Unicpec

The drug Unikpef - refers to the antibacterial medications of the fluoroquinolone group.

Indications Unicpec

 Unikpep is used for the treatment of infectious pathologies, the causative agents of which are sensitive to the action of this drug:

• infectious diseases of the urinary, digestive system, liver and biliary system;
• infectious diseases of reproductive organs, musculoskeletal and respiratory system, otolaryngological and ophthalmologic inflammatory processes;
• intra-abdominal abscesses;
• inflammation of the abdominal cavity (peritonitis);
• septic states and septicemia;
• inflammatory processes in the heart tissues;
• meningitis and encephalitis;
• osteomyelitis;
• infection of the genital area;
• post-surgical and nosocomial infections;
• as prevention of infectious pathologies and consequences.

Release form

Unicape is a tablet with film coating, light color, capsule-shaped, with a one-sided notching for convenient dosage.

The active component of Unicopef is pefloxacin mesylate dihydrate.

Additional components are represented by corn starch, MCC, carboxymethyl starch, silicon dioxide, magnesium stearate, dye, talc.

Tablets in the amount of 10 pieces are sealed in a blister. A cardboard package can contain two or ten blisters (which corresponds to 20 or 100 tablets). 

Pharmacodynamics

Unikpep refers to fluoroquinolone antibacterial agents. Accordingly, it is a bactericidal preparation, inhibits the action of bacterial DNA-gyrase, inhibits RNA and the production of microbial proteins.

Effects on gram (-) microorganisms in the phase of division or calmness, as well as gram (+) microorganisms in the division stage. The active ingredient exhibits activity directed against aerobic microbes, as well as against bacteria resistant to other antimicrobial agents.

Unicpeff works:

• on the pathogen of aeromonosis;
• Campylobacteria;
• cytobacteria;
• enterobacteria;
• esherichia;
• hemophilus;
• Klebsiella;
• legionella;
• moraxelles;
• morganella;
• Neisseria;
• pasturella;
• Proteus;
• Providency;
• salmonella;
• shigella;
• serraty;
• staphylococci;
• ureaplasma;
• iersinia.

 Less sensitive pseudomonas, clostridia, chlamydia, mycoplasma. Resistant to the action of the drug gram (-) anaerobes, pale treponema, tuberculous mycobacteria. 

Pharmacokinetics

Absorption of the drug is good enough: after 20 minutes after oral intake of a single amount of Uniciphe absorption is exposed to 90%.

The maximum amount of active component in the blood is detected after 90-120 minutes. The curative content of Unicpecif is determined over a period of 12 to 15 hours.

If Unicipf entered the body many times, then its maximum amount in the serum can be 10 μg / ml, in bronchial secretion - 5 μg / ml, and the ratio of the amount of the drug in the mucosa and the blood flow is 100%.

The binding with plasma proteins is from 25 to 30%.

The active ingredient unhindered enters the liquid media and tissues, including bones, cerebrospinal fluid, prostate, pulmonary tissue. The content in the liquor after three doses of the drug in a standard dose is 4.5 mcg / ml, in an overestimated dose - 9.8 mcg / ml. The quantity in the blood serum and CSF correlates as 89%.

Content 12 hours after using Uniciphe:

• in the thyroid gland - 11.4 μg / g;
• in the salivary fluid, 2.2 μg / g;
• in the skin - 7.6 μg / g;
• in the nasopharyngeal mucosa - 6 mcg / g;
• in pharyngeal tonsils - 9 mcg / g;
• in the muscle tissue - 5.6 mcg / g.

Metabolism occurs in the liver. The main metabolite is dimethylphefloxacin, which is subsequently oxidized with the formation of pefloxacin lucuronide.

Half-life is from 8 to 10 hours, with repeated exposure to the body - from 12 to 13 hours. Excretion is carried out by 60% through the urinary system, 30% by the liver.

The amount of unchanged drug in the urinary fluid 60-100 minutes after admission can be 25 μg / ml, and after a day - up to 15 mg / ml.

The invariable active component and its metabolic products can be detected in the urinary fluid for 84 hours after the end of treatment with the drug.

Hemodialysis practically does not lend itself.

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Dosing and administration

The drug is used for internal reception, be sure to eat.

The dosage and the regimen are determined individually - this may depend on the specific disease and the complexity of the course of the infectious process, as well as the type of pathogen and its sensitivity to the medication.

With an infectious disease without complications, usually take 0.4 g of medicament twice a day. The average Uniciphe number per day is 0.8 g for 2 times. The tablet should be swallowed without chewing or grinding, with enough liquid.

Patients with functional disorders of the liver should adjust the dosage:

• with small disorders take 400 mg per day;
• with disorders of moderate severity take 400 mg once every 36 hours;
• In severe disorders, 400 mg Unicipf is prescribed once every 48 hours.

The duration of the course of therapy is not more than one month.

In the case of a disorder of renal function (creatinine clearance less than 20 ml per minute), one-half of the average Unicleph amount is taken at a time.

Elderly patients are reduced by about a third.

Use Unicpec during pregnancy

Uniciph is not prescribed for pregnant and lactating women, since there is a danger of the future child's erosive damage to cartilaginous tissues.

Contraindications

• Epileptic seizures;
• hemolytic anemia;
• a deficiency state of glucose-6-phosphate dehydrogenase;
• the period of gestation and feeding of the child;
• propensity to allergy to the ingredients of the drug;
• It is not used in pediatrics (only from the age of 18).

 Also, there are certain conditions in which Unicipf is possible, but only under the constant supervision of a doctor:

• atherosclerotic changes in the vessels of the brain;
• disorder of cerebral circulation;
• convulsions, unspecified;
• severe liver and kidney damage.

Side effects Unicpec

 In most cases, Uniciphe is transferred without additional unwanted symptoms. However, sometimes they do occur:

• morbidity in the epigastrium, increased gas formation, attacks of nausea and vomiting, diarrhea, colitis, jaundice, liver damage;
• upset urination;
• sleep disorders, headaches, apathy or nervousness, depressive state, trembling in the muscles of the hands and feet, convulsions;
• Muscle pain, joint pain, inflammation of blood vessels (with intravascular injections);
• a blood test: a decrease in the number of leukocytes, platelets, an increase in the level of eosinophils;
• manifestations of allergies (skin rashes, itching, redness, swelling);
• increased heart rate;
• fungal lesions (candida). 

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Overdose

Signs of an overdose represent an increase in adverse events. In more severe cases, confusion, convulsive syndrome is possible.

Treatment consists in washing the stomach, taking sorbents (activated carbon, enterosgel). Symptomatic drugs may be prescribed.

A special agent that neutralizes the effects of pefloxacin does not exist.

Procedures for hemodialysis and peritoneal dialysis are practically ineffective.

Interactions with other drugs

The active ingredient of the drug works simultaneously with beta-lactam antimicrobials. Unikpep is prescribed in combination with metronidazole and vancomycin.

The combination with rifampicin gives a greater effect against staphylococcal infection. The same can be said about the joint appointment with aminoglycosides, ceftazidine - such treatment mutually enhances the antimicrobial effect of drugs.

The active ingredient raises the level of theophylline in the blood serum and the central nervous system, so when combined with these drugs, the dosage of theophylline is usually adjusted to avoid overdose and the development of adverse events.

In complex use with tetracycline or chloramphenicol, Unicopef has the opposite effect.

In combination with indirect anticoagulants, Unicopeph can provoke a decrease in the prothrombin index.

Uniciphe is incompatible with medicines containing heparin.

If urinalysis is performed against the background of drug treatment, then methods should be used without the use of copper sulfate reagent, since in this case an erroneous result is possible. 

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Storage conditions

The drug is stored in the original packaging, under temperature conditions no more than + 30 ° C. In no case should the drug be frozen.

Keep out of the reach of children's antics.

Shelf life

Shelf life - up to 3 years, after which the drug is prohibited.

The drug Unicopef is allowed to leave in pharmacies only on the prescription of a doctor.