Macmirror

One of the most effective antimicrobial and disinfecting drugs that are used, including in gynecology, is considered to be Macmirror.

[1], [2], [3]

Indications of the macmiorora

The drug Macmorore can be used to treat:

• vulvovaginal infectious pathologies, provoked by pathogenic microbes, fungi, chlamydia, Trichomonas, etc .;
• urinary tract diseases (inflammatory processes in the bladder, urethra, kidneys);
• intestinal lambliasis and amoebiasis.

[4], [5], [6]

Release form

Produced Macmirror in the form of convex tablets, covered with a soluble protective coating.

The active ingredient of the medicament is a nifuratel, the content of which in one tablet is 0.2 g.

Tablets are packed in blister plates of 10 pieces each.

The cardboard box contains two blister plates.

[7], [8]

Pharmacodynamics

The active substance of the drug Macmiore is a nitrofuran drug nifuratel.

Studies have confirmed the extensive antimicrobial effect of the nifuratel, which is especially evident in infectious diseases of the urinary and reproductive system. The principle of the drug's action has not been thoroughly studied. Nevertheless, it is determined that McMiore metabolic pathway influences the enzymes that promote the development and growth of bacteria. Similarly, the drug acts on the Trichomonas.

Macmirror can be used as an antimicrobial agent for exposure to gram (+) and gram (-) aerobes and anaerobes. The lowest effective dosage can be from 2.5 to 5 μg per ml.

Macmirror has a powerful oppressive effect on chlamydia and a weaker one on ureaplasma and mycoplasma. Antifungal effect is less noticeable if you compare the drug with ketoconazole or flutrimazole.

The extensive antimicrobial effect of MacMiore allows it to be used in any infection of the genital and urinary organs. At the same time, the nafuratel does not inhibit the lactobacilli entering into the natural composition of the qualitative bacterial flora: due to this, recovery is accelerated in vaginal inflammatory pathologies, and re-reinfection is also excluded.

A good effect shows the drug in the treatment of patients with intestinal diseases - amoebiasis or giardiasis. There is also information about the significant antiprotozoal ability of MacMyor.

Macmirror does not lead to the development of cross-resistance of bacteria to other antimicrobial drugs.

Pharmacokinetics

After oral administration, 0.2 g of Macmiore is rapidly digested in the digestive tract. The level of the active ingredient in the blood plasma 120 minutes after the administration was about 9.48 μg per ml.

The active substance is quickly distributed across all tissues in the body. The half-life can be about 2.75 hours.

About half of a percent of the active ingredient is excreted with the urinary fluid in an unchanged state. The rest leaves the body in the form of residual exchange products.

Nifuratel - the active ingredient - was not detected in intrahepatic circulation.

Dosing and administration

• Infectious pathology of genital organs.

Adults are recommended to appoint 1 tablet. McMiore three times a day after a meal, for a week. It is desirable to conduct simultaneous treatment of the patient and her sexual partner. Additionally, intravaginal capsules and / or MacMyor cream may be used.

In some cases, it is possible to administer 4 tablets daily. Sexual contacts during the therapeutic course should be stopped.

In childhood, starting from 10 years, McMirror is prescribed in the amount of 10 mg per kilogram of body weight daily, dividing the dosage into two doses. The duration of the course in this case will be about 10 days.

• Infectious diseases of the urinary system.

Adults appoint from three to six tablets Makmiror daily (0.2-0.4 g per day) after eating. The duration of therapy is about 7-14 days.

In childhood, from the age of six, Macmirror can be prescribed in amounts of 10 to 20 mg per kilogram of body weight per day (in two divided doses). The course of therapy is 7-14 days.

If necessary, treatment can be more prolonged.

• Amoebiasis of the intestine.

Adults are assigned 2 tablets Macmirror three times a day, after meals, for ten days.

In childhood, from the age of six, it is appropriate to appoint a daily dosage of 30 mg per kilogram of body weight. The total amount of the drug is divided into three doses. The course of therapy - 10 days.

• Giardiasis of the intestine.

Adults take 2 tablets Macmirror up to 3 times a day, after eating. Duration of admission is one week.

Children from the age of six take the medicine at a rate of 30 mg per kilogram of weight, dividing the dosage into two doses. Duration of the course is one week.

[11]

Use of the macmiorora during pregnancy

Features of the application of makmiror for the treatment of pregnant and lactating women read in this article.

Contraindications

Do not use Macmirror:

• with hypersensitivity to the medicine;
• with severe kidney pathologies;
• with neuropathy;
• with a deficiency of glucose-6-phosphate dehydrogenase;
• children under the age of six;
• women during the entire period of gestation and feeding the baby.

Side effects of the macmiorora

Among the few side effects most often can occur:

• food disorders;
• attacks of nausea, diarrhea, a feeling of bitterness in the mouth;
• vomiting;
• skin problems, itching hives;
• peripheral neuropathies.

[9], [10]

Overdose

At the moment, there was not a single patient with an overdose of Macmiore.

Interactions with other drugs

Clinically significant interactions of the therapeutic agent Macmiore with other medications is not defined.

It is known that the simultaneous use of alcohol can provoke the development of disulfiramoid syndrome, which is manifested by pain in the chest, redness of the skin, palpitations, nausea, reflex cough.

[12]

Storage conditions

Makmiror recommended to store in rooms with a temperature regime of +18 to +25 ° C, away from children's access. The storage area should be dry and at a distance from sources of bright light and heat.

[13]

Shelf life

Macmirror can be stored for up to 5 years.