^

Health

Taghera forte

, medical expert
Last reviewed: 03.07.2025
Fact-checked
х

All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.

We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.

If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.

The drug Tagera forte is one of the most effective drugs for combating anaerobic and protozoan infections. Therefore, this medication copes well with infectious diseases caused by the above pathogens.

In the medical classification, the drug Tagera forte belongs to the pharmacotherapeutic group of drugs with antimicrobial properties, which are intended for systemic use. This highly effective drug belongs to a subgroup of antibacterial drugs that are produced on the basis of imidazole (or are derivatives of 5-nitroimidazole).

The high degree of antimicrobial activity of the drug is noted in the fight against a large number of obligate anaerobic bacteria and protozoa. Therefore, the drug has a wide spectrum of action. Its advantages include the ability to neutralize the vital activity of some representatives of facultative anaerobic microflora (microaerophiles), which has a positive effect on the healing of those diseases that are caused by these microorganisms.

Indications Taghera forte

Indications for use of the drug Tagera forte are as follows:

  • Therapy of intestinal and extraintestinal amoebic dysentery.
  • Treatment of trichomoniasis and giardiasis.
  • Treatment of bacterial vaginosis, as well as vaginosis caused by trichomonas.
  • Treatment of urethritis caused by trichomonas.

Release form

The release form of the drug Tagera forte is as follows:

  • The drug is produced in white oval tablets, similar to capsules, coated with a film, with a dividing line on one side.
  • Each tablet contains one gram of the active ingredient – secnidazole.
  • The auxiliary components of each tablet include microcrystalline cellulose, corn starch, gelatin, sodium starch glycolate, colloidal silicon dioxide, and magnesium stearate.
  • The shell of each tablet is coated with hydroxypropyl methylcellulose, macrogol 6000, titanium dioxide (E171).
  • The medicine is available in a cardboard package containing a blister plate containing two tablets of the medicine. Additionally, the package contains instructions for use of the medicine.

Pharmacodynamics

The pharmacodynamics of the drug Tagera forte are as follows:

  • The active ingredient of the drug, secnidazole, is a semi-synthetic derivative of nitroimidazole.
  • Secnidazole has antibacterial and antiprozoal effects.
  • The mechanism of action of the drug is as follows: the active component of the drug is able to penetrate into the cell of the microorganism causing the infectious disease. Then secnidazole is integrated into the metabolic processes inside the foreign cell by restoring the 5-nitro group under the influence of reductases. After which the restored secnidazole begins to interact with the DNA of microbes and bacteria, thereby producing violations of its spiral structure, breaking chains and suppressing the production of nucleic acids in it. Thus, secnidazole leads to the death of bacterial cells and protozoan cells.
  • The medicine Tagera forte is effective against the following microorganisms – Trichomonas vaginalis, Entamoeba histolytica, Giardia lamblia.

trusted-source[ 1 ], [ 2 ]

Pharmacokinetics

The pharmacokinetics of the drug Tagera forte are as follows:

  • The active substance of the drug, secnidazole, is capable of being absorbed by eighty percent after oral administration.
  • The maximum amount of the active ingredient in the blood serum is observed three to four hours after taking the drug.
  • The concentration of the drug in blood plasma is linear when taking therapeutic doses from half to two grams.
  • The half-life of the active substance from blood plasma is about twenty to twenty-five hours.
  • Secnidazole has the ability to penetrate the placental barrier during pregnancy and is observed in breast milk during breastfeeding.
  • Most of the absorbed drug is slowly excreted from the body through urine. This occurs as follows: sixteen percent of the dose of the drug taken is excreted within seventy-two hours.

Dosing and administration

The following method of administration of the drug and the corresponding doses are recommended:

  • The medicine is taken orally half an hour before meals. The tablet is washed down with a sufficient amount of water.
  • Doses for adult patients:
    • for intestinal amoebic dysentery - two grams in a single dose;
    • for amoebic processes in the liver - one and a half grams once a day for five days;
    • for trichomoniasis and bacterial vaginosis for the patient and his partner - two grams in a single dose;
    • for giardiasis - two grams, as a single daily dose for three days.
  • Doses for pediatric patients (from twelve years of age):
    • for amoebic dysentery and giardiasis - at a rate of thirty mg of the drug per kg of body weight, that is, from one to one and a half grams in a single dose;
  • The above dose can be divided into two doses over three days (for similar diseases as those indicated above).
  • It is prohibited to consume alcohol of any strength during the treatment process, as well as for at least one day after the end of therapy.

trusted-source[ 3 ], [ 4 ], [ 5 ], [ 6 ]

Use Taghera forte during pregnancy

The use of Tagera Forte during pregnancy and lactation is prohibited.

If it is necessary to use the drug, breastfeeding should be interrupted or stopped completely.

Contraindications

Hypersensitivity to one or more components of the drug. This applies to a greater extent to imidazole derivatives.

History of pathological conditions of the blood formula.

The presence of organic diseases of the central nervous system.

The drug is contraindicated for use during pregnancy and breastfeeding in women.

The drug is not prescribed for children under twelve years of age, since the safety and effectiveness of secnidazole for children in this age group is unknown.

The drug is prohibited for use by persons who are forced to drive a car or operate any other complex machinery.

Side effects Taghera forte

The following side effects were identified during treatment with Tagera Forte:

  • The active component of the drug - secnidazole - is well tolerated by patients. Therefore, a large number of side effects occur in a mild form and for a short period of time.
  • When taking Tagera Forte, symptoms of gastrointestinal tract dysfunction may appear, namely signs of dyspeptic symptoms, nausea, vomiting, gastralgia, metallic taste in the mouth, glossitis (inflammation of the tongue), stomatitis.
  • Allergic reactions may occur (reddening of the skin, rashes, itching, etc.).
  • Manifestations of dizziness, headaches and other neurological disorders are observed in rare cases.
  • Rare side effects include tremors and seizures.
  • When taken by a small number of patients, symptoms of nervous system disorder may be observed: signs of ataxia, peripheral neuropathy, impaired coordination of movements, paresthesia.
  • Among the side effects of the drug, in rare cases, the appearance of signs of reversible moderate leukopenia is noted, as signs of a disorder in the functioning of the hematopoietic system.
  • Signs of side effects of the drug Tagera forte are usually expressed in a moderate form and do not affect the patient's treatment process.
  • If clearly expressed side effects of the drug occur, it is necessary to stop taking Tagera Forte.

Overdose

There is no information on cases of accidental or intentional overdose of the drug due to the fact that such cases have not been observed.

Overdose of Tagera forte stimulates the increase of signs of side effects of the drug.

Overdose of the drug causes symptoms of leukopenia and ataxia.

Method of treating a patient in case of drug overdose:

  • discontinuation of the drug;
  • gastric lavage;
  • prescribing supportive and symptomatic therapy.

trusted-source[ 7 ]

Interactions with other drugs

As a result of the practical use of the drug Tagera forte, the following interactions of the drug with other medications were identified:

  • The active substance of the drug, secnidazole, is capable of stimulating the anticoagulant (preventing blood clotting) effect of coumarin derivatives. This increases the risk of bleeding in certain health problems of the patient.
  • It is prohibited to combine the use of secnidazole with disulfiramine due to the fact that in this case, the combination of these substances leads to the occurrence of delirium attacks, as well as dizziness.

trusted-source[ 8 ], [ 9 ], [ 10 ]

Storage conditions

The storage conditions for the drug Tagera forte are as follows:

  • The medicine must be kept in a dry place protected from light.
  • The drug should be kept at a temperature of no more than twenty-five degrees Celsius.
  • The medicine should be carefully hidden from the reach of children.

trusted-source[ 11 ], [ 12 ]

Shelf life

The shelf life of the drug Tagera forte is thirty-six months.

It is prohibited to use the medicinal product for treatment after the expiration date indicated on the package.

trusted-source[ 13 ]

Attention!

To simplify the perception of information, this instruction for use of the drug "Taghera forte" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

You are reporting a typo in the following text:
Simply click the "Send typo report" button to complete the report. You can also include a comment.