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Treatment of giardiasis with nemozole: schemes, analogs
Last reviewed: 03.07.2025
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To effectively combat intestinal parasites such as Giardia lamblia (or Lamblia intestinalis), it is necessary to use anthelmintic drugs. In particular, Nemozol is widely used for giardiasis.
This antiparasitic drug belongs to the group of benzimidazoles, ATX code – P02CA03; it is produced by the Indian pharmaceutical company Inca Laboratories, which has FDA and MHRA certificates.
Other trade names (synonyms) of Nemozole: Albendazole, Aldazole, Gelmadol, Zentel.
Indications Nemozole for giardiasis
In addition to giardiasis in adults and children, Nemozol is used to treat infestations with nematodes, cestodes and trematodes, which cause ascariasis, trichinosis, ancylostomiasis, enterobiasis, opisthorchiasis, taeniasis and other parasitic diseases.
This drug is used in the treatment of mixed helminthiasis, as well as in cases of tissue parasitic cysts formed by echinococci, and neurocysticercosis developing when the central nervous system is affected by pork tapeworm larvae.
Release form
Nemozol is available in tablet form (0.4 g tablets) and in suspension form (packaged in 20 ml bottles).
Pharmacodynamics
The pharmacological action of Nemozol is provided by the anthelmintic compound benzimidazole carbamate (albendazole), which irreversibly disrupts glycogen metabolism in adult diplomonad protozoa Giardia lamblia (as well as in nematodes and cestodes), preventing glucose absorption. The drug has a detrimental effect on the cells and mitosomes of lamblia, as it reduces to a critical level the production of protein components that form the cytoskeleton of their intestinal tract. And inhibition of ATP production leads to inhibition of all life-supporting processes and prevents the formation of fertilized eggs.
Pharmacokinetics
Due to the poor solubility of albendazole, after taking Nemozol orally, no more than 5% of the active substance enters the bloodstream from the gastrointestinal tract. However, eating food containing a lot of fat can increase the absorption of the drug fivefold.
Albendazole binding to plasma proteins is approximately 70%. A significant portion of the drug enters the gallbladder, liver, and cerebrospinal fluid.
The half-life of benzimidazole carbamate in the liver to primary active metabolites lasts 8.5 hours, after which biotransformation by oxidation continues - with the formation of secondary (inactive) metabolites in the form of sulfur-containing compounds of albendazole. The breakdown products and part of Nemozol in its original form are excreted by the intestines and kidneys - with bile enzymes, feces and urine; T1 / 2 - from 8 to 12 hours.
Dosing and administration
How to take Nemozol for giardiasis? In the form of tablets (0.4 g) Nemozol for giardiasis in adults should be taken orally whole (during or immediately after meals) - one tablet once a day. The dosage for children is determined based on the calculation: 6 mg per kilogram of body weight.
How many days to drink Nemozol for giardiasis? The standard course of treatment is five days
Nemozol suspension for giardiasis in children is taken 10 ml once a day, also for five days. For adults and children over 12 years old, the dose of the suspension is 20 ml.
Use Nemozole for giardiasis during pregnancy
Use during pregnancy is contraindicated.
Contraindications
Not everyone can use Nemozol for giardiasis. Contraindications to this drug include: increased individual sensitivity to albendazole, chronic liver failure and cirrhosis, suppression of hematopoietic functions of the bone marrow, severe leukopenia, retinal pathologies, children under two years of age.
Side effects Nemozole for giardiasis
The use of Nemozole may cause the following side effects:
- headache and dizziness;
- increased blood pressure and body temperature;
- dry mouth, nausea, vomiting and diarrhea;
- pain in the abdominal area;
- decrease in the level of red blood cells, white blood cells and platelets in the blood;
- problems with liver and/or kidney function;
- itchy skin rashes and temporary hair loss.
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Overdose
Exceeding the dosage of Nemozol indicated in the instructions leads to increased side effects of the drug. Gastric lavage in the usual way is indicated, as well as taking enterosorbents.
Interactions with other drugs
Since Nemozol promotes an increase in the rate of biotransformation of many pharmacological agents, it is not recommended to use it simultaneously with other drugs. Also, Nemozol should not be taken in combination with the anthelmintic agent Biltracid; corticosteroids with dexamethasone; drugs that block H2-histamine receptors (Cimetidine Cinamet, Aciloc, Histodilum, etc.).
Storage conditions
Storage conditions for Nemozol (tablets and suspension): at a temperature of +15-25°C.
Shelf life
Shelf life: three years.
Reviews
Doctors' reviews regarding the effectiveness of Nemozol for giardiasis are positive. For more details, see - Treatment of giardiasis
An analogue of Nemozol for giardiasis is also noted - Mebendazole (other trade names: Mebenzol, Antiox, Nemazol, Vermin, Vermox). Its active substance mebendazole (5-benzoyl-2-methoxycarbonylamino-benzimidazole) has an identical mechanism of pharmacological action.
What is better to use, Nemozol or Macmiror for giardiasis, in each specific case the attending physician should decide. In this case, many factors are taken into account, including the fact that the dosage of Macmiror (Nifuratel) is twice as high as that of Nemozol, and the course of treatment is longer. More useful information in the material - Tablets for giardia
Attention!
To simplify the perception of information, this instruction for use of the drug "Treatment of giardiasis with nemozole: schemes, analogs" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.