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Obradex
Last reviewed: 03.07.2025
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Obradex is a combined anti-inflammatory drug for use in ophthalmology. ATX code - S01C A01. Synonyms: Tobradex, Tobrazone, Dexatobropt.
Indications Obradex
Indications for the use of this drug are infectious eye diseases: non-purulent and allergic conjunctivitis, keratitis, keratoconjunctivitis (without damage to the epithelium), blepharitis, blepharoconjunctivitis, iritis, iridocyclitis, scleritis, episcleritis.
Obradex is prescribed for inflammation that occurs after eye trauma and ophthalmological surgeries.
Release form
Release form: eye drops in 5 ml dropper bottles.
Pharmacodynamics
Obradex contains the active ingredients: tobramycin sulfate and dexamethasone, as well as excipients: benzalkonium chloride (antiseptic), disodium ethylenediaminetetraacetate (food antioxidant E386), sodium dihydrogen phosphate (food stabilizer E339), sodium metabisulfate (preservative E-223), sodium chloride, distilled water.
The aminoglycoside antibiotic Tobramycin is active against gram-negative and some gram-positive bacteria; it acts on the rRNA of the ribosomes of microbial cells and blocks the process of protein synthesis in them, which leads to the death of bacteria. Dexamethasone is a glucocorticoid with anti-inflammatory, anti-allergic and desensitizing properties; it reduces the activity of the intracellular enzyme phospholipase A2, which prevents the release of inflammatory mediators. Due to this, an anti-edematous effect is achieved and the permeability of capillaries in the lesion is normalized.
Dosing and administration
Obradex - instillation into the conjunctival sac. A single dose for an adult is 1-2 drops (in one eye). It is recommended to instill the eyes every 5 hours; in severe cases - every 1-2 hours. The maximum duration of use of Obradex is 7 days.
Before using this medication, hard contact lenses should be removed (and not put back on earlier than 20 minutes after instillation); the use of soft lenses should be discontinued until the end of treatment.
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Use Obradex during pregnancy
Use during pregnancy and lactation is not recommended.
Contraindications
Obradeks is contraindicated for use in case of individual intolerance to active or auxiliary components (especially to benzalkonium chloride); in case of glaucoma, thinned cornea, in case of eye diseases associated with the herpes simplex virus, mycobacteria and fungi. Not used in children under 5 years of age.
Side effects Obradex
Side effects of the drug include: burning and pain in the eyes after instillation; itching, hyperemia and swelling of the eyelids and the entire face; lacrimation; increased intraocular pressure; headache, deterioration of vision.
In some cases, glaucoma or cataracts develop. When the sclera thins, there is a risk of its perforation.
Overdose
Obradex causes increased side effects (irritation, redness and itching of the mucous tissues of the eye, swelling of the eyelids, etc.). In such cases, it is necessary to rinse the eyes with water.
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Storage conditions
Storage conditions: in a place protected from light and out of reach of children, at a temperature of +8-25°C.
Shelf life
The shelf life is 24 months; after opening the bottle, the drug is suitable for use within 28 days.
Attention!
To simplify the perception of information, this instruction for use of the drug "Obradex" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.