Zalox

The drug Zabolc applies to antidepressants with an active acting substance of sertralin, which is a chemical compound, which inhibits the reverse return of serotonin in neurons. This effective medical recruitment of the Canadian Corporation Farmasains Inc is widely used by modern psychiatrists.

Indications Zalox

Zadolsk was released by the manufacturer as a strong remedy that warns or boughts depressive states from patients. Hence the corresponding indications for the use of Zamols:

• Depressive psychosis, accompanied by a sense of anxiety.
• Manic manifestations of psyche disorder.
• The preventive use of an antidepressant warning the renewal of the disease.
• Treatment of obsessive conditions, obsessive-compulsive disorders.
• Agorathobia is a panic fear of open spaces.
• Post-traumatic stress disorders.
• Prevention of depressive relapses.
• Other manifestations of psychoses.

[1]

Release form

The drug is produced in a single form. The form of release of the drug is the capsules of white powder coated with a gelatin shell.

Pharmacodynamics

The mechanism on which the entire pharmacodynamics of Zabols is tied is that the dominant substance of the sertralin effectively slows down the ability of other chemical compounds to bind and derive serotonin from neurons, while dopamine and norepinephrine are not given such active exposure. Blocking of return transportation of serotonin, due to the active properties of a sertralin, occurs in platelets.

Reception of the blockage, as most antidepressants, leads to the suppression of the activity of the brain receptors (serotonin and norepinephrine). As clinical studies have shown, the chemical substance does not have radical points of contact with other receptors (such as histaminergic, cholinergic, dopaminergic, serotonergic, etc.)

Conducting controlled studies using a placebo showed that Zablo, with its active substance, does not show sedative properties. He is inert to influence the patient’s psychomotor.

Pharmacokinetics

The suction abilities of cermeraebrin can be called quite average. If the course of treatment of this drug provides for a long period of time, while the patient takes orally 200 mg of per diem, then the maximum amount of the substance in blood plasma (which will be 0.19 μg/ml) will be reached 4.5 - 8.4 hours after the drug entering the body.

Long-term is the half-life of this substance from the body - from 22 to 36 hours, depending on the individual characteristics of the patient’s body and his concomitant diseases. Due to the long period of half-life, the monitoring showed a double accumulation of the drug, which allows us to achieve equilibrium concentrations observed after one week of administration, while the patient is administered once a day.

Pharmacokinetics Zamols, falling into a numerical gap from 50 to 200 mg, largely depends on the dosage of the drug. The large percentage component of the sulfur is absorbed into the liver, degenerating into the derivative of N-demetilization. Subsequently, sertralin, its metabolites, having low pharmacological activity, are excreted from the patient’s body in equal amounts with fecal masses and through kidneys in urine. At the same time, the sertralin itself (unchanged) is excreted in a small amount, since about 98% of it with the protein component of blood plasma. To date, there are no reliable facts of collaboration of Zabols and from other drugs that have similar highly active ability to bind proteins.

Pharmacokinetics Zadloks on the floor and age qualification does not depend.

Dosing and administration

It must be clearly understood that the drug Zalkus must be taken only by prescription of the doctor and in strictly agreed dosages. As a rule, adults and children over the age of 13 years, the starting daily dose in the treatment of depressive conditions is prescribed in the amount of 50 mg. In case of nervous disorders characterized by panic symptoms, the starting daily dose is attributed in the amount of 25 mg, and, after a week of administration, the dosage is raised to 50 mg per day. You should not increase the amount of the drug taken independently.

If the improvement does not occur in the process of treatment, the attending physician can increase the dosage of the drug Zalkos, but this amount should not exceed 200 mg of per diem. It should also be borne in mind that the maximum concentration of sertralin, based on the pharmacokinetics of the drug, accumulates in blood plasma after the beginning of the intake.

Taking the medicine should not be canceled, even if there is no rapid improvement in health. This can take up to four weeks (about a month).

Method of use and dose: they suggest the introduction of Zabols as orally once during the day (either in the morning or in the evening). The capsule of the medicine must be swallowed by drinking with a certain amount of water. It is necessary to swallow the capsule - without chewing.

To cancel the intake of the drug Zalks in the right only the attending physician. The duration of taking the drug can reach several months. If for some reason one trick was missed, you should not shift the next technique anywhere (the medicine must be administered in the time set by the schedule) and take a double dosage.

If an overdose of the backlog occurred (accidentally or intends), you need to urgently contact the doctor, even if the patient feels quite well.

With prolonged use of the drug, the therapeutic dosage must be kept on an indicator of the minimum effective dose. In this case, the patient’s condition should be constantly controlled by a doctor, so that if necessary it is possible to adjust the dosage. In cases where the patient’s history is burdened with impaired liver function, the medical supplement must be prescribed carefully, the dosage should be reduced. If the pathology concerns the kidneys, due to the slight allocation of the sealin through them, there is no need to change the dosage.

Use Zalox during pregnancy

If a woman already knows about her pregnancy or plans to get pregnant in the near future, she must definitely notify her doctor about it. Due to the fact that a lot of experience in which the use of Zabolc during pregnancy would be recorded and analyzed, no, the use of this drug during the period when a woman plans to become a mother is not recommended. An exception may be cases of a serious clinical state of the patient, when the expected effect of Zabols is significantly significant for the health of a woman than the alleged harm to her and her unborn child.

If the patient is in reproductive age, the doctor usually ascribes to her contraception for the treatment period. Since there were cases when a newborn showed deviations similar to such symptoms of cancellation reactions (if his mother took preparations that included corpus delicti during pregnancy). This is especially true for the last third trimester of pregnancy. Against this background, the following symptoms may appear in a newborn:

• Cyanosis is a bluish color of the skin and mucous membranes, especially expressed in the area of the triangle of the upper lip.
• Convulsions and tremor.
• Respiratory distressive syndrome.
• Apnea - temporary respiratory arrest
• Temperature jumps.
• Vomiting and problems with feeding.
• Increased muscle tone.
• Hypoglycemia - a decrease in the concentration of glucose in the blood.
• And many others.

In most cases, these changes can be seen immediately after the birth of the baby or during the first 24 hours of life.

Based on the published data, it can be argued that the quantitative component of the active substance of the drug Zalkos and its metabolites in a woman’s milk during lactation is not significant. The clinical tests were also shown by their small doses in the blood of the newborn, in the case when the nursing mother took this therapeutic agent. But still there is a case when a significant concentration of cerrallin (approximately 50%) was recorded in the child’s blood. True, there was no noticeable effect on the baby’s health. Today, it is impossible to completely eliminate the risk of side pathology. Therefore, if possible, it is worthwhile to take the drug and feeding the child by time (during the treatment of the backlog you need to stop feeding).

Contraindications

Contraindications to the use of Zamols:

• Individual hypersensitivity to the component components of the drug.
• Do not attribute to children, exception can only be obsessive-compulsive disorders in babies older than six years of age.
• Contraindicated to the use of Zamols and together with the IMAO (monoaminoxidase inhibitors are biologically active substances that can inhibit the enzyme monoaminoxidase).

Side effects Zalox

Conducted laboratory and clinical studies under a placebo control, revealed such side effects of Zamols:

• Nausea, vomiting manifestations.
• Diarrhea (liquid, watery chair).
• Insomnia.
• Dyspepsia (painful digestion).
• Anorexia (mental disease of the digestive tract).
• Saw on the skin.
• Increased work of the sweat glands.
• Dry oral cavity.
• Dizziness.
• A failure in the reproductive capabilities of a man.
• Tremor.
• Tachycardia.
• Increased fatigue.
• Violation of the function of platelets.
• Arterial hypertension.
• And many other deviations.

The dependence of the manifestation of the side effects of Zalkos on the dosage taken was revealed. The “dangerous” amount of the drug was a dose of 200 mg of per diem.

[2], [3]

Overdose

In the case of use of Zabols as a drug of monotherapy, an overdose of sertralin gives such a symptoms:

• Nausea turning into vomiting.
• Drowsiness and apathy.
• The expansion of the pupils.
• Strengthening tachycardia.
• Change in the readings of the electrocardiogram.
• A feeling of anxiety.

In the case of this symptoms, the doctor prescribes supportive therapy:

• Reception of activated coal.
• The purpose of laxative preparations.
• Rinse of the stomach and intestines.
• Constant monitoring of cardiac activity.
• Control of all systemic physiological indicators.

To date, some specific antidotes that stop the pharmacodynamics of Zabols, and in particular hydrochloride cerrilin, has not been found. Fridays during an overdose of sealin was not observed.

Interactions with other drugs

Very carefully, various medications need to be combined in complex therapy, since they are capable of, as well as to strengthen the effect of each other, which is often dangerous and completely blocking the pharmacodynamics of their recipient.

In the process of work, some interactions of Zabols with other drugs were identified that cannot be discarded from shields during treatment.

So, with the complex prescription, Zabols with psychotropic drugs (for example, such as phenytoine, haloperidol, carbamazepine), with a daily dosage of hydraulic hydrochloride in 200 mg, there is no significant increase in psychomotoric and cognitive function. However, it is impossible to unequivocally say that the risk with such a joint administration is absolutely absent. Therefore, it is necessary to observe special caution in such a protocol of treatment.

There is no much experience in cases where there was a need to transfer the patient from another serotonergic drug to Zabols. Therefore, before making such a translation, it is necessary to weigh the pros and cons. And only if it won the pros, observing all caution, the medicine should be changed. This is especially true for prolonged drugs, since the duration of the “leaching” of the chemical is not established. It should also be avoided by the combination of drugs, the active substance of which is hydraulic hydrochloride.

During clinical studies, no significant changes in the pharmacokinetics of lithium preparations were revealed when they are jointly used with Zalks medicine. Although in this combination there were cases of tremor compared to placebo. Still, caution should be observed when taking them.

The integrated use of monoaminoxidase inhibitors (IMAO), with the drug under consideration, can lead to a sufficiently severe, sometimes fatal consequences. Often it looks like serotonin syndrome. Similar manifestations are observed with the simultaneous administration of two or more antidepressants with the IMAO, or in patients, who, after antidepressants, sharply began to take an IMAO. After therapeutic treatment with inhibitors, you can switch to the drug Zalks only after two weeks (or 14 days). And vice versa. It is possible to start taking an IMAO only two weeks after the end of the medical course is Zamols.

Most antidepressants work as antagonists of the biochemical mobility of the isoenzyme cytochrome, which occupies not the last place in the process of the metabolism of pharmacological drugs. This circumstance contributes to the growth of the quantitative indicator of the drugs taken in the blood. With the simultaneous combination of such combinations, it is necessary to remember the reduction of their dosages.

Although there was no significant suppression of cognitive and psychomotor functions of the Zalkos medicine when using it along with alcoholic beverages, but, nevertheless, you should not experiment. During the treatment of a patient with depressive syndrome, alcohol is better “excluded from the menu” of the patient. If it is necessary to use cerralin together with insulin (or other hypoglycemic drugs), it is necessary to constantly monitor the level of glycemia in the patient.

With the joint use of digoxin and backlogs, no significant changes in the pharmacodynamics of both drugs were detected. But Tsimetidine’s intake is able to significantly block the metabolism of sertralin, which negatively affects its clearance. This, in turn, leads to an increase in the likelihood of side effects. The clinical consequences of the interaction of the drug Zalkos with Diazepam are not thoroughly investigated, so it is necessary to use such a combination very carefully.

We need constant monitoring of the “prothrombin time” with tandem of a sorelin with warfarin. This need follows from the fact that corpus delicti is easily binded to the protein component of blood plasma (almost 98%). And the deposition of the blockage along with other medicines that have “abilities” similar to ceretralin can lead to an increase in the concentration of drugs in the blood, and from here to side effects.

There is no evidence that with prolonged use of the drug Zabols, addiction and dependence may occur. However, such a factor should not be allowed on a gear, you should more thoroughly examine the patient history, the purpose of which is to identify other cases of drug dependence.

There were no cases of death. Although, with an overdose of hydraulic serapy hydrochloride, combined with other drugs and alcohol, several deaths were still ascertained.

[4], [5], [6]

Storage conditions

Store in a dry place for young children and adolescents. The temperature in the room should be in the range from 15 to 30 ° C - these are all storage conditions of the blockage that are required.

Shelf life

Five years is the shelf life that the manufacturer indicates the packaging of the drug. After its expiration, pharmacologists do not recommend applying the drug Zalkos.