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Ugricil
Last reviewed: 23.04.2024
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Ugricil (synonyms - Dalatsin T, Klindatop) is included in the pharmacotherapeutic group of antimicrobial dermatological preparations.
Indications Ugricil
The drug is prescribed by dermatologists for acne skin diseases (acne) - multiple skin rashes caused by excessive sebum, a decrease in its bactericidal protection and the development of focal inflammation of the skin (due to the multiplication of microbes and bacteria).
Release form
Form release - 1% gel for topical application (in tubes of 15 or 30 grams).
Pharmacodynamics
The active substance of the drug Ugricil - an antibiotic clindamycin (clindamycin) is a semisynthetic analog of lincomycin. Binding to the structures of the matrix RNA of ribosomes of bacteria (nucleotide subunit 23S), clindamycin inhibits the formation of proteins in the cells of the aerobic Gram-positive cocci Staphylococcus aur., Staphylococcus epid., Streptococcus spp., As well as anaerobic gram-positive bacteria Propionibacterium acnes, Eubacterium, Actinomyces spp. And etc.
As a result, bacteria and cocci die (bactericidal effect) or reduce the growth activity (bacteriostatic effect), which depends not only on the specific type of pathogens, but also on the dose of the drug.
In addition, the use of Ugricil significantly reduces the amount of sebum, which helps to cleanse the skin of acne. Obviously, the effect of the antibiotic is enhanced by the antiseptic properties of the preservative of nipagin (methyl ester of para-hydroxybenzoic acid), which is part of this drug as an auxiliary.
Pharmacokinetics
When applied to the skin of the gel, the Ugricil antibiotic accumulates in the sebaceous horny plugs in the ducts of the sebaceous glands (comedones). It is possible that the gel is absorbed by the skin. Bioavailability of clindamycin is about 3%, but this is quite enough to suppress the main causative agent of the acne - anaerobic gram-positive bacterium Propionibacterium asnes.
Dosing and administration
Gel Ugricil it is necessary to put on sites of a skin with rashes: no more than 1-2 g at once, twice a day. The skin must be clean and dry. Avoid contact with eyes and mucous membranes. The duration of the application is determined by the doctor.
Use Ugricil during pregnancy
Given the lack of research on the use of this drug by pregnant women, the use of Ugritsil during pregnancy, as well as during breastfeeding is possible only under strict medical conditions and under the supervision of the attending physician. And when using Ugricil during lactation, breast-feeding should be stopped.
Contraindications
This drug has the following contraindications: age to 12 years; Individual increased susceptibility to antibiotics clindamycin and lincomycin; inflammation of the mucous membrane of the large intestine (ulcerative colitis); presence in the anamnesis of a colitis connected with reception of antibiotics.
Side effects Ugricil
As a possible side effect of this drug, there is an appearance on the site of application of skin irritation, redness, burning sensations and itching, as well as dryness of skin areas and their peeling.
[1]
Overdose
Despite the local application of the gel, its overdose can lead to problems with the intestines - colitis and diarrhea. In this situation, the use of Ugricil should be discontinued.
Interactions with other drugs
Clindamycin in the gel Ugricil has an interaction with other drugs, namely: incompatible with erythromycin, ampicillin, sedatives of the barbiturate group, with calcium gluconate, magnesium sulfate and solutions of B vitamins; is able to enhance the effect of medications-muscle relaxants and opioid analgesics.
It is not recommended to use Ugritsil concomitantly with taking medicines against diarrhea, as this can lead to a disruption of normal intestinal motility.
[2]
Storage conditions
Storage conditions Ugricil - at a temperature of + 15-25 ° C.
Shelf life
Shelf-life is 24 months.
Attention!
To simplify the perception of information, this instruction for use of the drug "Ugricil" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.