Tsebopim

Tsebopim is a universal medicinal product having a wide spectrum of action. Let's consider the indications for the use of this antibiotic, the methods of application, contraindications and side effects.

Tsepopim is used for infectious diseases of the respiratory tract (pneumonia, bronchitis). Also, the drug is effective in treating diseases of the genitourinary system and infections in the urinary tract. In addition, cebopim is used to treat a number of gynecological problems, skin and soft tissue diseases. The drug is a solution for intravenous and intramuscular injections.

Indications Tsebopim

The main indications for the use of cebopim are associated with the antibacterial action of the drug. The drug refers to beta-lactam antibiotics, 4-generation cephalosporins. So, the main indications for the use of tsebopim:

Adult patients:

• Infectious diseases of the respiratory tract ( acute tonsillitis, chronic tonsillitis, acute sinusitis, chronic sinusitis, pharyngitis, chronic rhinitis ).
• Diseases of subcutaneous tissue and skin ( pyoderma, pyoderma, furuncles, impetigo ).
• Pasteuresis (septicemia).
• Diseases of gynecological nature ( salpingitis, cystitis, urethritis ).
• Infectious diseases of the biliary tract ( cholangitis, cholecystitis ).
• Empirical therapy of neutropenic fever.
• Intraabdominal infections ( peritonitis ).
• Preventative procedures for complications in surgery (intra-abdominal).
• Osteomyelitis.

Children and adolescents:

• Infectious diseases of the skin and subcutaneous tissue.
• Pneumonia and other diseases of the respiratory tract ( acute bronchitis, acute and chronic laryngitis ).
• Meningitis.
• Septicemia.

The drug has a strong antibacterial effect, so before taking it, the doctor evaluates all possible risks to the body.

Release form

The form of the preparation is powder for the preparation of intravenous injections. The active substance tsebopim - dihydrochloride monohydrate cebopim, auxiliary substances of the drug - L-arginine.

The drug is available in various volumes. There are vials of 1 and 2 g, in each package there are five vials of the drug. For injections use syringes of suitable volume, that is three or two component ones. The drug is dispensed only by prescription of the treating doctor.

Pharmacodynamics

Pharmacodynamics cebopim acts on the body through inhibition of bacterial synthesis. The drug has a wide spectrum of action, relative to gram-positive and negative bacteria. The drug quickly penetrates into bacterial cells due to its high resistance to the hydrolysis of beta-lactamases. Tsebopim has an effect on:

Gram-positive aerobes

• Staphylococcus epidermidis.
• Streptococcus pneumoniae.
• Staphylococcus aureus and others.

Gram-negative aerobes:

• Proteus sp.
• Gardnerella vaginalis.
• Pseudomonas sp.
• Hafnia alvei.
• Morganella morganii and others.

Anaerobes:

• Veillonella sp.
• Bacteroides sp.
• Peptostreptococcus sp.
• Mobiluncus sp.

Pharmacokinetics

The pharmacokinetics of tsebopim are the processes of assimilation and distribution of the active substance of the drug throughout the body. The drug is perfectly distributed throughout the body and is localized in peritoneal fluid, sputum, gall bladder, urine and bile. The half-life of cebopim is 2-3 hours. In patients without complications, cumulation of the drug does not occur.

The drug is excreted in the urine, that is, thanks to the work of the kidneys. With urine, about 85% of the substance departs, depending on the dose used. Linking to plasma proteins, the drug does not concentrate in the blood serum and its volume does not exceed 15-19%.

Dosing and administration

The method of administration and dose of the drug is prescribed by a doctor, but before taking the drug each patient is given a skin test for the tolerability of the antibiotic. As a rule, the drug is administered intramuscularly every 12 hours. Treatment can be from 10 to 12 days, and in severe infections and up to 24 days.

Recommendations for the use of cebopime for adult patients:

• Urinary tract infections - every 12 hours per day (500 mg) intravenously or intramuscularly.
• Infectious diseases of medium gravity - every 12 hours for 1 g intravenously or intramuscularly.
• Severe infectious diseases (including diseases that threaten life) - every 8-12 hours for 2g intravenously.

Recommendations for the use of the drug tsebopim for children:

• When prescribing the drug for children aged 1 to 2 months, inject every 8-12 hours at 30 mg / kg body weight.
• When giving tsebopim to children from two months, inject every 12 hours at 50 mg / kg.
• The dose of the drug for children weighing 40 kg and more is the same as for adults.

[3], [4]

Use Tsebopim during pregnancy

The use of tsebopim during pregnancy is not recommended. Although studies on the effect of the drug on fetal development and pregnancy in general have not been conducted. During pregnancy, the drug is prescribed only if the benefit to the mother is much more important than the potential risks for the baby's future.

The drug is not allowed during lactation. Since tsebopim in a small amount falls into the breast milk, and therefore penetrates into the unprotected body of the baby. Children are allowed to take the drug from the first month of life and only with the permission and recommendations of the doctor.

Contraindications

The main contraindications to the use of cebopim are individual intolerance of the drug and active substances in its composition. Before using cebopim, the patient is asked about the presence of allergic reactions or hypersensitivity to this antibacterial drug.

Before taking cebepime by patients with a high risk of developing serious infectious diseases, complex antimicrobial therapy is performed. Contraindications for the use of the drug include problems with the gastrointestinal tract, since cebopim can cause severe diarrhea and pseudomembranous colitis. Admission of the drug does not affect the rate of reactions when working with mechanisms or driving vehicles.

Side effects Tsebopim

Side effects of cebepim are extremely rare and, as a rule, in cases of hypersensitivity of the patient to the drug or an incorrectly prescribed dose. Let's look at the most common adverse reactions to taking cebopim.

Problems with the gastrointestinal tract:

• Nausea and vomiting
• Constipation
• Pseudomembranous colitis

Central nervous system:

• Dizziness
• Headache
• Confusion and insomnia

Allergic reactions:

• Anaphylactic reactions
• Itching
• Temperature increase
• Skin dermatitis

Others:

• Chest pain
• Cough and shortness of breath
• Back pain
• Increased sweating
• Inflammation at the injection site
• Vaginitis
• Convulsions
• Peripheral puffiness

[1], [2]

Overdose

Overdose of cebepim occurs in case of non-compliance with the prescribed time of drug administration or exceeding the course of treatment. When an overdose of the drug, the patient may experience impairment of consciousness, encephalopathy, coma, convulsive reaction, stupor and even epileptic seizure.

To get rid of an overdose, you must stop using the drug and conduct symptomatic therapy. In case of severe allergic reactions and overdoses, intensive therapy with adrenaline is used. But most often with an overdose of cebopim, use hemodialysis.

Interactions with other drugs

The interaction of cebepime with other drugs is allowed only on the advice and permission of the treating doctor. The drug interacts with such drugs as:

• 5% or 10% glucose solutions
• 0.9% solution of sodium chloride
• sodium lactate solution for injection
• 5% dextrose solution for injection.

To avoid adverse reactions, the administration of cebopim is not carried out simultaneously with the use of other antibacterial drugs and lactam antibiotics. Also, cebopim is not used with solutions of vancomycin, netilmicin sulfate, metronidazole. If treatment involves the use of cebepim with the above solutions, then all drugs are administered separately.

[5], [6], [7]

Storage conditions

The storage conditions of tsebopim involve the storage of the drug in a dark, cool place, which is protected from sunlight. Storage temperature should not exceed 30 ° C.

Drug solutions, which are prepared in advance for intravenous and intramuscular injections, are stable for 24 hours, that is, 24 hours. If stored at room temperature. If the drug is stored at a temperature of 2-8 ° C, then it can be used for 7 days.

[8], [9]

Shelf life

The shelf life of tsebopim is three years from the production date, which is indicated on the package. At the expiration date of the drug, it must be disposed of. Not allowed to use tsebopim, the storage of which were mistakes, that is, the temperature regime was not observed. If the drug has changed color, or has acquired an unpleasant smell, it must also be disposed of. When using cebopim after the expiry date, uncontrollable adverse reactions are possible that are pathological and can lead to death.

[10]