Symbicort turbuhaler

Symbicort Turbuhaler exhibits therapeutic activity due to the properties of its 2 active elements - formoterol with budesonide, which have different mechanisms of influence and develop an additive effect on reducing the number of exacerbations of asthma.

The specific effect of formoterol and budesonide allows the drug to be used for supportive procedures and weakening the signs of asthma. [1]

Budesonide is a substance from the GCS category. [2]

Formoterol belongs to the group of β2-adrenergic terminal antagonists. [3]

The active ingredients help to reduce the number of asthma attacks, and at the same time improve bronchial activity.

Indications Symbicort turbuhaler

It is used to perform inhalations in people with asthma or respiratory pathologies, against which chronic obstruction is observed .

Release form

The drug is released in the form of an inhalation powder - inside inhaler bottles, 60 servings each; in a pack - 1 such inhaler.

Pharmacodynamics

Budesonide has an anti-inflammatory effect on the bronchi, which makes it possible to weaken the symptoms of asthma, as well as the frequency of the development of attacks. The substance reduces the edema of the bronchial mucous membranes, reducing the rate of production of sputum with mucus.

Formoterol helps to relax bronchial smooth muscles, which leads to a positive result during COPD therapy. Formoterol has a persistent and rapid therapeutic effect.

Dosing and administration

The drug should not be used at the beginning of therapy for asthma. The titration of the portion is carried out gradually, with a decrease to a minimum, relieving asthma symptoms. At the end of long-term therapy with this medication, when the attacks are stably stopped, it is necessary to switch to drugs containing corticosteroids as an active element.

As a supportive element in asthma, drugs are used in the form of a fast-acting substance in case of an attack. In this case, 1-2 inhalations of 80 / 4.5 μg or 160 / 4.5 μg portions are performed, 2 times a day. For children, 1-2 inhalations of 80 / 4.5 mcg of drugs are used per day. In some cases, it is required to perform up to 4 inhalations 2 times a day.

When a lasting effect is obtained, the dosage is reduced to the minimum limits. During the decrease in the titer of the drug, you can personally reduce the number of inhalations the day before the 1st procedure.

In the case of COPD, the medication is used in portions of 160 / 4.5 mcg, 2 times a day.

Before starting the procedure, it is necessary to remove the cap from the inhaler, after which, holding it vertically, turn the dispenser on it until it stops in one direction. Next, measure the dosage by turning the dispenser in the other direction (1 division in this case is 10 μg of the drug). Then you need to exhale, pinch the tip of the inhaler with your lips, take a deep breath and hold your breath for a while. Before carrying out a new inhalation, remove the bottle from the mouth. If another inhalation is required, the procedure is repeated.

It is necessary to cancel the medication, gradually reducing the dosage.

• Application in children

It is forbidden to use the medicine in persons under the age of 6. Persons 6-11 years of age are required to prescribe a form of drugs with a reduced dosage (80 / 4.5 mcg).

Use Symbicort turbuhaler during pregnancy

Symbicort Turbuhaler is prohibited from prescribing to pregnant women, except in situations where the possible benefit to the woman is more likely than the risk of negative effects on the fetus.

During therapy with the use of drugs, you should not breastfeed.

Contraindications

The main contraindications:

• the presence of allergies to the components of the medication;
• active phase of pulmonary tuberculosis;
• respiratory tract lesions of a viral, fungal or bacterial nature.

Caution is necessary when prescribing to people with pheochromocytoma, hyperthyroidism, aneurysm and high blood pressure, and in addition to diabetics.

Side effects Symbicort turbuhaler

Often, when using drugs, patients develop headaches, tremors, oral candidiasis, palpitations, cough, and moderate irritation in the throat.

Sometimes its use leads to nausea, loss of consciousness, arrhythmias, muscle spasm, and in addition to tachycardia, sleep disorders, extrasystole, anxiety and increased excitability.

Occasionally, the administration of the medication causes bronchial spasm, angina pectoris, taste disturbance, a decrease or increase in blood values of potassium and a decrease in bone density, and in addition, growth retardation, symptoms of drug intolerance (itching, urticaria or dermatitis) and suppression of adrenal activity.

Glaucoma, cataract, or hypercortisolism develops in single use of the drug.

In pediatrics, with the introduction of drugs, depression and depression can be noted.

The use of Symbicort Turbuhaler can provoke an increase in the blood values of glycerol, free-type fatty acids, insulin and keratin derivatives.

Overdose

With intoxication, headaches and tremors may occur. Occasionally, overdose causes arrhythmias, tachycardia, indigestion, and a decrease in blood potassium levels.

With prolonged use of large portions of drugs, adrenal function is suppressed, which may lead to the appearance of hypercortisolism.

Interactions with other drugs

The use together with ketoconazole significantly increases the medicinal activity of budesonide.

The therapeutic effect of formoterol can be weakened in the case of the use of medications that contain β-blockers.

The effect of drugs is prolonged when combined with procainamide, quinidine, antihistamines, antidepressants, disopyramide and phenothiazines.

The combination of the drug with oxytocin, levothyroxine, alcoholic beverages and levodopa increases the risk of negative symptoms associated with cardiovascular function.

The use of Symbicort Turbuhaler and halogenated hydrocarbon substances increases the likelihood of arrhythmia.

The use of MAOIs together with the drug leads to an increased risk of increased blood pressure values.

The likelihood of hypokalemia is potentiated when the drug is used together with GCS, xanthine-based substances, and also with diuretics.

Storage conditions

Symbicort Turbuhaler must be stored in a dry place, closed from the penetration of small children. Temperature values - maximum 30oC.

Shelf life

Symbicort Turbuhaler can be used for a 2-year period from the date of sale of the pharmaceutical product.

Analogs

Medicines Foster and Foradil Combi are analogues of drugs.