Upsarin Upsa

A non-steroidal anti-inflammatory drug in a convenient effervescent form – Upsarin Upsa – has the ATC code N02BA01.

Indications Upsarin Upsa

Upsarin Upsa is prescribed in cases of:

• for minor or moderate pain of various origins (headache, toothache, migraine, neuritis, myositis, arthritis and arthrosis, painful menstruation);
• to eliminate discomfort associated with a hangover;
• to normalize temperature readings in cases of acute respiratory infections or acute respiratory viral infections.

Upsarin Upsa can be prescribed to adult patients or children after they reach 15 years of age.

Release form

Non-steroidal drug Upsarin Upsa is an effervescent soluble tablet based on acetylsalicylic acid. The auxiliary components include citric acid crystals, sodium carbonate, bicarbonate and citrate, aspartame, and natural flavoring additive.

The tablets are round and flat, with a dosing notch on one side. The tablets are white.

The drug is dissolved in water. Dissolution is accompanied by intense release of gaseous bubbles.

Upsarin Upsa tablets are packed in aluminum cell-less packages of 4 pcs. in each. A cardboard box can contain 4 or 25 such packages.

Pharmacodynamics

Upsarin Upsa has anti-inflammatory, analgesic and temperature-reducing effects, which is associated with the inhibition of cyclooxygenase, which regulates the production of prostaglandins.

At the same time, platelet aggregation and adhesion are reduced, and the risk of thrombus formation is reduced due to the inhibition of thromboxane A² production within platelets.

Inhibition of thrombus formation continues for one week after a single dose of Upsarin Upsa.

Pharmacokinetics

The kinetic properties of Upsarin Upsa have not been sufficiently studied. When the drug comes into contact with water, a buffer liquid is formed, which after oral administration of the drug retains its active components in the form of a solution, preventing their precipitation and hardening under the action of gastric acid. As a result, complete and rapid absorption of the drug is achieved, which ensures its more effective action compared to standard aspirin tablets.

Dosing and administration

Upsarin Upsa is indicated for use by adult patients and children aged 15 years and older.

The tablets are taken orally, after dissolving in warm water (150-200 ml), 1 tablet up to 6 times a day. Severe pain is relieved by taking two tablets at a time, but even in this case the daily amount of the drug should not exceed six tablets.

For elderly people, the daily dose of the drug is limited to 4 tablets.

The optimal time interval between taking pills is 4-5 hours.

The duration of use of the medication is no more than 5 days (unless the doctor has prescribed otherwise).

Use Upsarin Upsa during pregnancy

The use of Upsarin Upsa should be avoided during pregnancy due to the increased risk of bleeding.

The question of taking the drug during breastfeeding should be decided with a doctor.

Contraindications

Some diseases and conditions may be a contraindication to taking Upsarin Upsa:

• increased likelihood of an allergic reaction to the ingredients of the medication;
• erosions and ulcers in the digestive system, internal bleeding;
• significant disruptions in the functioning of the kidneys and liver;
• acetylsalicylic acid-sensitive asthma;
• diseases accompanied by blood clotting disorders (hemophilia, thrombocytopenia, angioectasia, von Willebrand syndrome);
• aortic aneurysm;
• increased pressure in the portal vein system (portal hypertension);
• vitamin K deficiency;
• phenylketonuria;
• period of pregnancy and breastfeeding.

It is not recommended to take Upsarin Upsa in case of gout and decompensation of cardiac activity.

Side effects Upsarin Upsa

Side effects are rare, but may include the following symptoms:

• allergic reactions;
• aspirin triad (bronchial asthma, nasal polyposis and hypersensitivity to aspirin and pyrazolone derivatives);
• dyspeptic disorders, internal bleeding, loss of appetite, increased activity of liver transaminases;
• renal dysfunction;
• anemia, leukopenia;
• bleeding of the mucous membrane of the nose and mouth.

If any of the listed symptoms appear during treatment with the drug, then you should stop taking the tablets and consult a doctor.

Overdose

Signs of an overdose of Upsarin Upsa may include CNS excitation, headache, dizziness, deterioration of hearing and vision, nausea, and increased respiratory rate. In severe cases, there is a disorder of consciousness up to a comatose state, difficulty breathing, and dehydration.

If the patient has such symptoms, then in this case it is recommended to wash the stomach (or induce profuse vomiting), removing the remains of the drug from the digestive system, and then take a sorbent and a laxative. Further treatment is carried out by a doctor in a hospital.

Interactions with other drugs

Upsarin Upsa may enhance the toxic effects of:

• methotrexate;
• narcotic painkillers;
• other non-steroidal drugs;
• internal hypoglycemic agents;
• heparin-based medications;
• indirect anticoagulants;
• sulfonamide drugs;
• blood pressure lowering agents;
• diuretics;
• thrombolytic enzymes;
• triiodothyronine.

Concomitant use of Upsarin Upsa with glucocorticosteroid drugs or alcoholic beverages increases the risk of damage to the mucous membranes of the stomach and other parts of the digestive tract.

Combination with antacids based on magnesium or aluminum makes it difficult to absorb Upsarin Upsa.

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Storage conditions

Store packaged tablets at room temperature, out of reach of children and out of direct light.

Shelf life

The shelf life of Upsarin Upsa is up to 3 years.

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