Cebrilizine

Nootropic drug Cebrilizin on pharmacological properties and composition is close to cerebrolysin.

Indications Cebrilizine

Indications for the use of cebrilizine are:

• lack of blood circulation of the brain (various variants of the course of discirculatory encephalopathy );
• acute development of cerebrovascular accident ( stroke and post-stroke state );
• trauma to the head, craniocerebral trauma ( brain concussion ), surgical operations in the brain;
• delay in mental development of children;
• acquired dementia, progressive decline in mental abilities, degradation of thinking, memory, behavior;
• Depressive suppressed states, resistant to treatment with psychotropic drugs.

[1], [2]

Release form

Cebrilysin is a liquid for intramuscular injection. Ampoule of 1 ml, in plastic cell packaging, 1 or 2 packs per one cardboard box. Available in the amount of 5 or 10 ampoules in a box.

The active substance of the medication is hydrolyzed in the brain of animals, which has an amino acid and peptide composition. An auxiliary preservative is phenol.

[3]

Pharmacodynamics

Zebrilizine is a nootropic peptide origin, exhibiting neurotrophic activity, which resembles the effect of natural neuronal development factors.

The drug contains a concentrated substance from the brain structures of large horned animals, which is represented by a complex of levorotatory amino acids and low molecular weight bioactive neuropeptides that are in a state of natural balance.

Due to the low molecular weight, peptides freely penetrate the encephalitic barrier and directly go to the neurons of the brain.

The active substance Cebrilysin is able to increase aerobic energy metabolism, improve intracellular production of proteins in both growing and aging brain. In addition, the preparation prevents the formation of independent radical particles, reduces the amount of residual product from fat oxidation processes, increases the survival rate of nerve cells in conditions of lack of oxygen and nutrients, neutralizes neuronal damage by amino acids and lactate, activates the creation of synapses.

[4], [5], [6], [7], [8],

Pharmacokinetics

The drug has a rather complex chemical and biological composition. Its active link consists of a balanced and stable complex of bioactive low molecular weight regulatory oligopeptides that are capable of providing a combined multifunctional effect. Based on this, it is not possible to analyze the pharmacokinetic properties of each component of Cebrilysin.

[9], [10], [11], [12],

Dosing and administration

The drug is intended for intramuscular injection. At the discretion of the doctor, injections are carried out 1 time every 24 or 48 hours, 1 to 5 ml.

The duration of the therapeutic course is about 1 month, with the possibility of a repeat course after 3-6 months.

As a rule, the dosage and duration of therapy depend on the course and complexity of the pathology. An age of the patient is also important.

To achieve the best result, it is recommended that repeated treatment courses be prescribed until a stable positive result of treatment is established. After passing one therapeutic course, the frequency of administration of the drug in a subsequent course can be reduced to 1 injection in 48-72 hours.

[15], [16]

Use Cebrilizine during pregnancy

The use of cebrilysin during pregnancy and during lactation is possible only if the expected beneficial effect for the future (or nursing) mother is much higher than the possible danger to the future (or breastfeeding) child.

The few data obtained empirically do not indicate a teratogenic or toxic effect of the active substances of the drug on the embryo. But it should be remembered that special clinical trials on this issue have not been conducted.

If we take into account the above, we can draw the following conclusions:

• if possible, it is better to stop using cebrilysin during pregnancy and lactation;
• if the drug is unavoidable, then his appointment is very cautious, and only in the second half of pregnancy;
• when taking the drug during breastfeeding, it is recommended to stop feeding.

Contraindications

Contraindications to the use of cebrilysin may be as follows:

• propensity to allergy to certain components of the drug;
• failure of renal function;
• propensity to convulsive attacks, epilepsy;
• pregnancy, the first half.

[13], [14]

Side effects Cebrilizine

With a sloppy and very rapid infusion of the drug, a feeling of heat may occur, sweating may increase, the head may turn. Sometimes there is a rapid or irregular heartbeat.

In patients who are hypersensitive to certain medicines, an allergic reaction may develop, which manifests itself in reddening of the skin, rashes, fever and a state of collapse.

At the site of administration, a burning sensation and redness may appear.

Sometimes development of dyspeptic disorders is possible: attacks of nausea, diarrhea or constipation.

Less often, the drug can cause sleep disorders, irritability, convulsive muscle contractions of the limbs.

Overdose

Cases of drug overdose Cebrilizin were not recorded. We can assume an increase in side effects in case of an overdose. Treatment - the drug cancellation, carry out measures to detoxify the body.

[17], [18]

Interactions with other drugs

Increased activity of each other is possible with the joint use of Cebrilizine with antidepressants and agents that inhibit monoamine oxidase (Selegiline, Eldepril, Yumeks, etc.). If joint use is not avoided, it is recommended to lower the dosage of antidepressant.

Cebrilysin can not be combined in one introduction with lipid solutions, as well as with substances capable of altering the ph environment (from 5.0 to 8.0).

[19], [20], [21], [22], [23]

Storage conditions

The drug is stored in a dark place. The optimal temperature for preserving the medication is + 18-20 ° C.

[24],

Shelf life

Shelf life - up to 3 years.

[25]