Simgal

Simgal has a hypolipidemic effect, slowing down the activity of HMG-CoA reductase.

The drug helps to reduce the number of unhealthy fats in the blood (LDL with triglycerides and VLDL) and total cholesterol, and at the same time increases the levels of healthy fats (HDL). [1]

The medicine is used in case of disorders in which there is an increased level of fat in the blood (when exercise and dietary regime do not demonstrate the desired effect). [2]

Indications Simgal

It is used for hypercholesterolemia  (primary type or hereditary form of homozygous nature), as well as mixed dyslipidemia . In addition, it is prescribed to prevent the development of CVD diseases in people with atherosclerosis or diabetics.

Release form

The release of a therapeutic agent is made in tablets with a volume of 10, 20 or 40 mg. Inside the cell package there are 14 such tablets; inside the box - 2 or 6 such packages.

In addition, tablets (28 pieces each) can be produced inside vials.

Pharmacodynamics

When administered orally, simvastatin participates in hydrolysis with the formation of a derivative, which significantly slows down the action of HMG-CoA reductase. At the same time, there is a decrease in the indicators of cholesterol with low density - by weakening its binding and increasing catabolism.

In addition, there is a decrease in triglycerides with apolipoprotein and an insignificant increase in high-density cholesterol. This leads to a change in the proportions of LDL and HDL levels. [3]

Pharmacokinetics

The medication is well absorbed, regardless of whether it is taken with or without food. It reaches Cmax values after 1-2 hours.

The transformation into a form with therapeutic activity takes place inside the liver. Into the systemic circulation from the liver, about 5% of the administered portion of the drug penetrates. The drug does not accumulate. At least 95% of simvastatin with its active metabolic elements undergoes protein synthesis.

Excretion is realized over a period of 96 hours - together with feces (60%) and urine (13%).

Dosing and administration

The medication is consumed in a portion of at least 10-20 mg / maximum 80 mg per day. Usually the application takes place once, in the evening. It is not recommended to take it with food. If it is necessary to divide the tablet in half, it is not broken by hand, but cut with a knife.

The selection of the dosage is performed by the attending doctor, taking into account the established diagnosis, age and state of health, as well as the nature of the treatment (monotherapy or combination with other medicines).

• Application for children

During the use of drugs in adolescents, there was no effect on the processes of sexual development and growth. Studies in young people have not been conducted.

Use Simgal during pregnancy

There is no information as to whether Simgal can affect the processes of fetal development and is excreted in breast milk.

When planning conception, during gestation, as well as with hepatitis B, it is prohibited to use the medicine.

Contraindications

The main contraindications:

• severe intolerance associated with the components of the drug;
• active liver disease;
• a steady increase in serum transaminase values;
• the use of powerful inhibitors of the activity of the hemoprotein CYPZA4 (for example, nelfinar, telithromycin with erythromycin, itraconazole and clarithromycin with nefazodone).

Side effects Simgal

Sometimes the use of drugs causes such side effects: memory or sleep disorders (nightmares and insomnia), sexual dysfunction and depression.

Occasionally, dizziness, paresthesia, seizures and headaches appear, as well as polyneuropathy or anemia. In addition, sometimes stomach pains, vomiting, stool and digestive disorders, jaundice, hepatitis or pancreatitis are possible. Also, myositis, myopathy, asthenia, muscle spasms appear occasionally. Occasionally there is itching, rashes, alopecia and a syndrome of severe intolerance (vasculitis, photophobia, arthritis, weakness, rheumatic polymyalgia, Quincke's edema, eosinophilia, thrombocytopenia and dyspnoea), as well as an increase in ALP and transaminases.

A single intake of Simgal causes pulmonary interstitial processes or kidney failure.

Overdose

At the moment, there is no information about the deadly poisoning by Simgal. The recovery after intoxication in all passed without the development of complications.

The medicine has no antidote. In case of an overdose, symptomatic actions are taken.

Interactions with other drugs

The introduction of a medication with bosentan leads to a decrease in the level of simvastatin with its derivatives. A dosage change is required, taking into account the indicators of cholesterol.

The combination with danazol, amiodarone, cyclosporine, niacin and hemifibrozil requires a reduction in the dose of drugs to prevent the onset of myopathy.

The combination with telithromycin, itraconazole, clarithromycin, as well as erythromycin, posaconazole, fluconazole and other potent inhibitors of the CYP3A4 component is prohibited. If there is an urgent need for treatment using the above drugs, the use of Simgal is temporarily canceled.

Storage conditions

Simgal should be kept out of direct sunlight. Temperature - within 10-25 ° C.

Shelf life

Simgal is allowed to be used within a 4-year term from the date of manufacture of the therapeutic product.

Analogs

Analogues of drugs are medicines Vabadin, Vasta, Aldesta and Zosta with Vasostat-Health, and in addition Atrolin, Simvakard, Simvostat and Simvagexal with Simva Tad. In addition, the list includes Cardak, Simvalimit, Vastatin with Simvakol, Vazilip and Zokor.

Reviews

Simgal receives good reviews from patients - its high efficiency and good tolerance are noted when used correctly.