Wazilip

Vasilip is a drug designed to lower the level of cholesterol. It is used by patients who have problems with the cardiovascular system. To date, an increased level of cholesterol is found in almost every second person. With this phenomenon it is necessary to fight not only by eliminating harmful products, but also medicamentally.

Indications of the wazilip

When should I take medicine, and what are the main indications for use of Vasilip? The first thing a group of people at risk is hypercholesterolemia. At the first stage and with mixed dyslipidemia this agent is widely used.

Apply Vasilip in addition to the diet with ineffectiveness of other methods. These include increased physical activity, which do not bring any result.

Homozygous heredity is also the main indication for the use of the drug. Use it in addition to diet, if these measures are ineffective. As a prophylaxis of the cardiovascular system, the administration of Vasilip is prescribed.

A patient with diabetes mellitus also take this remedy. It helps to reduce cardiovascular mortality and morbidity with the clinical manifestations of atherosclerosis.     

As an additional measure to correct other risk factors., Prescribe this drug. Applied Vasilip with normal and elevated cholesterol. 

Release form

The form of the preparation is only in the form of tablets. They are intended for internal use. Film coated tablets are covered. In one blister is 10, 20 or 40 mg. This figure indicates the content of the active substance in the tablet.

One package contains 14 or 28 tablets. Everything depends on the actual packaging and the active ingredient in one capsule. There are no other options. This fact should be considered when buying a product.

To date, there have been recorded cases of purchase of fakes. Therefore, preference is given exclusively to proven pharmacies. Pay attention to the packaging, which is only two kinds.

In the form of syrups, injections and other options, Vazilip is not supplied. Only tablets covered with a special coating. Much depends on the capacity of the active substance in one tablet. Vazilip has several variations, which is necessary, the doctor decides depending on the effect. 

Pharmacodynamics

Pharmacodynamics of the drug suggests that the active substance is simvastatin. The main effect of this medication is to reduce the total cholesterol and LDL cholesterol in the blood plasma.

Simvastatin refers to inhibitors of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonic acid. This happens at an early stage in the synthesis of cholesterol. Active substance can reduce the concentration of total cholesterol. The content of very low density lipoprotein cholesterol is also reduced. The substance actively reduces the level of total cholesterol. Thus, the risk of myocardial infarction and death is reduced.

Simvastatin is able to significantly reduce the content of apolipoprotein B. Moreover, it moderately increases the concentration of HDL cholesterol. The antiatherosclerotic effect of the drug is a consequence of the action of the active substance on the walls of blood vessels and components. Simvastatin alters the metabolism, while inhibiting activation. Macrophages and destruction of atherosclerotic plaques. The therapeutic effect of taking Vazilip is observed after 2 weeks, its maximum reaches one and a half months.

Pharmacokinetics

Pharmacokinetics of the drug is represented by the fact that the active substance itself refers to an inactive lactone form. It is perfectly absorbed from the digestive tract (61-85%). Bioavailability of the drug is less than 5%. After taking the drug, its maximum concentration in the blood plasma is reached literally in 1-2 hours and gradually decreases after 12 hours.

Simultaneous food intake for taking the drug does not affect. Absorption occurs at the same level. If the medicine is taken for a long time, then no cumulation in the body occurs. With blood plasma proteins, the drug binds to 98%.

Simvastatin belongs to the substrate CYP3A4. It is able to be metabolized in the liver. He has the effect of "first passage" through the liver. Basically, the drug hydrolyzes into its active form. The intestinal medicine is withdrawn by 60%. Almost 13% of them excrete the kidneys, and in an inactive form. This allows us to call Vazilip a quality and effective product. 

Dosing and administration

The method of administration and dose of Vasilip depends solely on human disease. So, during hypercholesterolemia it is recommended to use 10 to 80 mg of the drug in the evening hours. Dosage depends on the specific situation, it is impossible to increase it on its own.

The initial dose was always 10 mg per day. It is possible to increase this figure only one month after the beginning of the admission. The maximum dose is 80 mg per day at a time. The use of the medicine does not depend on the consumption of food.

If we are talking about hypercholesterolemia of a hereditary nature, then a day should be consumed from 40 to 80 mg. And the remedy is taken at a time. The dose depends on the severity of the disease.

Cardiac ischemia. In this case it is recommended to start with 20 mg in knocking. The maximum allowed is 40 mg per day. You can only increase the dosage level in a month. Persons suffering from kidney failure or elderly age can not be increased. It is enough for 10 mg of Vazilip per day. 

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Use of the wazilip during pregnancy

Use of Vasilip during pregnancy is contraindicated. There is no evidence of the effect of the drug on the development of congenital malformations in children whose mothers took this drug.

Using a Wazilip by a pregnant woman can lead to a reduction in mevalonate levels in the fetus. This is the precursor of cholesterol biosynthesis. If you cancel taking hypolipidemic drugs during pregnancy, this does not have a significant effect on the results of short-term risk. This is due to primary hypercholesterolemia.

It is not recommended to use simvastatin for women who plan a pregnancy or if it is suspected of being pregnant. If this has occurred during the treatment with the drug, then immediately withdraw it. A woman needs to be warned about the possibility of danger to the fetus.

 It is not known whether the medicine penetrates into breast milk or not. Therefore, in the lactation period, it is not recommended to use Vasilip, possibly a minor effect on the body. 

Contraindications

There are also contraindications to the use of Vasilip, which should be adhered to. So, in case of acute liver diseases, you should never use a medicine. He has a special way to influence this body and aggravate the situation.

A persistent increase in the content of transaminase, with an unexplained genesis also refers to a number of contraindications. This can lead to the development of abnormal reactions from the body.

Particularly dangerous are people who are hypersensitive to the components of the drug. In this case, a doctor's consultation is necessary. After all, severe allergic reactions may occur during use. It is desirable to choose a similar remedy or medicine with a more gentle composition. There are cases when you need to take medicine, and a person has hypersensitivity. This suggests that you need to look for alternative ways to solve the problem. But using Vasilip is strictly prohibited. 

Side effects of the wazilip

Side effects of Vazilip show themselves almost all systems and organs. So, first of all the gastrointestinal tract suffers. In this case, dyspepsia, nausea, vomiting, constipation and diarrhea are not excluded. Everything depends on the concentration of the drug in the human body. It is possible to increase the activity of hepatic trasaminases and the development of pancreatitis.

From the central nervous system, headache, fatigue, depression, dizziness and even sleep disturbance are possible. There is a muscle weakness and myopathy, which is characterized by an increase in the level of muscle fraction. Thus, the muscles manifest themselves.

In extremely rare cases, the development of rhabdomyolysis, which is accompanied by subsequent renal failure, is possible. The risk of developing this disease increases in those people who take cyclosporine.

The genitourinary system manifests itself in the form of impaired renal function and potency. Vision organs are characterized by turbidity of the crystal. Possible and allergic reactions, it is a skin rash, vasculitis, itching, eczema and fever.

There were other effects, such as alopecia and photosensitization. In general, Vazilip is well tolerated by patients. Side effects occur in rare cases and quickly pass. 

Overdose

Overdose Vasilip occurs if the dose of simvastanin is increased. True, there were no serious consequences in this case. Serious violations have not been identified, especially those that are specific.

In case of an overdose, immediately wash the stomach. After that, to begin monitoring the functions of the body's systems, special attention is paid to the liver and kidneys. The content of the muscle fraction of the creatine phosphokinase of blood plays no small role.

If there is a threat of development of rhabdomyolysis or acute liver failure, it is necessary to perform hemodialysis. If there are any negative reactions from the body, you need to get rid of the drug and stop taking it. In this case, a doctor's consultation is necessary. Because it is not always possible to cancel the use of the medication.

Overdosing occurs very rarely. This is often facilitated by an independent increase in the dose. Therefore, you should take Vasilip clearly according to the instructions. 

Interactions with other drugs

Interactions with other drugs are possible, but you need to take extra care. Simvastatin in combination with fibrates, erythrocymine, nicotinic acid and nefazodone significantly increases the risk of rhabdomyolysis. All this can flow into a subsequent renal failure.

 Similar complications can cause and amiodarone or verapamil. Combine them with simvastatin should be carefully. A high dose of application is unacceptable. Ritonavir can increase the level of simvastatin in the cut. A complex combination of active substance with warfarin promotes the appearance of anticoagulant properties. This increases the risk of hemorrhagic complications.

 Use simvastatin along with digoxin is not recommended. This combination can lead to a high concentration of substances in the blood. In this case, it is worth consulting with a doctor. If a person takes several medications at the same time, then it should be done cautiously. Vazilip may not interact with many of them, which will lead to more complicated situations. 

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Storage conditions

Storage conditions are the main criterion. So, it is necessary to observe special rules, so that the drug can serve for a specified time. The first thing is to pick up a dry and warm place. Dampness is the main enemy of any medication.

 Direct sunlight and coolness should be removed. In no case should the medicament be exposed to frost. In this case, it will lose all its useful properties and become unsuitable for use.

For children, the drug is a particular danger, as it is for him. On the child's body, medicine can affect negatively, which will lead to the development of uncontrolled processes. The baby is able to damage the packaging and thereby lead to rapid damage to tablets. This factor is unacceptable, so it is worthwhile to hide drugs from the child.

Compliance with certain rules will allow using the drug for 2 years. The main thing is to monitor his external data. In this case, Vazilip will have the necessary action and will not harm the body. 

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Shelf life

The expiration date directly depends on the storage conditions. If you do not comply with them, then the indicated figure on the package is not even worth paying attention to. The fact is that the drugs require a specific storage location. Otherwise, they quickly become unusable.

It is important to create ideal conditions. It is desirable to store the medication in the medicine cabinet with other medications. If it is not there, a dry, warm place without moisture will do. The latter negative factor can lead to rapid damage to tablets.

The temperature regime plays a huge role. You do not need to cross a certain barrier at 15-25 degrees. Otherwise, hope for the positive properties of the drug is not worth it.

Finally, the change in the smell and color of the tablet suggests that it is not usable. Most likely, some conditions were met incorrectly. In this case, taking the remedy is not recommended. The expiration date is just a figure, much depends on how a person stores the drug Vazilip.