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Tsepim is an antibacterial agent that belongs to the fourth generation of cephalosporin antibiotics. ATX code is J01D E01. Manufacturer - Alembic Pharmaceuticals Ltd (India)

Other trade names: Cefepime hydrochloride, Cefepime, Cefomax, Cefepime, Ladef, Maxipim, Etipim.


J01DE01 Cefepime

Indications of tsepim

The drug is applied chainsWe polirezistetnyh in severe infections affecting the respiratory, urinary and digestive system, liver, kidneys, pelvic organs, skin, soft tissues, bones and joints. Use of a preparation effective for extensive abscess, bacterial meningitis, peritonitis, sepsis.

Due to the high activity against Pseudomonas aeruginosa in testimony chainsWe also includes premedication major surgery to prevent postoperative suppurative complications.

Release form

Sterile powder in vials for the preparation of an injection solution.


Tsepim has a bactericidal action against most aerobic β-lactam Gram-positive cocci and Gram-negative bacteria, as well as non-fermenting and chromosomal microorganisms, anaerobic bacteria and bacteroids.

The active substance of the preparation cefepime hydrochloride, binding to the enzyme of bacterial cell walls (transpeptidase), inactivates its participation in the synthesis of peptides of cytoplasmic membranes, which leads to stopping the division of cells of microorganisms and their lysis.


After parenteral administration, Tsepim enters all body fluids, binding to plasma proteins does not exceed 19%; the average therapeutic concentration in plasma is noted 12 hours after the drug is administered; bioavailability is 100%.

There is no cumulative effect, biological fluids and tissues are cleared of the active substance at an average rate of 120 ml per minute.

Biotransformation of about 85% of Tsepima occurs partly in the liver with the formation of inactive metabolites. The half-life period is approximately two hours.

Metabolites and unchanged cefepime hydrochloride are excreted by renal filtration with urine.

Use of tsepim during pregnancy

Use during pregnancy is permissible only on indications and under the supervision of a doctor. The use of this drug during lactation requires caution.


Tsepim is contraindicated with hypersensitivity to antibiotics-cephalosporins and penicillins, as well as children of the first two months of life.

Side effects of tsepim

Application chainsWe may cause side effects, which appear urticaria; hyperhidrosis; headache; weakness; sleep disorders; numbness and cramps; increased heart rate and shortness of breath; cough or sore throat; decrease the level of white blood cells, red blood cells and platelets in the blood.

May cause indigestion; abdominal pain; diarrhea or constipation; disorders of the kidney and enhance hepatic enzymes. Furthermore, it may be the development of superinfection.

Dosing and administration

Tsepim is administered mainly intravenously (slowly), deep intramuscular injection is practiced in cases of infectious diseases of the urinary tract and pelvic organs.

The standard single dose for adults and children over 40 kg weighs, depending on the severity of the condition, from 500 mg to 2 g. Injections are given every 8-12 hours, which is also determined depending on the severity of the inflammatory process. The minimum duration of the use of Tsepim is 7 days, but if necessary, treatment can be carried out for a longer time.

The dose for the use of this drug for children weighing less than 40 kg is determined from the calculation of 50 mg per kilogram.

For parenteral administration, the dose of Tepim should be dissolved in 10 ml of sterile water for injection, in a 5% solution of glucose or 0.9% solution of sodium chloride.


An overdose of the drug can lead to various encephalopathic manifestations, including, loss of consciousness, stupor, convulsions, coma. Treatment of overdose is carried out by hemodialysis

Interactions with other drugs

Chains should not be confused with other drugs in the same syringe. Combined use of Tsepim and antibiotics of the group of aminoglycosides or loop diuretics increases the risk of toxic effects on the kidneys and a greater likelihood of development of auditory nerve nephritis.

Storage conditions

We chain in the form of a powder in a hermetically sealed vial should be stored at a temperature of + 18-25 ° C; a ready solution can be stored for a day at a similar temperature or up to seven days in a refrigerator.

Shelf life

24 months.

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To simplify the perception of information, this instruction for use of the drug "Tsepim" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

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