Vabadin 40 mg

Vabadin 40 mg is a hypocholesterolemic drug. The main active ingredient is simvastatin. After taking the drug, it is metabolized in the liver. Thus, it is "converted" into an active form.

The product is intended for people suffering from hypercholesterolemia. In some cases, it is used for secondary prevention of cardiovascular diseases.

Indications Vabadin 40 mg

Indications for the use of Vabadin 40 mg are the use of the drug by patients suffering from hypercholesterolemia. In this case, we are talking about different types of this phenomenon. This can be homozygous or familial hypercholesterolemia. People with mixed dyslipidemia also fall into this category.

The drug is also widely used for secondary prevention of cardiovascular diseases. This mainly concerns those phenomena that were caused by atherosclerosis. The drug is used to treat patients suffering from diabetes. In this case, the person still has elevated or normal cholesterol levels.

The medicine is effective due to the active components in its composition. But if you take it without the doctor's knowledge and prescribe the dose yourself, then all this can result in the development of serious problems. Vabadin 40 is selected individually, much depends on the disease itself and the person's condition.

Release form

The drug is produced only in the form of tablets, this is the main form of release. One blister contains 14 tablets. The packaging is cell, contour. One pack contains two such blisters. Such packaging is convenient, economical and practical.

There is no other form of "packaging". Such data is indicated so that a person does not buy a low-quality product. Today, there is quite a lot of deception, so it is worth giving preference to trusted pharmacies.

Along with two blisters, the package should also contain instructions. This is the main rule, each medicine has a special leaflet, which contains all the information about the medicine.

The drug in tablet form is much more convenient to take, unlike syrup. This form of release is the most optimal. After all, if necessary, the medicine can be taken with you and taken at any convenient time. The drug Vabadin 40 mg is sold only in tablet form, there is no other form of packaging.

Pharmacodynamics

The pharmacodynamics of the drug is that after administration, its active component is immediately hydrolyzed in the liver with the formation of β-hydroxy acid. The drug is taken orally.

The formed enzyme catalyzes the conversion of HMG-CoA into mevalonic acid. It, in turn, is an early and limiting stage of cholesterol biosynthesis. It has been proven that the active component simvastatin is able to reduce the level of LDL cholesterol at elevated and normal levels.

If we talk about LDL, they are formed from VLDL. The process of catabolism occurs by binding to LDL receptors. They have a high affinity for LDL.

The mechanism of LDL level reduction may include LDL-C reduction. Naturally, in many cases, LDL-receptor stimulation is also observed. All this leads to a decrease in production and an increase in catabolzyme.

Therapy with the active substance simvastatin can significantly reduce the level of apolipoprotein B. The level of cholesterol also increases moderately, and the concentration of TG decreases. Ultimately, the ratio of cholesterol to HDL cholesterol decreases. A similar process occurs with LDL cholesterol to HDL cholesterol. Vabadin 40 has remarkable properties due to its leading active component.

Pharmacokinetics

The inactive lactone form of the active substance is hydrolyzed in the liver, this is the pharmacokinetics. Absorption is good. The active component simvastatin is well absorbed and undergoes extensive extraction from the blood during the first passage through the liver.

The level of this process directly depends on the speed of blood flow that enters the liver. This organ is the main site of all action. The available dose of β-hydroxy acid after taking the drug is only 5%. The concentration of active metabolites occurs within 1-2 hours. If a person ate food while taking the drug, this effect will not affect the absorption of the drug. With prolonged use of the drug, cumulation does not occur.

The active component simvastatin binds to plasma proteins by almost 95%. The substance is an isoenzyme substrate. Its main metabolites are also contained in plasma proteins. Vabadin 40 is contained in urine in the amount of 13% and feces, for 96 hours.

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Dosing and administration

The main method of application and doses of Vabadin 40 are the presence of one or more diseases. This process is individual. But, despite this, it is necessary to start from general recommendations.

The drug is used only orally. The tablets must be swallowed whole, without chewing. The daily dose of the drug is usually determined for one dose only. To achieve the maximum therapeutic effect, it is worth taking the drug at night.

If other medications are taken simultaneously with this one, a special interval between uses must be observed. Usually it is at least 2-4 hours. The duration of the course of treatment directly depends on the desired effect and the disease that a person has.

Adults usually take 5 to 80 mg of the drug once a day. There is no need to split the dose into several doses. If the patient has hypercholesterolemia, the initial dose is 10 mg. If necessary, it is increased to 20-40 mg. The maximum a person can take per day is 80 mg.

People suffering from homozygous or familial hypercholesterolemia should take 40 mg of the drug. It is possible to split this dose into two doses of 20 mg. In this case, the drug is taken during the day or at night.

Patients with an increased risk of cardiovascular pathology are prescribed 20-40 mg of the drug as a preventive measure. If necessary, the dose is gradually increased. If you need to take the maximum dose, it is recommended to monitor the level of lipids in the blood, as well as the general condition of the person. After all, Vabadin 40 is a powerful drug that should be taken under the supervision of a physician.

Use Vabadin 40 mg during pregnancy

The use of Vabadin 40 during pregnancy is contraindicated. Before starting therapy with this drug, you need to consult with your doctor. If a woman is just planning to get pregnant and needs to take the drug, then she should wait with childbirth.

During the medication, it is recommended to use more reliable contraception. Because pregnancy should not occur during this period in any way. Otherwise, the development of anomalies and pathologies in the fetus is possible.

If a woman plans to become a mother, then she should stop taking the drug a month before conception. In some cases, the use of the drug is a necessity. This issue is especially acute during lactation. Usually, a decision is made to stop breastfeeding the baby. Because the active components of the drug can penetrate the child's body. You should not do anything on your own. A doctor's consultation is necessary. After all, taking Vabadin 40 can cause serious harm to both the mother's and the child's body.

Contraindications

The main contraindications to the use of Vabadin 40 are the presence of allergic reactions to some components of the drug. Almost every medication requires compliance with certain conditions. In no case should the drug be used with individual hypersensitivity.

The drug should not be used by people with lactase deficiency and galactose intolerance. Severe liver diseases also do not allow resorting to therapy with this medication.

In no case should this drug be combined with CYP3A4 inhibitors. It is also contraindicated during pregnancy and breastfeeding. Persons under 18 years of age are at particular risk. There is currently insufficient data on the use of the drug at this age.

Severe kidney disorders, their functions, alcoholism and diseases of the muscular system are included in the risk group. People suffering from these phenomena are not recommended to use the drug. Vabadin 40 also affects the level of work with dangerous mechanisms and driving a car.

Side effects Vabadin 40 mg

Side effects of Vabadin 40 are not excluded. Thus, during the use of the drug, some patients experienced negative reactions of the body. Moreover, this was observed on the part of many systems and organs.

The gastrointestinal tract can react negatively to taking the drug. This manifests itself in the form of nausea, vomiting, and pain in the epigastric region. Flatulence and problems with stool may develop. Jaundice and hepatitis may occur.

The central and peripheral nervous systems react to the drug in a peculiar way. Severe headache, paresthesia, and dizziness may be observed. In rare cases, peripheral polyneuropathy has developed. Musculoskeletal system: severe muscle pain, myopathy, joint pain, and arthritis.

The hematopoietic system manifests itself in the form of anemia, increased erythrocyte sedimentation rate and eosinophilia. If we take into account laboratory indicators, then an increase in the activity of liver transaminases is possible.

Allergic reactions may also manifest themselves in the form of itching, skin rash, dermatomyositis, Quincke's edema. The occurrence of suffocation, asthenia and increased body temperature is not excluded. In any case, the use of Vabadin 40 should be stopped and seek medical help.

Overdose

Is there an overdose of Vabadin 40? Such cases have occurred, but mainly during the use of the drug in the maximum dose. The human body can react negatively to such an effect.

In many cases, the patients themselves are to blame. Wanting to achieve improvement, they independently increase the dose, and even exceed the maximum threshold. This leads to the development of side effects.

This process has a particularly negative effect on the stomach. It is necessary to immediately wash it out and prescribe the person to take enterosorbents. If the situation is complicated, resort to symptomatic therapy.

It should be understood that taking an increased dose poses a serious danger to human life. This can even lead to death. Therefore, you should never increase the dosage on your own. Moreover, taking the drug is agreed upon with your doctor. You cannot just buy the product and start using it. Vabadin 40 requires clear instructions regarding its use.

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Interactions with other drugs

Interactions with other drugs are possible, but there are still some medications that require special caution. When combined with fibrates and nicotinic acid, cases of increased risk of myopathy and rhabdomyolysis have been noted.

In no case should the drug be combined with CYP3A4 inhibitors. The drug is not recommended to be taken together with gemfibrozil. If this combination is necessary, the daily dose of Vabadin 40 should not exceed 10 mg.

When combining the drug with danazol, cyclosporine and niacin, the dose of the active substance must be adjusted. If we are talking about amiodarone and verapomile, the daily dose of the drug should not exceed 20 mg.

Simultaneous administration of the drug with diltiazem requires a dosage of 40 mg, this is the maximum permissible. During the therapy, it is recommended to drink grapefruit juice. It can reduce the negative impact of the drug on the body. Vabadin 40 should not be taken on its own, especially in combination with other drugs.

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Storage conditions

The main storage conditions for Vabadin 40 are to maintain the temperature regime. Thus, the indicator should not exceed 15-25 degrees Celsius. Any other temperature can negatively affect the "condition" of the tablets.

In addition, you need to provide an ideal storage place. It should not be damp, not exposed to direct sunlight and not cold. These are the optimal conditions that should be followed.

It is important to ensure that children are completely inaccessible to the drug. After all, it can have a serious negative effect on the baby's body. If the use of the drug is dangerous for an adult, then for a child it increases many times over.

You also need to watch the appearance of the packaging itself. If it is damaged, then most likely you should not take the medication. They can lose their positive properties under the influence of negative factors from the outside. Vabadin 40 requires compliance with certain storage conditions, in which case the product will last for more than one year.

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Shelf life

The shelf life of the drug is 3 years. But the number alone is not enough in this case. The shelf life may vary depending on the conditions in which the product is stored. So, if you do not follow the basic rules, you can say goodbye to the medicine in a matter of months.

The main enemy of the drug is dampness and cold. In such conditions, the medicine quickly becomes unusable. Direct sunlight is also an important criterion. It is unacceptable for them to penetrate the packaging. Too high or, on the contrary, low temperatures also have a negative effect on the drug.

It is necessary to monitor the appearance of the tablets. After all, over time, under conditions of improper use, they can change their smell and color. In this case, you can no longer take the drug. Children can also damage the packaging, so the medicine must be protected from them. After all, this can cause harm to both the baby and the adult who will subsequently take the drug. Vabadin 40 is a powerful medicine that requires special treatment.

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