Vasilip

Vasilip is a drug designed to lower cholesterol. It is used by patients with cardiovascular problems. Today, almost every second person has high cholesterol. This phenomenon must be combated not only by eliminating harmful products, but also with medication.

Indications Vasilipa

In what cases should the drug be taken, and what are the main indications for the use of Vasilip? First of all, the risk group consists of people with hypercholesterolemia. At the first stage and with mixed dyslipidemia, this drug is widely used.

Vasilip is used in addition to diet when other methods are ineffective. These include increased physical activity, which does not bring any results.

Homozygous heredity is also the main indication for the use of the drug. It is used in addition to diet, if these measures are ineffective. Vasilip is prescribed as a preventive measure for the cardiovascular system.

Patients with diabetes also take this remedy. It helps reduce cardiovascular mortality and morbidity with clinical manifestations of atherosclerosis.

As an additional measure to correct other risk factors, this drug is prescribed. Vasilip is used for normal and elevated cholesterol levels.

Release form

The drug is available only in tablet form. They are intended for internal use. The tablets are film-coated. One blister contains 10, 20 or 40 mg. This figure indicates the content of the active substance in the tablet.

One package contains 14 or 28 tablets. It all depends on the packaging itself and the active substance in one capsule. There are no other options. This fact should be taken into account when purchasing the product.

To date, there have been cases of counterfeit purchases. Therefore, preference should be given exclusively to proven pharmacies. You should also pay attention to the packaging, which comes in only two types.

Vasilip is not supplied in the form of syrups, injections and other options. Only tablets covered with a special shell. Much depends on the capacity of the active substance in one tablet. Vasilip has several variations, which is necessary, the doctor decides depending on the effect.

Pharmacodynamics

Pharmacodynamics of the drug indicate that the active substance is simvastatin. The main effect of this medication is to reduce the content of total cholesterol and LDL cholesterol in the blood plasma.

Simvastatin is a 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitor. This enzyme catalyzes the conversion of HMG-CoA to mevalonic acid. This occurs at an early stage of cholesterol synthesis. The active substance is able to reduce the concentration of total cholesterol. The content of very low-density lipoprotein cholesterol is also reduced. The substance actively reduces the level of total cholesterol. Thus, the risk of myocardial infarction and death is reduced.

Simvastatin is able to significantly reduce the content of apolipoprotein B. At the same time, it moderately increases the concentration of HDL cholesterol. The anti-atherosclerotic effect of the drug is a consequence of the effect of the active substance on the walls of blood vessels and blood components. Simvastatin changes metabolism, while inhibiting the activation. Macrophages and the destruction of atherosclerotic plaques. The therapeutic effect of taking Vasilip is observed after 2 weeks, it reaches its maximum after a month and a half.

Pharmacokinetics

The pharmacokinetics of the drug is represented by the fact that the active substance itself belongs to the inactive lactone form. It is perfectly absorbed from the gastrointestinal tract (61-85%). The bioavailability of the drug is less than 5%. After taking the medication, its maximum concentration in the blood plasma is reached literally in 1-2 hours and gradually decreases after 12 hours.

Simultaneous food intake does not affect the drug's acceptance. Absorption occurs at the same level. If the drug is taken for a long time, no accumulation in the body occurs. The drug binds to blood plasma proteins by 98%.

Simvastatin is a CYP3A4 substrate. It can be metabolized in the liver. It has a "first pass" effect through the liver. The drug is mainly hydrolyzed into its active form. The drug is excreted by the intestines by 60%. Almost 13% is excreted by the kidneys, and in an inactive form. This allows us to call Vasilip a high-quality and effective product.

Dosing and administration

The method of application and doses of Vasilip depend solely on the person's disease. Thus, during hypercholesterolemia, it is recommended to take 10 to 80 mg of the drug in the evening. The dosage depends on the specific situation; it cannot be increased independently.

The initial dose has always been considered to be 10 mg per day. This figure can be increased only after a month from the start of taking. The maximum dose is 80 mg per day at a time. The use of the drug does not depend on food intake.

If we are talking about hereditary hypercholesterolemia, then you need to take 40 to 80 mg per day. Moreover, the drug is taken at one time. The dose depends on the severity of the disease.

Ischemic heart disease. In this case, it is recommended to start with 20 mg per day. The maximum permissible is 40 mg per day. The dosage level can be increased only after a month. People suffering from renal failure or being of advanced age cannot increase the dose. 10 mg of Vasilip per day is quite enough.

[ 1 ]

Use Vasilipa during pregnancy

The use of Vasilip during pregnancy is contraindicated. There is no evidence of the drug's effect on the development of congenital defects in children whose mothers took this drug.

Use of Vasilip by a pregnant woman may result in decreased levels of mevalonate in the fetus. This is a precursor to cholesterol biosynthesis. If lipid-lowering agents are discontinued during pregnancy, this does not significantly affect the short-term risk results. This is due to primary hypercholesterolemia.

Simvastatin is not recommended for use by women who are planning pregnancy or suspect that they may become pregnant. If this occurs during treatment with the drug, it should be discontinued immediately. The woman should be warned of the possible danger to the fetus.

It is unknown whether the medicine penetrates into breast milk or not. Therefore, during lactation, it is not recommended to use Vasilip, perhaps a slight effect on the body.

Contraindications

There are also contraindications to the use of Vasilip, which should be followed. Thus, in case of acute liver diseases, the drug should not be used under any circumstances. It can affect this organ in a special way and worsen the situation.

A persistent increase in transaminase levels, and of unknown origin, is also a contraindication. This can lead to the development of abnormal reactions on the part of the body.

People who have hypersensitivity to the components of the drug are especially dangerous. In this case, you need to consult a doctor. After all, severe allergic reactions may occur when using it. It is advisable to choose a similar product or a medicine with a more gentle composition. There are cases when you need to take the medicine, but the person has hypersensitivity. This means that you need to look for alternative solutions to the problem. But it is strictly forbidden to use Vasilip.

Side effects Vasilipa

Side effects of Vasilip manifest themselves in almost all systems and organs. Thus, the gastrointestinal tract suffers first. In this case, dyspepsia, nausea, vomiting, constipation and diarrhea may occur. Everything depends on the concentration of the drug in the human body. Increased activity of liver transaminases and development of pancreatitis are possible.

From the side of the central nervous system, headache, increased fatigue, development of depression, dizziness and even sleep disturbance are possible. Muscle weakness and myopathy appear, which is characterized by an increase in the level of muscle fraction. Thus, muscles manifest themselves.

In extremely rare cases, rhabdomyolysis may develop, which is accompanied by subsequent renal failure. The risk of developing this disease increases in those people who take cyclosporine.

The genitourinary system manifests itself in the form of kidney dysfunction and potency. The organs of vision are characterized by crystalline clouding. Allergic reactions are also possible, such as skin rash, vasculitis, itching, eczema, and increased body temperature.

Other effects were also observed, such as alopecia and photosensitivity. In general, Vasilip is well tolerated by patients. Side effects occur in rare cases and quickly pass.

Overdose

An overdose of Vasilip occurs if the dose of simvastatin is increased. However, no serious consequences were observed in this case. No serious violations were detected, especially those of a specific nature.

In case of overdose, the stomach should be washed immediately. Then begin monitoring the functions of the body's systems, with special attention paid to the liver and kidneys. The content of the muscle fraction of creatine phosphokinase in the blood plays a significant role.

If there is a risk of developing rhabdomyolysis or acute liver failure, it is worth performing hemodialysis. If any negative reactions from the body occur, it is necessary to rid it of the drug and stop taking it. In this case, a doctor's consultation is necessary. Because it is not always possible to stop using the medication.

Overdose occurs extremely rarely. This is often facilitated by an independent increase in the dose. Therefore, Vasilip should be taken strictly according to the instructions.

Interactions with other drugs

Interactions with other drugs are possible, but special caution is required. Simvastatin in combination with fibrates, erythrocymin, nicotinic acid and nefazodone significantly increases the risk of rhabdomyolysis. All this can develop into subsequent renal failure.

Similar complications can be caused by amiodarone or verapamil. They should be combined with simvastatin with caution. High doses are unacceptable. Ritonavir can increase the level of simvastatin in the blood. The complex combination of the active substance with warfarin contributes to the appearance of anticoagulant properties. This increases the risk of hemorrhagic complications.

It is not recommended to use simvastatin together with digoxin. Such a combination can lead to high concentrations of substances in the blood. In this case, it is worth consulting a doctor. If a person takes several medications at the same time, then this should be done with caution. Vasilip may not interact with many of them, which will complicate the situation.

[ 2 ], [ 3 ]

Storage conditions

Storage conditions of Vasilip are the main criterion. Thus, it is necessary to follow special rules so that the drug can serve for a specified period of time. First of all, it is worth choosing a dry and warm place. Dampness is the main enemy of any medicine.

Direct sunlight and cold should be removed. In no case should the medicine be exposed to freezing. In this case, it will lose all its useful properties and become unsuitable for use.

The drug is especially dangerous for children, as is the drug for them. The drug can have a negative effect on the child's body, which will lead to the development of uncontrolled processes. The baby can damage the packaging and thus lead to the rapid deterioration of the tablets. This factor is unacceptable, so it is worth hiding the drugs from the child.

Following certain rules will allow you to use the drug for 2 years. The main thing is to monitor its external data. In this case, Vasilip will have the necessary effect and will not harm the body.

[ 4 ], [ 5 ]

Shelf life

The shelf life directly depends on the storage conditions. If you do not comply with them, then you should not even pay attention to the number on the package. The fact is that drugs require a certain storage place. Otherwise, they quickly become unusable.

It is important to create ideal conditions. It is advisable to store the medicine in a medicine cabinet with other drugs. If there is none, then a dry, warm place without moisture will do. The latter negative factor can lead to rapid deterioration of the tablets.

Temperature conditions play a huge role. You should not cross a certain barrier of 15-25 degrees. Otherwise, you should not hope for the positive properties of the medicine.

And finally, a change in the smell and color of the tablet indicates that it is not suitable for use. Most likely, some conditions were not met correctly. In this case, it is not recommended to take the drug. The expiration date is just a number, much depends on how a person stores the drug Vasilip.