Vibrocil

Vibrocil is a decongestant medication; it is a vasoconstrictor substance that acts on the nasal mucosa. It has a complex composition (dimetindene, which is an antagonist of H1 endings, and also a sympathomimetic phenylephrine).

The drug has a long and very rapid vasoconstrictor effect on the venous bed of the nasal mucosa with the paranasal sinuses. Weakens disease-causing exudation and improves the activity of the ciliated epithelium. The combination with dimethindene causes the development of antiallergic effects. [1]

Vibrocil is a local remedy, therefore its therapeutic activity is not determined by the blood level of the active elements.

Indications Vibrocil

It is used to treat manifestations of respiratory colds (swelling of the nasal mucosa). Also used in such cases:

• runny nose in an active or chronic stage;
• runny nose with vasomotor or allergic etiology;
• polysinusitis, as well as sinusitis in the active or chronic phase;
• preparation process before carrying out manipulations or diagnostic procedures in the area of the nasal cavity;
• preparation for the operation or postoperative elimination of puffiness after the procedure in the area of the nasal cavity.

Release form

The release of drugs is made in the form of nasal drops - inside 15 ml bottles. In addition, it is realized in the form of a spray - inside bottles equipped with a spray (volume 15 ml). It can also be produced in the form of a gel - inside a 12 g tube.

Pharmacodynamics

Phenylephrine is an amine sympathomimetic. It is used in the form of a nasal decongestant, which has a moderate vasoconstrictor effect, and in addition, it selectively stimulates the activity of α1-adrenergic endings inside the venous cavernous tissues of the nasal mucosa. [2]As a result, the swelling of the nasal mucosa with the paranasal sinuses disappears quickly and for a long time. [3]

Dimetindene is a substance with an antagonistic effect on the H1-endings of histamine; has anti-allergic properties. Effective when administered in small portions and tolerated without complications. [4]

Pharmacokinetics

In the case of unintentional intake of drugs inside, there is a decrease in the level of bioavailability of phenylephrine - about 38%. This is due to metabolic processes during the 1st intrahepatic and intestinal passage. The half-life is approximately 2.5 hours.

The systemic indicators of the bioavailability of dimethindene after oral administration of the solution are approximately 70%; half-life is approximately 6 hours.

Dosing and administration

Drops of drugs for infants up to 12 months of age are injected in 1 drop into each of the nostrils, 3-4 times a day. At the age of 1-6 years - 1-2 drops, 3-4 times a day. For persons over the age of 6, use 3-4 drops, 3-4 times a day.

The gel is injected deep into the nasal passage. The procedure is carried out 3-4 times a day. Appointed only for persons over 6 years of age.

The spray is also used only in people from 6 years old. It is necessary to make 1-2 injections inside each nostril, 3-4 times a day. The procedure should be performed while keeping the head upright, taking shallow breaths after applying the drugs. The bottle is held with the spray upwards, and the injection is performed with a light pressure.

The duration of the cycle is equal to the 1st week.

• Application for children

The medicine in the form of a spray and gel is not used by persons under 6 years of age.

Use Vibrocil during pregnancy

Vibrocil is forbidden to appoint during breastfeeding or pregnancy.

Contraindications

Among the contraindications:

• severe intolerance to the elements of the drug;
• runny nose, which has an atrophic form;
• administration in combination with substances from the MAOI subcategory.

Side effects Vibrocil

Occasionally, the use of drugs leads to nasal dryness or burning.

Overdose

With an accidental oral intake of the medicine, the child did not notice any serious manifestations. Pains in the abdominal area, sleep disorders, severe fatigue, increased blood pressure values, agitation, palpitations and pallor of the mucous membranes with the epidermis appeared singly.

The medicine has no antidote. Symptomatic actions are performed (taking laxatives and enterosorbents, as well as drinking a large amount of liquid).

Interactions with other drugs

The drug contains phenylephrine, which is why it is forbidden to combine it with MAOIs. In cases where the patient is already using MAOIs, the use of Vibrocil is allowed only after at least 2 weeks from the date of the last administration of MAOIs.

Care should be taken to use the medicine in people using tricyclics and antihypertensive medicines from the subcategory of β-adrenergic receptor activity blockers.

Storage conditions

The vibrocyl should be kept in a dark place, away from any heating apparatus. Temperature readings - maximum 30 ° C.

Shelf life

Vibrocil can be used within 36 months from the date of manufacture of the drug substance.

Analogs

An analogue of the drug is the Grippocitron Rinos remedy.

Reviews

Vibrocil receives generally good reviews from patients. It quickly eliminates nasal congestion, has an anti-allergic effect and has a convenient shape for use. Of the minuses, the short duration of the therapeutic effect and the high cost of the medication are noted.