Medical expert of the article
New publications
Preparations
Venosmil
Last reviewed: 23.04.2024
All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
Venousmil is a capillary stabilizing drug from the category of angioprotectors. Contains bioflavonoids.
Indications Venosmila
It is used to relieve the swelling and signs caused by the insufficiency of veins, which has a chronic character (application of the drug is possible for a short period of time - a maximum of 2-3 months).
Release form
The release of drug substance is realized in capsules, 10 pieces inside a blister pack. The pack contains 6 or 9 such packages.
Pharmacodynamics
The active element of the drug is hydrosphere, the chemical properties of which allow it to be classified as flavonoids. It is a standard mixture containing the components of 5,3'mono-O- (β-hydroxyethyl) -diosmin, as well as 5,3'-di-O- (β-hydroxyethyl) -diosmin.
The medicinal effect of hydrosmol has not been fully studied yet, but one can note the presence of an interrelation with the slowing down of catecholamine degradation - mainly due to inhibition of catechol-O-methyltransferase activity. While it has not yet been possible to determine the therapeutic effect of drugs, it is still possible to identify the four basic properties provided by hydrosmin:
- strengthening the strength of the walls of capillaries, the permeability of which can be caused by the action of bradykinin with histamine. Also, the substance prevents capillary fragility, which can develop with an incorrect nutritional regime;
- improvement of hemorheological parameters of erythrocytes, reduction of blood viscosity and increase in the ability of erythrocytes to deform;
- influence in respect of venomotor tonus - gradual stimulation of permanent contractions of muscles of a smooth type in the region of the venous wall;
- creation of optimal conditions for improving the processes of lymphoid circulation. Hydrosmine provokes an expansion of the lymphatic ducts and, together with it, increases the speed of its movement, which improves the lymphatic drainage.
VENOSMIL contributes to the improvement of clinical manifestations of peripheral veins deficiency (feeling of heaviness or pain, as well as puffiness), which is different from the effect of placebo. Undoubtedly, the active element of the drug has a significant effect on the complications of venous stasis, provoked by varicose vascular enlargement in the leg region.
[1]
Pharmacokinetics
After ingestion of a single dose of drugs in a healthy person, a 2-phase character of the plasma plasma time curve with respect to time is noted. The initial Cmax is observed after 15 minutes, and then a slow decrease occurs. After 4 hours after admission, another increase in the drug's values is noted with the achievement of a stable level within 5-8 hours after consumption. Further, the indices inside the plasma decrease. After 24 hours, the substance is almost not observed in the body.
The half-life of the hydrospray is 90% for 48 hours. Excretion of the active element of the drug is mainly carried out by the intestine (80% of the component). With urine, about 16-18% of the portion is excreted on average.
[2]
Dosing and administration
Medication is consumed orally, along with food, while washing with ordinary water.
It is required to prescribe the drug at a dosage of 0.2 g (1 capsule) three times a day (reception at intervals of 8 hours). This treatment cycle should last for 2-3 months.
[4]
Use Venosmila during pregnancy
Clinical tests to determine the possibility of using Venosmila in pregnancy are not available. In pre-clinical trials, a direct or indirect adverse effect on the course of pregnancy, fetal development, as well as the process of labor and postnatal development was not found. Before starting the use of drugs should evaluate the possible benefits and risks of complications from its use.
There is no information on the excretion of the drug with human milk, which is why it should not be used when breastfeeding.
Contraindications
Contraindicated to use in people with intolerance to the elements of the drug.
Side effects Venosmila
Often, therapy is tolerated without complications. Only in people with hypersensitivity can there be negative manifestations. Among the side symptoms developing most often:
- disorders of the digestive function: nausea and stomach pain;
- defeat of the epidermis: itching or rash;
- disorders of the central nervous system: headaches, feelings of weakness and dizziness.
[3]
Storage conditions
The veins should be kept in a place that is closed from small children. The temperature is not higher than 30 ° C.
Shelf life
Venosmil is allowed to be used within 5 years from the date of manufacture of the therapeutic agent.
Attention!
To simplify the perception of information, this instruction for use of the drug "Venosmil" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.