Vabadine 40 mg

Vabadine 40 mg is a hypocholesterolemic drug. The main active ingredient is simvastatin. After taking the drug, it is metabolized in the liver. Thus, it "turns" into an active form.

It is intended for people suffering from hypercholesterolemia. In some cases, it is used for the secondary prevention of cardiovascular diseases. 

Indications Vabadine 40 mg

Indications for use Vabadin 40 mg is the use of the drug in patients suffering from hypercholesterolemia. In this case, we are talking about different varieties of this phenomenon. It can be homozygous or familial hypercholesterolemia. People with mixed dyslipidemia also fall into this category .

The drug is widely used for secondary prevention of cardiovascular diseases. This is mainly true for those phenomena that were caused by atherosclerosis. The medication is used to treat patients with diabetes mellitus. In this case, a person still has an elevated or normal level of cholesterol.

The drug is effective due to the content of active components in its composition. But if you take it without the knowledge of the doctor, and independently prescribe the dose, then all this can turn into the development of serious problems. Vabadin 40 is selected individually, much depends on the disease and the condition of a person.

Release form

The preparation is produced only in the form of tablets, this is the main form of release. One blister contains 14 tablets. Packing is cell, contour. One packet contains two such blisters. This package is convenient, economical and practical.

There is no other form of "packaging". Such data are indicated so that a person does not buy a poor-quality product. To date, quite a lot of fraud, so you should give preference to proven pharmacies.

Along with two blisters in the package there must be an instruction. This is the main rule, each medicine has a special leaflet, which describes all the information about the medicine.

The drug in the form of tablets is much more convenient to take, in contrast to the syrup. This form of release is the most optimal. After all, if necessary, you can take the medicine with you and take it at any convenient time. Medications Vabadine 40 mg is sold only in the form of tablets, there is no other form of packaging.

Pharmacodynamics

Pharmacodynamics of the drug consists in the fact that after taking it, the active ingredient immediately hydrolyzes into the baking with the formation of β-hydroxy acid. Medication takes orally.

The enzyme formed catalyses the conversion of HMG-CoA to mevalonic acid. It, in turn, is an early and limiting stage of biosynthesis of cholesterol. It was proved that the active component of simvastatin is able to lower LDL cholesterol at an elevated and normal level.

If we talk about LDL, they are formed from VLDL. The catabolism process occurs by binding to LDL receptors. They also have a high affinity for LDL.

The mechanism of lowering LDL-C may include lowering LDL cholesterol. Naturally, in many cases, stimulation of LDL receptors is also observed. All this leads to a decrease in production and an increase in catabolzyme.

Therapy with an active substance simvastatin can significantly reduce the level of apolipoprotein B. Moderately increased and the level of cholesterol, and also reduces the concentration of TG. Eventually, the ratio of cholesterol to cholesterol is reduced. A similar process occurs with LDL cholesterol to HDL cholesterol. Vabadine 40 has remarkable properties, thanks to its leading active ingredient.

Pharmacokinetics

The inactive lactone form of the active substance is hydrolyzed in the liver, this is the pharmacokinetics. Absorption is good. The active ingredient simvastatin is perfectly absorbed and extensively extracted from the blood during the first passage through the liver.

The level of this process directly depends on the speed of the blood flow, which enters the liver. This body is the main place of the whole action. The available dose of β-hydroxy acid after taking the drug is only 5%. The concentration of active metabolites occurs within 1-2 hours. If a person took food during the application of the drug, then this action will not affect the absorption of the drug. With prolonged use of the medication, cumulation does not occur.

The active component of simvastatin binds to blood plasma proteins by almost 95%. The substance is a substrate of isoenzyme. Its main metabolites are also contained in the proteins of the blood plasma. Vabadine 40 is present in urine at a rate of 13% and feces, for 96 hours.

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Dosing and administration

The main method of administration and dose of Vabadin 40 are in the presence of one or many diseases. This process is of an individual nature. But, despite this, we need to build on the general recommendations.

The drug is used only orally. Tablets must be swallowed whole, without biting. The daily dose of the drug is mainly determined only by one method. To achieve the maximum therapeutic effect, it is worth taking medication at night.

If other medicines are taken simultaneously with this medication, then a special interval between uses should be observed. Usually it is not less than 2-4 hours. The length of the course of treatment directly depends on the desired effect and the disease that is present in a person.

Adults usually take 5 to 80 mg of the drug once a day. To break a dose into several receptions is not necessary. If the patient has hypercholesterolemia, then the initial dose is 10 mg. If necessary, it increases to 20-40 mg. The maximum for a day a person can take 80 mg.

People suffering from homozygous or familial hypercholesterolemia need to take 40 mg of the drug. It is possible to divide this dose into two doses of 20 mg each. In this case, the remedy is taken during the day or at night.

Patients with an increased risk of cardiovascular pathology as a prophylaxis is prescribed 20-40 mg of the drug. If necessary, the dose gradually increases. If you need to take the maximum dose, it is recommended that you monitor the level of lipids in the blood, as well as the general condition of a person. After all, Vabadin 40 is a powerful remedy that must be taken under the supervision of a doctor.

Use Vabadine 40 mg during pregnancy

Use of Vabadine 40 during pregnancy is contraindicated. Before starting therapy with this medication, you should consult your doctor. If a woman is only going to become pregnant and she needs to take a remedy, then with childbearing it is worth waiting.

It is recommended that more reliable contraception be used during medication. Because pregnancy should not occur during this period in any way. Otherwise, the development of abnormalities and pathologies in the fetus is possible.

If a woman plans to become a mother, then a month before conception is to stop taking the drug. In some cases, the use of a medicine is a necessity. This issue is especially acute during lactation. Usually a decision is made to stop the baby from breastfeeding. Because the active components of the drug can penetrate the child's body. Independently to undertake something it is not necessary. Consultation of the doctor is necessary. After all, taking Vabadin 40 can cause serious harm, both to the mother and the baby.

Contraindications

The main contraindications to the use of Vabadin 40 are the presence of allergic reactions to certain components of the drug. Almost every drug requires certain conditions. Use the product with individual hypersensitivity in no case it is impossible.

The drug can not be used for people with lactase deficiency and intolerance to galactose. Severe liver diseases also do not allow you to resort to therapy with this medication.

In no event should the combination be combined with CYP3A4 inhibitors. During pregnancy and during lactation, it is also contraindicated. The special risk is made by persons who have not reached the age of 18. To date, there is not enough data on the use of the drug at this age.

Severe disorders of the kidneys, their functions, alcoholism and diseases of the muscular system are at risk. People who suffer from these phenomena are not recommended to use the drug. Vabadin 40 also affects the level of work with dangerous mechanisms and driving a car.

Side effects Vabadine 40 mg

Side effects of Vabadin 40 are not excluded. So, during the application of the drug in some patients negative reactions of the organism appeared. And this was observed by many systems and bodies.

The gastrointestinal tract is able to react negatively to taking the drug. This manifests itself in the villa of nausea, vomiting, the presence of pain in the epigastric region. Perhaps the development of flatulence, problems with stool. There may be jaundice and hepatitis.

The central and peripheral nervous systems respond in a peculiar way to the administration of the drug. There may be severe headache, paresthesia, and dizziness. In rare cases, there was a development of peripheral polyneuropathy. Musculoskeletal: severe pain in the muscles, myopathy, pain in the joints and arthritis.

The hematopoiesis system manifests itself in the form of anemia, increasing the rate of erythrocyte sedimentation and eosinophilia. If you take into account the laboratory indicators, it is possible to increase the activity of hepatic transaminases.

Allergic reactions can also manifest themselves in the form of itching, skin rash, dermatomyositis, Quincke's edema. It is possible that choking, asthenia and increased body temperature. In any case, taking Vabadine 40 should be stopped, and ask for help from a doctor.

Overdose

Is there an overdose of Vabadin 40? Such cases have occurred, but mostly during the use of the drug at the maximum dose. The human body can react negatively to such an effect.

In many cases, the patients themselves are to blame. Wanting to achieve improvement, they independently increase the dose, and even exceed the maximum threshold. This leads to the development of side effects.

This process is especially negative for the stomach. It is necessary to immediately make a wash and appoint a person to enterosorbents. If the situation is difficult, resort to symptomatic therapy.

It should be understood that taking an increased dose carries a serious danger to human life. This can even lead to death. Therefore, it is by no means possible to increase dosage independently. Moreover, the preparation is approved by the attending physician. It's just that you can not buy a product and start using it. Vabadin 40 requires clear instructions regarding admission.

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Interactions with other drugs

Interactions with other drugs are possible, but all the same there are medications with which it is necessary to exercise special care. When combined with fibrates and nicotinic acid, there were cases of increased risk of myopathy and rhabdomyolysis.

In no case should you combine the medication with CYP3A4 inhibitors. The drug is not recommended for taking with gemfibrozil. If this combination is necessary, then the daily dose of Vabadine 40 should not exceed 10 mg.

When the drug is combined with danazol, cyclosporin and niacin, the dose of the active substance must be co-curred. If it is a question of amiodarone and verapomile, then the daily dose of the drug should not exceed 20 mg.

Simultaneous administration of the drug together with diltiazem requires a dosage of 40 mg, this is the permissible maximum. It is recommended to drink grapefruit juice during therapy. It can reduce the negative effect of the drug on the body. Vabadine 40 can not be taken alone, especially in combination with other drugs.

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Storage conditions

The main storage conditions for Vabadin 40 are the observance of the temperature regime. So, the indicator should not exceed 15-25 degrees of heat. Any other temperature can negatively say on the "state" of the tablets.

In addition, you need to provide an ideal storage space. It should not have dampness, direct sunlight and cold. These are the most optimal conditions that should be adhered to.

It is important to ensure complete inaccessibility of children to the drug. After all, it can have a serious negative effect on the baby's body. If, for an adult, the use of a medicine is dangerous, then for a child, it increases at times.

It is necessary to observe the appearance of the package itself. If it is damaged, then most likely, you should not take medication. They can lose their positive properties under the influence of negative factors from outside. Vabadin 40 requires certain storage conditions, in which case the product will last for more than one year.

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Shelf life

Shelf life of the drug is 3 years. But only one figure in this case is not enough. The service life may vary depending on the conditions in which the remedy is. So, if you do not follow the basic rules, then you can say goodbye to the medicine in a few months.

The main enemy of the drug is dampness and cold. In such conditions, the medicine quickly deteriorates. An important criterion is also direct sunlight. It is inadmissible that they penetrate to the package. Too high or vice versa, low temperature also adversely affects the preparation.

It is necessary to monitor the appearance of tablets. After all, they can change their smell and color over time under misuse. In this case, you can not take the remedy anymore. Children can also damage the packaging, so the medicine should be protected from them. After all, it can cause harm, both to the kid, and to the adult, who in the future will take the remedy. Vabadin 40 is a powerful medication that requires special treatment.

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