Utibid

The drug Jutibid with the international and chemical name Norfloxacin (encoding ATS J01MA06) refers to the antibacterial substances of the fluoroquinolone pharmacotherapeutic group, effective in the treatment of infections of the genitourinary and gastrointestinal tract.

Indications Utibid

The agent Jutibid is prescribed for infectious and inflammatory processes, provoked by pathogens, to suppress the activity of which is possible with norfloxacin.

Indications for use: Jutibide tablets:

• diseases of the urinary system;
• intestinal infections;
• diseases of the prostate gland;
• with the preventive purpose for the prevention of repeated urinary tract damage;
• in patients with gonorrhea;
• for the treatment of bacterial infections that occur with a decrease in granulocytes against the background of a decrease in leukocytes (granulocytopenia);
• with "traveler's diarrhea" (gastrointestinal disorders caused by microorganisms present in beverages and food).

Drops with norfloxacin are recommended in therapy:

• with various inflammations of the eye mucosa or eyelids (conjunctivitis, blepharitis, etc.);
• ulcerative lesions of the cornea;
• meibomite (inflammatory process of meibomian glands) of an acute nature;
• infectious lesions of the lacrimal sac (dacryocystitis);
• to prevent the propagation of pathogenic flora after getting rid of a foreign body;
• as a result of dysfunction with chemical damage to the eyes;
• before / after the operation period (eye area);
• external and middle otitis acute or chronic type;
• with the purpose of preventing complications after surgical intervention on the ears.

Release form

One tablet of the drug Yutibid contains 400 mg of norfloxacin. Among the additional components: sodium lauryl sulfate, starch, talc, titanium dioxide (E171), magnesium stearate, propylene glycol, polyethylene glycol, diamond blue (E133), ethyl- and hydroxypropylmethylcellulose (Methocel E 5/15 LVP).

Form of issue:

• tablets in a shell (10pcs in a blister pack, the number of which in a carton varies from 1 to 6pcs);
• drops in the eyes / ears.

Pharmacodynamics

Antibacterial agent Utibid is a synthetic broad-spectrum antibiotic. The drug has a pronounced bactericidal activity, destroys DNA-gyrase (an enzyme involved in supercoiling and stability of DNA bacteria).

Pharmacodynamics Yutibid is based on high activity against most known gram-positive and gram-negative bacteria. The spectrum of action of norfloxacin extends to Neisseria gonorrhoeae (gonococcal gonorrhea), not excluding strains producing penicillinase. The drug is used in the treatment of infectious diseases of the urinary tract infection: Klebsiellae, E. Coli, Proteus spp, Enterobacter spp, Pseudomonas aeruginosa and Serratia marcescens. Norfloxacin eliminates the pathogenic flora that causes inflammation of the small intestine (Salmonella, E. Coli, etc.). The antibiotic is ineffective against a number of anaerobic organisms such as: Actinomyces spp, Peptostreptococcus spp, Chlamidia trachomatis, and others.

Clinical effect lasts up to 12 hours.

[1], [2], [3], [4]

Pharmacokinetics

Absorption of tablets Yutibid occurs in the sections of the gastrointestinal tract and amounts to 40%. Parallel eating significantly reduces the absorbent capacity of the drug. Peak concentrations are observed one hour after ingestion. The percentage connection with the plasma protein does not exceed 15%.

Pharmacokinetics Jutibid indicates a good spread of the substance along the cells of the urogenital system, including: ovaries, kidneys, uterus, secretion of the seminiferous ducts, peritoneal and pelvic organs, bile and kidneys. Norfloxacin passes through the blood-brain barrier and placenta, penetrates into the umbilical cord blood, amniotic fluid and mother's milk.

The process of partial metabolism occurs in the liver. The half-life of the antimicrobial substance occurs 3-4 hours after administration. Approximately 30% of the drug in its unchanged form is excreted in the urine (via glomerular filtration and tubular secretion), bile and feces during the day. Excretion from the body is also through metabolic transformation.

Dosing and administration

Utiabid is recommended for patients who have reached the age of 18. The tablet form of the medicine is taken on an empty stomach, washed down with water, or together with a meal. Antibiotics are taken once / twice (morning and evening) per day strictly at the same time. Drops are used as a local drug in ophthalmology and ENT-practice (1-2 drops up to 4 times a day, in especially severe cases, the indicated dosage on the first day is applied every two hours).

The rate of antimicrobial preparation is calculated based on the degree of damage and sensitivity of pathogens. Often, before the start of therapy, the resistance of pathogenic microflora to norfloxacin is checked.

Method of application and dose of the pharmacological substance. Yutibid: Diagnosis Dosage Duration of use cystitis of the acute course (uncomplicated type) 400 mg / twice daily for 2-3 days infection in the urinary tract 400 mg / twice per day week-month recurrences of infection of the urinary system occurring in a chronic form 400 mg / twice a day before 12 weeks (if relief comes in 4 weeks, then you can confine yourself to a pill per day) with a prophylactic goal in detecting gram-negative microorganisms against a background of reduced protection th forces of the body and severe neutropenia 400 mg up to 3 times per day for the period of neutropenia

Typhoid fever 400 mg / thrice a day 2 weeks infection with gonorrhea in acute form (for example, with proctitis, urethritis, pharyngitis, etc.) 800 mg once to avoid "traveler's diarrhea" 400 mg / once a day the day before travel and for a period of , not exceeding 21 days Patients of advanced age, as well as individuals with renal insufficiency, need to individually adjust the rate of the drug Yutibid.

[5]

Use Utibid during pregnancy

It is forbidden to use Utibid during pregnancy and during breastfeeding, as it was found experimentally that norfloxacin provokes arthropathy (trophic joint damage).

Contraindications

The use of the drug Yutibid has a number of features:

• is appointed with subsequent control of the condition to persons prone to epileptic attacks and convulsive syndromes of various etiologies;
• caution is needed in the treatment of patients with liver and kidney dysfunction;
• the drug affects photosensitivity, so patients should avoid prolonged exposure to the sun and visit the solarium;
• In the treatment of elderly people, sometimes there were cases of rupture of the tendon (especially Achilles) or tendinitis, so it is important to consult a doctor in time for the first pain symptoms and inflammation.

Contraindications to the use of Jutibides:

• sensitivity to one of the components of the drug;
• bearing the baby;
• the period of breastfeeding;
• patients under the age of 18;
• congenital anomaly of erythrocytes (deficiency of glucose-6-phosphate dehydrogenase).

Treatment with an antimicrobial agent should take place during the control of diuresis (the patient should consume enough water). If surgical intervention is required, then the blood clotting properties are monitored, since during the treatment with norfloxacin, an increase in the prothrombin index is often observed.

Side effects Utibid

Therapy with antibiotic Yuutibid can be characterized by unpleasant consequences, which include - ringing in the ears, excessive lacrimation, vaginal candidiasis. Clinical practice points to rare cases of pseudomembranous colitis and anaphylaxis in patients taking norfloxacin.

At the time of treatment, the following side effects of Utibide may be identified:

• dysfunction from the side of the central nervous system - different in intensity of head pain, dizziness, the appearance of hallucinations, sleep disturbance;
• digestive organs - bitter taste in the mouth, nausea / vomiting, anorexia, intestinal disorders, enterocolitis, abdominal pain syndrome;
• problems of cardiovascular nature - a pre-memory state or loss of consciousness, vasculitis, lowering of pressure, arrhythmia, tachycardia;
• musculoskeletal disorders - tendonitis, tendon rupture, arthralgia;
• urinary organs - bleeding from the urethra, dysuria dysfunction, formation of salt crystals, kidney disease (glomerulonephritis, hypercreatininaemia);
• allergies - itching, rashes on the skin (eg, urticaria), the appearance of swelling, Stevens-Johnson syndrome;
• hematopoiesis system - quantitative reduction of leukocytes (leukopenia), decrease in hematocrit, eosinophilia.

Overdose

In the event of a deterioration in the general condition of the patient and the detection of one of the listed symptoms, you should seek medical help:

• fever, fever, chills;
• occurrence of shortness of breath;
• allergic manifestations;
• a drop in leukocyte or platelet count (leukopenia / thrombocytopenia);
• disorders of the gastrointestinal nature;
• the appearance of signs of acute hemolytic anemia;
• disturbances in the work of the kidneys.

Overdose of antimicrobial agent UtiBid requires immediate intake of calcium-containing solution. The combination of an antibiotic with calcium significantly reduces the absorption capacity of the drug in the intestine. The patient with complaints is carefully examined and recommended normalizing, supporting therapy, the basis of which is sufficient fluid intake. Particularly difficult situations are resolved by washing the stomach, staying in the hospital under supervision for several days.

Interactions with other drugs

Norfloxacin is an inhibitor of the CYP IA2 enzyme, which determines the ability of an antibiotic to interact with the pharmacological substances that form metabolites based on this enzyme.

Interactions of Jutibides with other drugs:

• there was a decrease in the therapeutic effect with simultaneous administration of Utibide and drugs based on nitrofurantoin;
• theophylline increases the likelihood of side effects of norfloxacin, simultaneous intake of drugs increases the concentration of theophylline in the blood plasma;
• Yutibid has a retarding effect on the processes of dehydration of caffeine, so there is often a reduction in excretion and an increase in the half-life of caffeine from the plasma. This fact should be taken into account when consuming caffeine-containing beverages and pharmacological agents;
• the combination of norfloxacin and cyclosporine is undesirable, while an increase in the quantitative content of the latter substance in the serum is observed;
• Yutibid enhances the anticoagulant properties of warfarin;
• norfloxacin can reduce the effect of hormonal contraceptives, so for the period of treatment should be provided for other methods of preventing unwanted pregnancies;
• studies conducted on animals have shown that fenbufen in parallel with norfloxacin increases the risk of epileptic seizures;
• Antacid drugs and drugs with iron, magnesium, zinc, calcium, aluminum should not be taken together with the antibiotic of the fluoroquinolone group, since they reduce the absorbing activity of the antimicrobial agent (norfloxacin is taken at least two hours before or four hours after the use of such drugs).

[6], [7]

Storage conditions

Conditions of storage: Yutibid - in a cool place, which excludes penetration of sun rays and children. The temperature range should be in the range of 15-25 ° C.

Shelf life

The drug Yutibid has a shelf life of three years from the date of manufacture and subject to the preservation of the integrity of the package.