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Tagista
Last reviewed: 03.07.2025
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Active ingredient - Betahistinum (betahistine)
Manufacturer: Makiz Pharma, Russia
The pharmacological action is aimed at improving microcirculation.
Indications Tagista
It can be prescribed by a doctor in the event of: "ringing" in the ears; labyrinthitis; persistent hearing loss; atherosclerosis of the cerebral vessels; vertebrobasilar insufficiency; traumatic encephalopathy; inflammation of the vestibular nerve; dizziness after neurosurgery.
The tablets are flat-cylindrical in shape. The color is cream or white, with a cross line for easy division.
- 10 pcs. – in a blister (3, 5), which is stored in a cardboard package.
- 30 pcs. - in blisters (1, 2, 3), which are stored in a cardboard package.
- 30 pcs. – in a plastic jar (1), which is placed in a cardboard bag.
[ 1 ]
Release form
Each tablet may contain a different amount of betahistine dihydrochloride: 8; 16 or 24 mg. Tagista is sold with a prescription.
Analogues:
- Stugeron
- Cinnarizine
Pharmacodynamics
Betahistine is a structural analogue of endogenous histamine. It is a strong antagonist of histamine H3 receptors. Initially, it was believed that betahistine's action is responsible for stimulating H1 receptors in the blood vessels of the inner ear and locally dilating and increasing the permeability of these vessels. However, the effect on H1 receptors was insignificant. After binding to the H3 receptor, it eliminates the inhibitory effect of histamine and increases the release of neurotransmitters. The amount of histamine released increases and stimulates H1 receptors, following the dilation of the blood vessels of the inner ear.
In addition, betahistine increases the levels of neurotransmitters such as serotonin in the brain, which in turn inhibits the vestibular nucleus, thereby preventing vertigo (vestibular disorders and dizziness).
Betahistine increases the permeability of the pulmonary epithelium and has a positive inotropic effect.
Pharmacokinetics
The active substance is quickly absorbed along the entire length of the gastrointestinal tract and practically does not bind to plasma proteins. After one hundred and eighty minutes, the highest concentration of the drug in the blood is achieved. Tagista is excreted from the body with urine within 24 hours.
[ 4 ]
Dosing and administration
The drug Tagista is prescribed orally and taken with food.
The tablets are taken as follows: betagistine 8 mg - three times a day, 1-2 tablets; 16 mg - three times a day, three times a day, and 24 mg - 1 tablet twice a day.
In general, improvement is already noticeable at the initial stage of treatment. A stable therapeutic effect is achieved by the end of the second week of therapy. It may increase over several months. The duration of treatment is determined by the doctor individually, but the standard course of therapy takes quite a long time.
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Use Tagista during pregnancy
It is not advisable to use the drug during breastfeeding and pregnancy. It is not known whether it can accumulate in breast milk. The age limit is also under 18 years due to the lack of data on safe and effective use.
Contraindications
- individual intolerance to betahistine dihydrochloride or fillers;
- diseases of the duodenum and stomach;
- rare hereditary problems with galactose intolerance, lactase deficiency, glucose-galactose malabsorption, since the medicine contains lactose);
- breathing problems (asthma attacks);
- malignant neoplasms of the adrenal glands (including pheochromocytoma).
[ 5 ]
Side effects Tagista
Among the negative effects of the drug, the most common from the digestive system are attacks of nausea, vomiting; allergic manifestations - itching of the skin, urticaria, rashes, in addition, there are cases of the development of Quincke's edema, headache, increased heart rate. If drowsiness occurs, it is necessary to refrain from driving any vehicle.
These symptoms usually disappear when the drug is taken with food or the dose is reduced. If any of the listed side effects occur, you should immediately inform your doctor.
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Overdose
In case of an overdose of Tagist, nausea and vomiting are possible, convulsions may occur. Symptomatic therapy should be carried out, including gastric lavage and administration of activated carbon. In case of an overdose, it is necessary to immediately contact a doctor to adjust the treatment regimen.
Storage conditions
- Storage must be carried out in the original packaging to protect from sunlight and moisture;
- The optimum storage temperature should not exceed 30 °C.
- It is not recommended to use the medicine after the expiration date indicated on the package;
- It is not recommended to dispose of it in the sewer or household waste.
- Keep out of reach of children
Shelf life
Store for 36 months (three years). The production date and expiration date are shown on the packaging.
Attention!
To simplify the perception of information, this instruction for use of the drug "Tagista" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.