Tablets from a sore throat

In the treatment of throat diseases - for the removal of pain - a large number of pharmaceutical preparations in the form of solutions for topical application, sprays, troches, as well as special tablets for resorption. Many such pills from sore throats help not only to remove unpleasant symptoms, but also to stop the development of the inflammatory process that caused them.

Indications for the use of tablets from pain in the throat

The main indications for the use of tablets from sore throat are inflammatory diseases of the throat and larynx of infectious etiology. These include acute pharyngitis, acute laryngitis, tonsillitis, acute inflammation of the tonsils (lacunar and fibrinous angina), tracheitis.

Medicines in the form of tablets for resorption are also used in the treatment of microbial and bacterial lesions of the oral cavity (stomatitis, thrush, etc.).

Pharmacodynamics of tablets from sore throat

The mechanism of antibacterial action of tablets against sore throat is based on their activity against pathogenic microorganisms - gram-positive and gram-negative (Streptococcus haemolyticus, Streptococcus viridans, Staphylococcus aureus, Pseudomonas aeruginosa, Haemophilus influenzae, Branhamella catarrhalis, Candida albicans, etc.). Due to their ability to interact with lipids of cell membranes of microorganisms and to violate their integrity, the active substances of these drugs lead to the death of bacterial cells.

So, Grammidine contains antibiotic gramicidin, and for the removal of pain in the throat - lidocaine hydrochloride, eucalyptus oil and menthol. Although eucalyptus oil has anti-inflammatory properties, but menthol serves as a "distracting" remedy: it alleviates pain by stimulating the cold mucosal receptors.

The streptsils resorption tablets contain an antibiotic for topical use of amylmetacresol, as well as the same local anesthetic as lidocaine hydrochloride. Neo-angin has an antiseptic effect due to such components as dichlobenzyl alcohol and amylmetacresol. A analgesic effect has a levomenthol (acts in the same way as menthol). Active substance ammonium monohydrate, being a bacteriostatic agent of topical application, provides the therapeutic effect of Tharyngept.

With inflammation in diseases of the throat, chlorhexidine hydrochloride, a broad-spectrum antiseptic, is also active, an active component of the tablets from the pain in the throat of Hexoral. A decrease in pain sensitivity, i.e., a blockade in the appearance and carrying out of nerve signals, is performed by local anesthetic benzocaine (4-aminobenzoic acid ethyl ester): it rapidly penetrates the cell membranes, changes the balance of sodium and potassium ions in the peripheral pain receptors of the mucous throat, the passage of pain impulse.

Tablets for resorption from pain in the throat Strepfen have a non-steroidal anti-inflammatory agent flurbiprofen - a derivative of propionic acid. This substance delays the synthesis of the enzyme cyclooxygenase and the main neurotransmitters of pain (prostaglandins), removing inflammation of the mucous membrane of the upper respiratory tract and arresting pain.

Pharmacokinetics of tablets from sore throat

Due to low systemic absorption, there is no data on the pharmacokinetics of many tablets from sore throat. But there are some data on the biochemical transformation of these drugs.

For example, benzocaine contained in tablets Hexoral, is cleaved by the enzyme esterase in blood plasma and liver to paraminobenzoic acid and ethyl alcohol. In the course of their metabolism, chemical compounds are obtained, which are excreted from the body by the kidneys.

Flurbiprofen, which is contained in Strepfen tablets, comes with saliva in the digestive tract, where its rapid absorption occurs. On average, after 35 minutes, the concentration of the drug in the blood plasma reaches its maximum level. In this case, almost 100% is associated with plasma proteins. This drug then passes through all the metabolic stages (in the liver) and is excreted in the urine.

Tablets for resorption from pain in the throat

These drugs have become very popular both because of their ease of use, and because of their effectiveness. In almost half of the cases, the cause of sore throat is an infection, so all the pain relievers for the throat relate to the pharmacological group of antiseptics and disinfectants. First of all, they have antiviral, antimicrobial and anti-inflammatory effects. And already in the second turn relieve the pain.

Take note of the main names of tablets from the pain in the throat: Strepsils, Grammidine, Hexoral, Neo-angin, Pharyngosept, Strepfen. And now consider the features of their use, contraindications and dosage.

Dosing and Administration

Tablets from the pain in the throat of Strepsils are used in the treatment of adults and children older than 5 years. It is necessary to dissolve the tablet every 2.5 hours. But per day you can use no more than 8 tablets.

Dosage and administration of Gramidine: for adults and children over 12 years of age, the drug is prescribed 2 tablets (first one tablet dissolves, immediately on it - the second one). After this, one should at least an hour and a half eat nothing and do not drink. This procedure is carried out 4 times a day for 5 days. Children under 12 years of age need to resolve only one tablet. The course of treatment is 5-6 days.

Tharyngept should be dissolved within half an hour after eating: adults - 4-5 tablets a day, children 3-7 years - 3 tablets a day. Duration of use - 3-4 days. Neo-angin pills are prescribed for adults and children over 6 years of age: dissolve one tablet every three hours. The maximum dose is no more than 6 tablets per day.

The tablets for resorption from a pain in a throat Strepfen to children till 12 years do not apply. Adults (and children over 12 years of age) are recommended to dissolve one tablet with severe pain in the throat and inflammation of the mucosa. The maximum daily dose should not exceed 5 tablets, and the duration of use is three days. And, dissolving the Strepfen tablet, you should not keep it in one place, but you need to move around the entire oral cavity.

As indicated in the instructions of most of the tablets from sore throat, an overdose of these medicines is unlikely, since the level of their systemic absorption is very low. Exceeding the dosage prescribed by the doctor for Neo-angin can cause nausea, vomiting, reddening of the mucous membrane of the mouth and throat, as well as a feeling of discomfort in the stomach.

[6], [7]

Using pills from sore throats during pregnancy

The use of tablets against pain in the throat during pregnancy and during breastfeeding may use the drug according to the indications. The use of Gramidine during pregnancy involves increased caution and is permissible solely on the prescription of a physician.

The use of Strepfen during pregnancy is contraindicated. But Neo-angin pregnant can be used, but only for the doctor's prescription and for a short time.

Contraindications to the use of tablets against sore throat

Contraindications to the use of tablets from the pain in the throat Strepsils - hypersensitivity to the components of the drug and children under five. And Neo-angin can not be given to children under six years old.

Gramidine is contraindicated in women during lactation. Hexoral should not be used in cases of hypersensitivity to the substances in the composition, as well as in the presence of ulcers and erosions in the mouth or throat, with a lower concentration of cholinesterase in the blood plasma, as well as children under the age of four.

Strepfen is contraindicated in gastric ulcer in the phase of exacerbation, with bronchial asthma and runny nose (in parallel with the use of aspirin or other non-steroidal anti-inflammatory drugs).

[1], [2], [3], [4], [5]

Side effects of tablets from sore throat

The apparent side effects of the pills from sore throat are mostly absent, although sometimes they appear as minor allergic reactions. However, there are among these drugs and such, the use of which is fraught with undesirable side effects.

For example, in Geksoral (with prolonged use), the possible side effect is expressed in temporary numbness of the tongue, discoloration of the tongue and tooth enamel, as well as taste disturbance. In addition, benzocaine in the composition of this drug in children can cause an increase in the content of methemoglobin in the blood, which is manifested by such symptoms as cyanosis, hypoxia and tachycardia.

Tablets Neo-angina is usually well tolerated, but in isolated cases skin allergic reactions are possible. And for the Strepfen throat pills, the possible side effects are similar to those that all non-steroidal anti-inflammatory drugs can cause: headache, dizziness, skin rash, nausea, vomiting, heartburn, diarrhea, stomach pains, increased blood pressure, tachycardia and swelling.

Interactions of tablets against pain in the throat with other drugs

Tablets from the pain in the throat of Hexoral - due to benzocaine - reduce the antibacterial activity of sulfonamides and salicylates. And when Strepfen is used, the therapeutic effect of sulphinpyrazone and probenecid is reduced, which is used to reduce urate in the body in the presence of gouty deposits. Also, the therapeutic effect of glucocorticoids, estrogens, hypotensive drugs and diuretics is reduced. On the other hand, Strepfen is able to enhance the effect of anticoagulant drugs, which creates a threat of bleeding.

Conditions for storing tablets from sore throat

All tablets for resorption from pain in the throat should be stored in a dry place inaccessible to children; the optimum storage temperature is not higher than + 25 ° C.

The indicated shelf life of most tablets from sore throat is two years.

[8], [9], [10]