Tablets from low back pain

Although with the help of pain medication can not get rid of the cause of back pain, including in the lower back, but to eliminate the unpleasant symptoms in complex treatment, they will be very helpful. Tablets for back pain are divided into several separate medicinal groups, and the choice of a suitable medication in this case will depend on the symptomatology, the cause that caused the pain, etc.

Indications of the tablets for low back pain

Among the indications for the use of tablets are acute pains, arthrosis, ischialgia, hernia of intervertebral discs, as well as arthritis and osteochondrosis. They are also used to eliminate pain in osteoarthritis.

[1], [2]

Release form

Tablets with analgesic effect from the NSAID group are Nimesil, Movalis, as well as Diclofenac, Naproxen and Ibuprofen.

Back pain is also aided by medications (LS) from the muscle relaxant category - such as Baclofen and Midokalm, as well as Cyclobenzoprite.

With back and back pain, corticosteroids are effective , among which tablets such as Diprospan, Prepol and Dexamethasone, and in addition Prednisolone and Methylnisolone, as well as Supromethyl and Flosteron.

Synthetic narcotic drugs may also be used . In this case, drugs with a weak effect include Tramadol with Codeine, and to potent tablets - Hydrocodone, Morphine, and Hydromorphone and Fentatin.

Tablets from back pain in the lower back

With pains in the back, almost everyone came across. They can arise for various reasons: such as lifting heavy objects, sciatica, pinched nerves, osteochondrosis, scoliosis, as well as severe muscle strain. In severe pain, anesthetizing pills should be used, but remember that they eliminate only the symptom (pain), and not the cause of the disease. Nowadays, many drugs are produced that contribute to the elimination of pain. They can be divided into several separate groups: hormonal drugs, NSAIDs, narcotic drugs and muscle relaxants.

[3], [4], [5], [6],

Tablets from low back pain with a hernia

Pain in the lumbar region with intervertebral hernia is eliminated with NSAIDs. Most often, for this use ibuprofen, coxibs, diclofenac, as well as meloxicam. It should be remembered that, because of the risk of side effects, these drugs should not be consumed more than 15-20 days, and also use them as a permanent medicine. It is necessary to take them only when the pain is exacerbated. Other drugs are ineffective with pain in the back and with a hernia.

The properties of tablets from low back pain are examined using the example of Nimesil.

Pharmacodynamics

Nimesulide is an NSAID from the sulfonamide category. It has antipyretic, anti-inflammatory and analgesic properties. The active substance of the preparation slows down the action of the cyclooxygenase enzyme, which carries out the process of synthesis of prostaglandins (PG), suppressing mainly COX-2.

[7], [8], [9], [10],

Pharmacokinetics

After oral administration, the drug is absorbed from the digestive tract, and the maximum saturation in the blood plasma reaches 2-3 hours. The plasma proteins bind to 97.5%. The half-life lasts 3.2 to 6 hours. The active substance easily passes through hematoparenchymal barriers.

Metabolism occurs in the liver with the participation of isoenzyme of cytochrome type P450CYP 2C9. Among the decay products, the active pharmacological substance hydroxynimidesulide (parahydroxy-derivatized nimesulide) is the main one. Excretion of this component from the body occurs with bile under the guise of a metabolite (it can be detected only in the form of glucuronic acid - approximately 29%). Nimesulide is excreted through the kidneys (approximately 50% of the dose used).

[11], [12], [13]

Dosing and administration

Movalis should be taken orally at a dosage of 7.5-15 mg 1 rub. / Day.

Naproxen adults are prescribed in a daily dose of 500-1000 mg for 1-2 doses. Daily dosage may be increased to 1500 mg, but this use is possible only on a limited time (no more than 2 weeks). If there is a pain syndrome in acute form (for example, with bursitis), the first dose is 500 mg and then 250 mg every 6-8 hours. For children, the dosage is 10-20 mg / kg / day for 2 uses.

Baclofen is consumed orally with food. The initial dosage is 5 mg three times a day. Further, the dose is increased by 5 mg every 3 days until a therapeutic effect is achieved. Often in this case, the dosage will be no more than 20-25 mg three times a day.

The maximum daily dose is 100 mg (only for a short period and only in a stationary mode). If the patient is hypersensitive, the initial dose per day should be 5-10 mg, with a further slow increase. If renal failure is observed in a chronic form or hemodialysis is performed, the daily dose should be 5 mg. Children under 10 years of age per day should be prescribed 0.75-2 mg / kg; children after 10 years of -2.5 mg / kg. The initial dosage is 1.5-2 mg / kg four times a day, and the maintenance dose (children 1-2 years) is 10-20 mg / day and 30-60 mg / day (children 2-10 years). The termination of the use of the medicine occurs gradually (for 1-2 weeks).

[23], [24], [25], [26],

Use of the tablets for low back pain during pregnancy

Since NSAID tablets slow down the synthesis of PG, they can have a negative effect on the course of pregnancy and / or fetal development. As a result, before the due time, Botallov can close the duct, increase the blood pressure in the lungs, and also disrupt the work of the kidneys, which may result in kidney failure, complicated by oligohydramnion. In addition, uterine contractility may decrease, the risk of bleeding may increase, and peripheral puffiness may occur. Therefore, NSAIDs are prohibited for pregnant women.

Miorelaxants during this period are allowed to be administered only under the supervision of a doctor and only in the case of a serious state of health of the future mother.

Contraindications

NSAIDs are not allowed in cases of gastrointestinal ulceration or erosion (especially in acute form), as well as with increased sensitivity to drugs, marked disorders of kidney and liver, and in addition to cytopenia.

Miorelaxants are contraindicated if the patient has such illnesses or conditions:

• Allergic reactions to the drug and its components;
• Hepatic insufficiency, peptic ulcer, myasthenia gravis;
• Children younger than 1 year.

[14], [15], [16], [17],

Side effects of the tablets for low back pain

Among the most common side effects of most NSAIDs are the appearance of problems with the gastrointestinal tract, in which ulcers can form. It is also quite often an adverse reaction is hematological disorders - panmyelophthisis, thrombocytopenia, and neutropenia.

Side effects of muscle relaxants can be such conditions: headaches and dizziness, problems with sleep, weakness in the muscles, the appearance of hallucinations, discomfort and pain in the abdomen, dryness in the oral cavity, lowering of blood pressure, nausea, slowing of pulse rhythm and heart beat, anaphylaxis, and also itching and rashes.

[18], [19], [20], [21], [22]

Interactions with other drugs

Naproxen increases the toxicity index of hydantoin, as well as sulfonamides, anticoagulants of indirect action and methotrexate (inhibits the tubular secretion process). Reduces hypotension, which is caused by β-adrenoblockers, and also reduces natriuretic and diuretic effects of furosemide. In addition, it reduces the rate of elimination of lithium salts, as a result of which the saturation in the plasma of this substance increases. Antatsidy, which contains magnesium with aluminum, as well as sucralfate can reduce the absorption of naproxen.

Movalis greatly reduces the effectiveness of antihypertensive drugs. Also can cause a delay of potassium and sodium, reduces the impact of saluretics. In addition, it can trigger the progression of heart failure, as well as an increase in blood pressure.

[27], [28], [29]

Storage conditions

Tablets from back pain should be kept in a cool place closed from the sun. The maximum temperature of storage of medicines should be within 25-30 degrees.

[30], [31]

Shelf life

Tablets for back pain are allowed to be used for 3-5 years from the date of manufacture.

[32], [33]