Zalayin ovuli

Zalain ovuli is a topical agent intended for the treatment of fungal infections caused by yeast-like fungi belonging to the genus Candida. The mechanism of action of this drug used as a remedy for thrush is as follows. As a result of its use, the permeability of cell membranes increases and the processes that produce ergosterol are suspended. The consequence of this is the onset of lysis of fungal cells, which means disintegration as a result of their outer membranes dissolving due to the action of lysosomes.

The method of using Zalain Ovuli suppositories for thrush is their intravaginal administration. Before using them, the genitals should be thoroughly washed with soap. To achieve a healing effect, suppositories should be inserted as far as possible into the vagina, while lying on your back. This should be done before going to bed. If the use of this drug has not produced the desired effect and there is a further manifestation of symptoms of the disease after a week, it may be necessary to re-administer the drug.

During the entire period of treatment for candidal disease, it is recommended to avoid sexual intercourse, and it is desirable that the woman's partner also undergo treatment with this drug together with her. The introduction of suppositories should not be stopped even during regular menstrual bleeding.

This medicine should be used with caution if a woman has hypersensitivity to imidazole and benzothiophene derivatives and other components contained in it. During pregnancy and breastfeeding, it is better to avoid using the drug if possible.

Indications Zalayin ovuli

Indications for the use of Zalain ovuli suggest its use in one form or another, in which this remedy is presented. So, in the form of a cream, this drug can be prescribed to promote healing from a number of diseases, including superficial skin mycoses, which are caused by the action of yeast and dermatophytes. They are represented by dermatomycosis of smooth skin and bone dermatomycosis, candidiasis, versicolor lichen. They also include inguinal dermatophytosis, epidermophytosis of the shin and feet, and trichophytosis of the mustache and beard area.

Indications for the use of Zalain ovuli suppositories are determined by the presence of the following diseases. Intravaginal administration of the drug helps to cure infections caused by fungi and affecting the mucous membranes of the vagina. These also include mixed infections, a combination of which is formed by gram-positive bacteria.

This remedy for thrush is currently one of the best drugs for combating candidal diseases. But despite this circumstance, before starting to use it, it would be absolutely useful to consult a medical specialist. The mere fact of detecting a fungus in a woman's body, not accompanied by the presence of symptoms of a significant degree of severity, does not represent a sufficient justification for the need to use this drug.

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Release form

The drug is available in two main forms: in the form of a cream and in the form of vaginal suppositories.

Zalain cream is a semi-solid melting mass, white in color and odorless, or it may have a slight smell of fat. The cream is filled into aluminum tubes of 20 grams each, which have a screw cap made of plastic. The packaging for the tube is a cardboard box, in which it is placed together with a folded sheet of instructions for use.

Zalain cream is an antifungal preparation intended for external use. It contains 0.4 grams of sertaconazole nitrate, which in relation to 20 grams of total mass gives a 2% concentration of the healing substance. In addition to it, the cream contains various auxiliary ingredients: purified water, liquid petroleum jelly, saturated polyglycolized glycerides, glycerol isoasterate, E218 (methyl parahydroxybenzoate) and sorbic acid.

The drug Zalain ovuli is another form of release of this drug. It has the form of vaginal suppositories, 0.3 grams each, packed in blister packs. The composition of the drug includes sertaconazole nitrate in combination with aerosil 200 and solid semi-synthetic glycerides Suppocire NAI 50 and Witepsol H19.

Pharmacodynamics

Pharmacodynamics of Zalain ovuli is caused and is connected mainly with the pharmacological action of the drug sertaconazole. It is a derivative of benzothiophene and imidazole, and is characterized by pronounced fungicidal properties, manifested in active resistance to pathogenic infections of fungal origin. These include blastomycetes Candida albicans, Candida subspecies, Malassezsa furfur; dermatophytes Epidermophyton floccosum, Microsporum spp, Trichophyion. Its active effect is also directed against infectious lesions of the mucous membranes provoked by gram-positive pathogens Streptococcus, Staphylococcus.

The mechanism of action, which distinguishes the pharmacodynamics of Zalain ovuli, is that the sertaconazole contained in it helps to suppress the processes of ergosterol synthesis, and also due to it, the degree of permeability of the fungal cell membrane increases. As a result of this phenomenon caused by the drug, lysis of fungal cells occurs. Lysis is characterized by the destruction of the outer cell membranes as a result of their dissolution under the influence of lysosomes.

Pharmacokinetics

The pharmacokinetics of Zalain ovuli is characterized by the absence of systemic absorption. Local application excludes subsequent detection of sertaconazole in urine and blood plasma.

Dosing and administration

The method of administration and dosage of the drug depend on the form and method of administration of Zalain ovuli.

The cream should be applied one to two times a day. It should be evenly distributed over the affected skin surface, while capturing about 1 centimeter of healthy skin along the edges of the treated area. To determine the duration of treatment, it is necessary to be guided by the features of the location of the infected area, as well as based on what exactly was the causative agent of the disease. After a 4-week course of treatment, one can expect that the clinical symptoms will disappear, and recovery will be confirmed by the results of microbiological analysis. The tendency to restore a healthy state, however, begins to manifest itself, mainly, already in the third week of the treatment course.

Suppositories for intravaginal use by adults are inserted in the amount of one per day deep into the vagina before bedtime. As a rule, a single use is sufficient to completely cure vaginal infections. Otherwise, after a week, the drug is re-used. Before inserting the suppository, the external genitalia are washed with water and alkaline or any neutral soap.

Use Zalayin ovuli during pregnancy

The use of Zalain ovuli during pregnancy, as well as all other medications, requires increased caution. After all, a woman must remember that when carrying a child, she becomes responsible not only for her own health, but also for the absence of dangers and avoidance of all kinds of negative factors that can affect the development of a new life, the care of which is entrusted to her. One can cite a large number of both "Pros" and "Cons" of using Zalain ovuli during pregnancy. There is much evidence that Zalain ovuli is highly effective in the fight against thrush. The indisputable advantage of this drug is that, as many of its existing descriptions unanimously claim, just one-time use can lead to the achievement of a healing effect. It is also stated that this drug is not characterized by the phenomenon of systemic absorption. This is undoubtedly a positive factor.

But, on the other hand, there is also a statement that the use of Zalain ovuli during pregnancy has not been studied sufficiently to say with all confidence that it is supposedly completely harmless to the health of the baby. Therefore, it is necessary to think carefully and weigh everything regarding the advisability of using this drug, whether it will really bring more benefit to the expectant mother than it can adversely affect the development of the baby. In addition, it cannot but be alarming that in the list of contraindications, along with hypersensitivity, pregnancy is often also indicated, and in other cases there is no such categorical contraindication. That is, this indicates that the topic of how pregnancy is compared with taking this drug has not been studied enough by the manufacturer itself to give a definitive answer to this question. Due to this, it is better not to take risks without special need.

Contraindications

Contraindications to the use of Zalain ovuli arise on the basis that there is a strong reaction to sertaconazole, as well as in relation to other imidazole derivatives. In addition, a prohibitive factor is the presence of hypersensitivity to any of the other components of the drug.

Zalain cream is under no circumstances approved for use as an ophthalmic agent.

During pregnancy and lactation, contraindications to the use of Zalain ovuli externally are justified by the fact that studies to determine its concentration in blood plasma have not been conducted, and its harmlessness to a pregnant woman and the unborn child is not an established fact. For this reason, the drug can be prescribed only based on the degree of appropriateness and the predicted greater benefit for the woman than the negative consequences for the intrauterine development of the child. Zalain ovuli during pregnancy should be taken only after consultation and as prescribed by a medical specialist.

The peculiarities of using this remedy by intravaginal administration should be the exclusion of douching with soap, which is characterized by an acidic pH. It is recommended to use cotton underwear.

Side effects Zalayin ovuli

Since the pharmacologically active substance is present in an insignificant concentration, and also based on the method of application, the possibility of an overdose seems extremely unlikely. In addition, when using the drug vaginally, there is no systemic absorption of the sertaconazole contained in it, which helps reduce the likelihood of any negative consequences.

Side effects of Zalain ovuli occur in case of accidental ingestion and may manifest as a local transient irritant reaction - itching and burning sensation. The cause of such unpleasant sensations is the death of pathogens and the effect exerted by cellular fragments. Thus, this may also be evidence of the effectiveness of the therapy used. Treatment of side effects due to accidental use of the drug is exclusively symptomatic.

Side effects of Zalain ovuli may be expressed in the appearance of allergic reactions. Among the negative consequences associated with the use of the cream, cases were noted when during the first days of such a treatment course there was an erythematous reaction. However, it was insignificant, transient and manifested itself over a short period of time. As a result, it was not necessary to cancel the drug.

Overdose

Overdose of Zalain ovuli seems possible with an extremely low probability. This is explained by the fact that the drug has a very low concentration of its main active substance. Due to the peculiarities of the form and method of application, it is also excluded that this product can enter the body in excessive quantities that can lead to any significant negative consequences. Vaginal suppositories are administered in the amount of no more than one unit at a time, and the cream cannot be smeared or accidentally swallowed so much as to reach a concentration that could pose a health hazard.

The fact that sertaconazole, which it contains, is not subject to systemic absorption is another factor in reducing the risk of any kind of dysfunction of the body.

In the event that a burning or itching sensation does appear, as a local transient irritant reaction, in order to completely protect yourself after an unintended ingestion of the drug, a completely sufficient measure is gastric lavage and symptomatic treatment.

Interactions with other drugs

Interactions of Zalain ovuli with other drugs, as for the cream, it should be noted that any obvious and significant changes in the basic properties and effectiveness of its use in the direction of strengthening or weakening the therapeutic effect produced by it were not noted. Zelain, used in a complex, where local contraceptives are included in addition to it, causes a tendency to reduce the expression of their spermicidal properties.

Another feature of the interaction of Zalain ovuli with other drugs is that, in particular, one should refrain from using it together with a pessary or latex condoms.

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Storage conditions

The storage conditions of Zalain ovuli in their basic requirements do not differ significantly from the rules that must be followed when storing most medications.

One of the conditions is traditionally the recommendation that the medicine be kept in a place that excludes the possibility that it can fall into the hands of children. Such a place, in which the medicine is placed, must meet a number of requirements, in particular, to the storage temperature. So, with regard to the cream, the temperature should not exceed 25 degrees Celsius, and suppositories for intravaginal administration should be kept at a temperature of up to 30 ° C. At home, in the absence of specially equipped storage areas for pharmacological products like in pharmacies, you can keep Zalain ovuli on the shelves of the refrigerator. It is necessary, however, to monitor the condition of the medicines in order to prevent them from freezing. If this does happen, it is strictly not recommended to use such medicines.

Excessively high temperature is also a factor that makes the storage conditions of Zalain ovuli unfavorable. This is due to the fact that in such a case, changes in the properties of the drug may occur associated not only with a decrease in the ability to achieve the desired therapeutic effect, but also with an increased likelihood that harm may be caused to the body.

Shelf life

The shelf life of Zalain ovuli is 3 years.

It is necessary, however, to pay attention to the fact that the drug is able to maintain maximum efficiency of its action and useful healing properties during the specified time period only if it is stored in optimal conditions for itself. This implies, first of all, ensuring and maintaining the necessary storage temperature.

On the packaging of most medicines, manufacturers of pharmaceutical products indicate the expiration date that can be expected if the drug is stored under the appropriate required conditions. When opened and removed from the packaging, due to interaction with the environment and the resulting chemical reactions, drugs undergo a change in properties, for example, they can exhibit different pharmacological activity. In addition, the use of an expired drug is associated with a significant risk of intoxication or any other harm caused to the body.

Thus, it is necessary to take into account that a drug with an expired shelf life will at least not be able to bring any benefit from its use, and at worst, it can cause all sorts of negative consequences for health.