Tablets from obesity

In the modern world, overweight is a common problem. Often, in order to bring the body back to normal, people resort to various alternatives and medicines that help to reduce and further control the weight. Indeed, there are so-called tablets from obesity - drugs that can be based on several principles of action: blunting appetite, speeding up metabolic processes or blocking the assimilation of food.

Indications for the use of tablets from obesity

The use of tablets against obesity is shown in the following patients:

• people who have a body mass index equal to or greater than 30, in the absence of contraindications to the use of such drugs;
• people who have a mass index equal to or greater than 27, and there are also diseases, provoked by excess weight.

The mass index demonstrates the fit of the patient's height and weight - it is used to accurately determine the lack, rate or excess of body weight. It is considered that for female representatives such an index should be in the values of 20-22, and for the male - 23-25.

To find out your index, it is enough to make several calculations:

• body weight in kilograms should be divided twice into height in meters;
• The received indicator corresponds to your index.

For example, your weight is 60 kg, and height - 1 m 65 cm. Divide 60 by 1.65 - we get 36.36. This number is divided again into growth: 36.36 divided by 1.65 - we get 22.03. This is your index.

Form of issue

Tablets from obesity are most often presented as enteric-insoluble capsules. Such capsules have a modified release, that is, the drug should be stable and not disintegrate in the acid of the gastric juice, but be released only in the intestine. Capsules most often have an acid-resistant shell.

Capsules with medicine inside have many advantages over other dosage forms:

• they are attractive in appearance;
• they are easy to swallow;
• thanks to the capsule, the medicine gets to that part of the digestive tract, which is necessary.

Obesity drugs, presented as hard tablets or granules, are less common.

[1], [2], [3], [4]

Pharmacodynamics tablets from obesity

Most drugs from obesity reduce the absorption of lipids in the intestinal cavity. For example, drugs such as Orsoten, Orlistat and Xenical inhibit enzymes that break down fats. Due to this, fats can not digest and in an unchanged form leave the body with feces. Gradually, this causes a decrease in the intake of caloric food ingredients in the circulatory system and, correspondingly, a decrease in body weight.

Pharmacodynamic properties Reduxin, Goldlayne and Sibutramine are based on the central effect of the drugs. The increase in the number of neurotransmitters in synaptic ligaments stimulates the central receptors of serotonin and adrenergic receptors. As a result, the person's sense of satiety becomes predominant, the need for a regular intake of food is reduced, the energy production in the body is increased.

There is also an indirect effect of sibutramine on the brown appearance of adipose tissue, responsible for thermoregulation.

Often among the additional substances in the tablets is cellulose. It is a sorbent substance that binds and removes toxic substances, microbes, end products of metabolism, allergens, etc. From the body, which additionally relieves and cleanses the body.

Pharmacokinetics of tablets against obesity

Preparations based on sibutramine are well absorbed in the digestive system (about 80%). Biotransformation occurs in the liver - two active metabolic substances are formed. If you take a single dose of the drug, the maximum content of the active component in the blood can be observed after 80 minutes, and the peak content of active metabolites - for 3-4 hours. Drinking the drug on a full stomach lowers the active concentration of metabolic substances by 30% and lengthens the peak concentration phase by 3 hours. The speed of the drug in the tissues does not affect food intake.

Sibutramine and its metabolites are excreted by the urinary system for 16 hours.

Preparations based on orlistat (Orsoten, Xenical) have a therapeutic effect for 1-2 days from the beginning of admission. The same effect continues for 1-3 days after the end of the course of treatment. Orlistat is practically not absorbed into the systemic bloodstream, acting directly in the intestinal cavity and leaving the body with a fecal mass (at least 97%). The blood test, conducted 8 hours after taking the drug, did not show its presence in the circulatory system.

Names of tablets from obesity

Complex and neglected types of obesity are treated only under the supervision of specialists, as in the therapy scheme, as a rule, use potent medicines. By such means should be understood drugs that dull the feeling of hunger and prevent the absorption of fat.

• Tablets from obesity Xenical - interfere with the absorption of fats in the lower parts of the digestive tract, resulting in them leaving the body with feces in undigested form. Xenical acts directly on the digestive organs, inhibiting the production of enzymes - lipases, which participate in the cleavage of fats and are conducive to their assimilation. Very common drug. It is taken with food together, 1 capsule per day (120 mg).

Usually, on the second day after the start of treatment, you can find particles of undigested fat in the feces. During this period, it is desirable to eat low-fat and low-carbohydrate foods, since otherwise the development of intestinal frustration is possible.

• Orsoten is an analog of Xenical, of which we spoke above. The same active substance, the same principle of action, the same dosage. •
• Goldline (Sibutramine) - a remedy that directly affects the central nervous system. By exerting an influence on brain activity associated with reflecting a feeling of satiety in the body, Goldline makes the brain think that it is full and the patient does not feel hungry at the end. In addition, this drug allows you to generate energy from your own reserves in the body, which only contributes to weight reduction. Goldline is very effective with regular overeating, as well as in patients with type II diabetes mellitus.

The course of treatment can begin with the daily intake of 10 mg of the drug, sometimes the dosage is increased to 15 mg per day. Duration of treatment - no more than three months, after which you should take a break. •

• Reduxin is a complete analog of Goldline (active ingredient is Sibutramine).
• Lindaksa - an analog preparation Goldline, Reduxin (the active ingredient is Sibutramine).

Dosing and Administration

Means for obesity based on orlistat (Orsotene, Xenical) are taken orally when eating. It is advisable to follow a diet with a balanced caloric content during the treatment course, with the amount of fat not exceeding 30% per day. It is not recommended to overeat. Duration of the course and dosage is prescribed by the doctor. Normally take 1 capsule of the drug from 1 to 3 times a day, but not more than 3 capsules per day.

Means based on sibutramine (Reduxin, Lindax, Goldline) are taken in an amount of 5-10 mg once daily. A tablet (capsule) should be taken in the morning without chewing, drinking a glass of water, regardless of eating. The duration of treatment is determined by the doctor, but it is not recommended to take the drug for more than 90 days.

Treatment of pills from obesity is necessarily conducted by a medical specialist who has sufficient practical experience in the therapy of excess weight. The effect of treatment will be more rapid and persistent if the drug intake is combined with proper nutrition and dosed physical exertion.

[11], [12], [13], [14]

Use of tablets against obesity during pregnancy

Tablets and other drugs for obesity are not recommended for use during pregnancy and breastfeeding. The fact is that the action of the drugs has not been sufficiently studied to rest assured that these drugs do not have a negative effect on the course of the gestation process, on the growing fetus, and on lactation on the development of the child, as well as the usefulness and quantity of breast milk . Moreover, during the course of treatment with obesity drugs for women of childbearing age, it is recommended to use contraceptive medications or external contraception to exclude the possibility of pregnancy during therapy.

Contraindications to the use of tablets against obesity

Before you write out this or that medicine for obesity, the doctor will note the absence of contraindications to their use. In addition to pregnancy and lactation period, such contraindications include:

• diabetes;
• hypertonic disease;
• cardiological diseases;
• kidney pathology;
• increased intraocular pressure;
• alcoholism and drug addiction;
• hyperthyroidism, hypothyroidism, endemic goiter;
• mental disorders, severe depressive conditions;
• headache of unknown origin;
• preparation for surgical intervention with anesthesia;
• allergic addiction;
• childhood;
• syndrome of chronic malabsorption, cholestasis;
• serious eating disorders (nervous type of anorexia or bulimia).

[5], [6], [7], [8], [9], [10],

Side effects of tablets from obesity

Medicines for obesity can only be used for a short period of time. First, such drugs lose their effectiveness when taken for more than a few weeks. Secondly, in the course of time unwanted side effects may appear:

• tachycardia (frequent heartbeat);
• increased blood pressure;
• increased sweating;
• Disorders of bowel function in the form of constipation;
• sleep disorders;
• pain in the head;
• disorders of the nervous system - unreasonable feelings, anxiety, etc .;
• dryness in the oral cavity;
• violations of the menstrual cycle in women;
• infection in the respiratory or urinary tract;
• convulsions;
• allergic skin rashes.

Often observed digestive disorders in the form of epigastric pain, bloating, diarrhea. Such symptoms become worse if you consume foods with a high percentage of fat during treatment.

Overdose

When using an unreasonably high dose of pills against obesity, the patient may have a risk of developing side effects that are specific to a particular drug. In such cases, no special therapy is required, since there is no specific antidote agent for this situation. It is recommended to monitor the patient's condition throughout the day after taking an extra dose. Symptomatic therapy may be used.

The expediency of hemodialysis and forced diuresis procedures was not established, but is in doubt.

Interactions with other drugs

Orlistat with a co-administration can lead to a decrease in the content of cyclosporine in the blood. If the drugs are taken together, it becomes necessary to control the content of cyclosporine and correct its dosage.

When sharing orlistat derivatives in anticoagulant drugs is recommended to monitor the prothrombin time.

Orlistat and other tablets on its basis reduce the bioavailability of fat-soluble vitamin substances - these are vitamins E, A, K, ergocalciferol and carotene. Between the use of these drugs should pass at least 2 h.

Orlistat and thyroid medications are taken under strict medical supervision. The same applies to iodine preparations.

Preparations of sibutramine should not be taken together with drugs for the treatment of depressive disorders, with medications for migraine (for example, sumatriptan, ergotamine), with strong analgesics (fentanyl, etc.), with medications blocking the cough reflex.

It is highly not recommended to drink alcohol during the therapy with pills against obesity, since the consequences of this can be unpredictable.

Storage conditions

Obesity drugs can be stored in the temperature range from + 15 to + 25 ° C, away from children's access.

The expiration date of such funds should be specified according to the information on the package: usually this period is from 2 to 3 years.

Reviews about tablets from obesity

Many users who have tried on themselves the action of tablets from obesity, often come to the conclusion that without changing the principles of nutrition and lifestyle, the effect of drugs may not be so noticeable. Moreover, severe degrees of obesity should be treated only under the supervision of doctors, because independent treatment can affect the state of the cardiovascular and endocrine system, the digestive system and the musculoskeletal system - all systems that for many years are "used" to extra pounds and due to sudden weight loss can fail.

In addition, there is another problem in the treatment of obesity tablets.

At present, many non-certified non-prescription drugs have appeared that massively offer Internet users, advertising, mailings and customized reviews. The Ministry of Health strongly advises caution when using such unexplored means, as their safety and effectiveness are absolutely not guaranteed by anyone. Well, if such pills prove to be just useless "dummies". But we must not forget that they can also bring harm.

In most cases, before buying supplements and pills from obesity, it is better to visit a doctor at least once and clarify information about a particular drug: how good it is, whether it is suitable for you, what dosage should be, etc., topical issues. Do not be shy of these questions: it's quite normal and logical, if you think and care about your health.