Terofun

Terofun is a nasal decongestant drug with a systemic effect. Included in the group of sympathomimetics.

The triprolidine component inhibits itching and systemic hyperemia, which occur during endogenous histamine secretion.

Pseudoephedrine has a powerful anti-edema effect, and at the same time has an indirect and direct sympathomimetic effect. The substance stimulates cardiac function, has a bronchodilating and vasoconstrictor effect, increases blood pressure values, and also stimulates the activity of the central nervous system. [1]

If we compare it with ephedrine, it can be noted that pseudoephedrine is much less likely to cause an increase in blood pressure and the development of tachycardia, and also more weakly stimulates the functional activity of the central nervous system. [2]

Indications Terofun

It is used in the treatment of symptoms of the common cold (this includes a vasomotor rhinitis, which has an allergic genesis), and at the same time with flu and colds .

Release form

The drug is produced in the form of tablets - 10 pieces inside a cell package; in a pack - 2 such packages.

Pharmacodynamics

Triprolidine is a competitive histamine H1 terminal blocker from the alkylamine subclass. Has a minimal anticholinergic effect; used as a symptomatic substance - eliminates the manifestations associated with the secretion of histamine.

Pseudoephedrine helps to stimulate the action of the α-adrenergic receptors of the vessels located inside the mucous membrane of the respiratory tract, leading to their narrowing, which allows you to remove edema in the nasal mucosa, reduce tissue hyperemia and relieve nasal congestion, thereby increasing the throughput of the respiratory tract.

Pharmacokinetics

Pharmacokinetics of a drug is associated with the pharmacokinetic characteristics of each of its elements.

Pseudoephedrine with triprolidine is well absorbed into the intestine after oral administration.

Triprolidine is involved in the synthesis with plasma protein. When taking the 1st tablet, the level of intraplasmic Cmax of triprolidine reaches approximately 5.5-6.0 ng / ml and is noted after 120 minutes. The half-life of triprolidine is approximately 3.2 hours. Metabolic components are formed by hydroxylation and oxidative dealkylation. Excretion of metabolites is carried out in the urine. Only about 1% of the administered triprolidine remains unchanged during excretion.

The Cmax values of pseudoephedrine are approximately 180 ng / ml and are recorded after 2 hours. The half-life of pseudoephedrine is 5.5 hours.

A certain volume of pseudoephedrine is involved in intrahepatic metabolic processes with the formation of an inactive metabolic component. Pseudoephedrine, together with its metabolites, is excreted by the kidneys (approximately 55-75% of the unchanged form), over a period of 24 hours. The rate of secretion of pseudoephedrine increases as a result of acidification of urine and decreases, respectively, with an increase in its pH.

Dosing and administration

It is required to use 1 tablet of the medication 3-4 times a day.

The duration of the therapeutic cycle is selected by the doctor, it often lasts 4-5 days. If you skip an appointment, you do not need to double the portion. The medicine is taken with milk or food.

• Application for children

Cannot be used in pediatrics.

Use Terofun during pregnancy

It is forbidden to appoint Terofun to pregnant women.

Triprolidine with pseudoephedrine are secreted with breast milk in small volumes, but there is no information regarding their effect on the infant, therefore, the drug is not used for HB.

Contraindications

Among the contraindications:

• severe intolerance associated with the elements of the medication;
• an increase in blood pressure (severe);
• proceeding in a severe form of ischemic heart disease;
• coronary atherosclerosis;
• atherosclerosis affecting cerebral vessels;
• CH;
• thyrotoxicosis;
• severe hepatic lesions;
• use in combination with MAOIs or within 14 days after their cancellation (this includes the antibacterial drug furazolidone). The combination of pseudoephedrine with this category of medications can provoke an increase in blood pressure.

Side effects Terofun

The main side effects:

• lesions affecting the work of the NS: insomnia, headaches, tremors, dizziness and agitation. Occasionally, hallucinations, visual disturbances, seizures, muscle weakness and drowsiness occur;
• problems with the work of the CVS: arrhythmia, tachycardia or collapse;
• allergy symptoms: itching, hyperemia in the sternum and epidermal rashes;
• others: vomiting, diarrhea, dysuria, urinary problems, dyspnea, anorexia, xerostomia or dryness of the mucous membranes of the nasopharynx and throat. 

Overdose

Intoxication causes tachycardia, cardiac arrhythmias, an increase or decrease in blood pressure and hallucinations. In addition, there is mydriasis, weakness, dryness of the epidermis along with mucous membranes, tremors, vomiting, lethargy and nausea, as well as respiratory depression, hypertensive crisis and changes in mental state.

Gastric lavage is performed, and at the same time the use of activated carbon. It is necessary to maintain the function of the CVS, and besides this breathing. The rate of elimination of pseudoephedrine is potentiated by dialysis or forced diuresis.

Interactions with other drugs

The combination of the drug with tricyclics, sympathomimetics (among them appetite suppressants with decongestants, and in addition amphetamine-type psychostimulants) or MAOIs (furazolidone), which affect the catabolic activity of sympathomimetic amines, causes an increase in blood pressure.

Because Terofun contains the element pseudoephedrine, it can lead to partial neutralization of the antihypertensive effect of drugs that affect sympathetic activity (among them betanidine, derisoquine with bretilium, methyldopa, guanethidine and α- with β-blockers).

Although there is no objective information, people who use the medication need to stop taking alcoholic beverages or other sedatives that have a central mechanism of influence.

Storage conditions

Therofun must be stored in a place away from sunlight, moisture and the access of small children. Temperature indicators - no more than 25 ° С.

Shelf life

Terofun can be used within a 24-month period from the date of manufacture of the pharmaceutical product.

Analogs

The analogues of the medication are Aktifed, Orinol, Koldar with Therosim, Zestra and Trifed with Mili nose, as well as Coldflu plus.