3], [4], [5]

Release form

The medicine is released in tablets, in quantities of 10, 20, 25, 30, and 40, 50 and 60 pieces inside the blisters.

The form of the preparation Papazol UBF is produced in packs, in the amount of 10, 20, as well as 30 and 50 pieces.

[6], [7]

Pharmacodynamics

The drug acts on the body with the help of 2 active elements - papaverine with bendazole. The first weakens the vascular resistance and reduces the values of AD - by blocking the enzymes PDE and CK within the vessels. The number of Ca within the cells decreases, and the cyclic AMP accumulates, which results in a vasodilator effect of the drug. Also, papaverine has an antispasmodic effect on the gastrointestinal tract, ZHVP and urinary ducts.

Bendazole has a direct effect on the imidazole ends of the smooth muscles of the vascular walls. This allows you to remove spasms, reduce blood pressure and reduce the intracellular amount of Ca. In addition, this element stimulates spinal activity and, in case of prolonged use, plays the role of immunomodulator. Activation of the binding of nucleic acids and protein, and the production of antibodies with phagocytosis also occur.

The drug has antispasmodic, vasodilating and vasodilator properties. When used in large portions has a weak sedative effect.

Papazol reduces the level of pressure by reducing the resistance of the vascular walls.

[8], [9], [10], [11], [12], [13], [14]

Dosing and administration

Tablets are taken orally. Often the size of the daily portion is 2-6 tablets, which must be taken for 2-3 uses.

[24], [25], [26], [27]

Use of the pasage during pregnancy

At the moment, there is too little data on the possibility of using drugs during pregnancy. Therefore, he is appointed cautiously and only under the supervision of a doctor.

It should be noted that pregnant women who used Pape to reduce blood pressure were happy with the result.

Contraindications

Among the contraindications:

• the presence of an allergic reaction to the drug;
• epilepsy and suppression of respiratory organs;
• AV-conduction disorders;
• renal and hepatic pathologies;
• presence of an IBT or hypothyroidism;
• weakening of the processes of intestinal peristalsis, and in addition certain diseases of the prostate.

Caution is required when using the medication during lactation.

[15], [16], [17], [18]

Side effects of the pasage

The use of medication can lead to the appearance of hyperhidrosis, nausea, allergy symptoms, and in addition to constipation and disorders of the function of the heart muscle.

[19], [20], [21], [22], [23]

Overdose

When poisoning can manifest symptoms of dyspepsia, as well as increase the severity of adverse symptoms.

Symptomatic measures are taken to correct the violations.

Interactions with other drugs

It is forbidden to combine with adsorbents, but also with drugs that have astringent properties, as well as enveloping properties in the gastrointestinal tract.

The effect of the drug is potentiated when combined with tricyclics, reserpine, antispasmodics, sedative drugs, as well as diuretics and novocainamide.

Papazol weakens the effectiveness of proserin, levodopa and anticholinesterase drugs.

The toxic effect of the medicine on the liver when used together with nitrofurantoin is potentiated.

[28], [29], [30], [31]

Storage conditions

The papal must be kept in a place that is closed from penetration of sunlight. The temperature should not exceed 30 ° C.

[32], [33], [34], [35]

Shelf life

Papazol is allowed to be used for 5 years after the release of the drug.

[36], [37]

Application for children

Prescribing the drug to children under 12 years of age is prohibited.

[38],

Analogues

Analogues of the drug are Duzofarm, Papazol-LHFZ and Papazol-Darnitsa, and besides this, Dibasol, Vinoksim MB and Enelbin 100 retard.

[39], [40], [41],

Reviews

Papazol receives a lot of positive feedback about its drug effect. It is usually used for problems with pressure. At high indices of blood pressure, if it is taken for a long time (1-5 years) and for medical reasons, the medicine acts very effectively.

But in this case, in the case of elderly patients with rapid and strongly pronounced jumps in blood pressure, the drug may not always be effective.