Medical expert of the article
New publications
Preparations
Meverine
Last reviewed: 23.04.2024
All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
Indications of the meverina
It is used for the following procedures:
- symptomatic measures to remove abdominal cramps and pain, and in addition to this feeling of discomfort, as well as disorders that develop with a diagnosed IBS;
- elimination of spasms in the gastrointestinal tract, having a secondary nature - due to diseases of ZHVP, liver, pancreas, and in addition to this intestine.
Release form
Release of the medicine occurs in capsules, in the amount of 30 pieces inside the pack.
Pharmacodynamics
Meverin is a selective myotropic antispasmodic having a pronounced effect on smooth muscle in the gastrointestinal tract. The substance mebeverin can eliminate muscle spasms inside the gastrointestinal tract, at the same time without affecting the healthy function of intestinal peristalsis.
The medication is prescribed for people suffering from digestive disorders, in which painful sensations of a spastic nature are noted, and in addition to treatment of organic diseases of the digestive organs, with the development of spasms of the secondary type in the gastrointestinal tract.
Inside the smooth muscle cells, the mebeverin, administered in a dose, blocks the membranes of the Na channels, and at the same time prevents the passage of sodium ions into the cells, and in addition spasms in the smooth muscle region of the internal organs.
If we compare it with anticholinergic drugs, the drug does not affect M-cholinergic receptors and does not cause side effects characteristic of this category of spasmolytics (such as visual disturbances, delay in the process of urination and dryness of the oral mucosa). This allows you to use it with an enlarged prostate and glaucoma. Along with this, the use of drugs does not lead to the formation of intestinal hypotension, which has a reflex origin.
Pharmacokinetics
After taking the capsule inside, the medicine goes through the process of presystemic hydrolysis. Inside the blood plasma, the substance is not recorded. Metabolism is carried out inside the liver, resulting in the formation of mebeverin alcohol along with veratric acid.
Most of the drug is excreted through the kidneys - in the form of dimethylcarboxylic, as well as carboxylic acids. The smaller part stands out with bile.
Long-term release of the active element from the capsules still does not cause its significant cumulation.
Dosing and administration
The drug should be taken in a dose of 0.2 g (the volume of the first capsule), twice in 24 hours. It is recommended to take the drug 20 minutes before eating.
Capsules should be swallowed whole, washed down with plain water. The duration of the treatment course is selected taking into account the severity of the disease and symptoms.
[10]
Use of the meverina during pregnancy
Use Meverin in lactation or pregnancy is only necessary for the indications, as well as under the supervision of the treating doctor.
Contraindications
The main contraindications:
- intestinal obstruction, paralytic;
- the presence of hypersensitivity to mebeverine or other elements of the drug.
Overdose
At a poisoning with mebeverinum often quickly eliminated attributes of potentiation of excitability of a central nervous system.
To remove the disorders, you should perform gastric lavage, and then carry out symptomatic activities (if they are needed).
Storage conditions
Meverin is contained in standard for medicines conditions. Temperature marks are within 15-25 ° C.
[11]
Shelf life
Meverin can be used for 2 years from the date of manufacture of the therapeutic agent.
Application for children
The appointment of a medication to people under the age of 18 is prohibited.
Analogues
The analogues of the drug are Tribudate preparations with Tribux, and in addition Trigan and Trimspa.
Reviews
Meweryn usually receives positive reviews. The medicine copes well with the manifestations of IBS, and in addition to signs of spasms in the gastrointestinal tract, which have a secondary nature. Has no effect on healthy intestinal function and almost does not cause negative manifestations.
But it must be taken into account that this medication is only able to weaken the course of the disease only for a while and it can not be considered a preparation of the main therapy. Also it should be remembered that only a gastroenterologist can prescribe drugs.
Attention!
To simplify the perception of information, this instruction for use of the drug "Meverine" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.