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Cygnicef
Last reviewed: 04.07.2025

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Signicef is an antimicrobial and antibacterial drug that is available in the form of eye drops and infusion fluid.
The active element of the drug slows down the action of DNA gyrase, as well as topoisomerase IV, and at the same time suppresses DNA binding and prevents supercoiling, as well as cross-linking of breaks in the DNA chain. In addition, the drug is a catalyst for morphological changes inside bacterial and cell walls, as well as the cytoplasm. [ 1 ]
Indications Cygnicef
It is used for the following disorders:
- infections affecting the adnexa together with the anterior part of the eye (caused by the influence of bacteria demonstrating sensitivity to levofloxacin);
- the need to prevent complications that may arise after ophthalmological surgeries;
- local treatment of eye infections associated with the action of microbes sensitive to levofloxacin.
Release form
The medicinal substance is released in the form of eye drops and a special infusion fluid.
Pharmacodynamics
The drug has an effect on aerobes of gram-negative and -positive nature. In addition, it demonstrates a pronounced effect on Chlamydia trachomatis.
The active element of the drug in the form of eye drops accumulates inside the tear film. Its indicators inside the tear fluid become high quite quickly, remaining at this level for 6 hours. [ 2 ]
Pharmacokinetics
After oral administration, the substance is almost completely and rapidly absorbed from the gastrointestinal tract. Without complications, it penetrates into organs and tissues: bronchial mucosa, lungs, urogenital tract organs, polymorphonuclear leukocytes and alveolar macrophages. A certain amount of the substance is deacetylated or oxidized.
Excretion is carried out through the kidneys – by means of tubular secretion and CF processes. [ 3 ]
Dosing and administration
Using eye drops.
This form of the drug should be used during the first 2 days from the moment the disease develops. The medicine is instilled in the amount of 1-2 drops into the infected eye, with 2-hour breaks (but no more than 8 times per day). After 2 days, the medicine is used in the same portion, but no more than 4 procedures per day.
The duration of the treatment cycle is determined by the nature and severity of the pathology. Usually, its duration is 5 days.
The patient should tilt his head back, then pull down the lower eyelid, drop the medicinal substance, and then close the eyes. To prevent the drug from getting into the lacrimal duct and further into the systemic circulation, it is necessary to pinch the inner edge of the eye with a finger for 60-120 seconds. Blinking is prohibited. The remaining liquid can be removed with a clean napkin (however, it should not come into contact with the eyes).
When using the medicine, do not allow the dropper tip to come into contact with the eyelids or areas near the eye.
If the patient is using any other ophthalmic agent, there should be at least a 15-minute interval between their use with Signicef.
Administration of infusion fluid.
The infusion substance is applied via a dropper, intravenously. The whole procedure is performed at a slow speed – at least 60 minutes. The portion size is 0.25-0.5 g 1-2 times a day, daily. A more precise dosage is selected taking into account the intensity of the disease and its nature.
Dosage ranges for individuals with healthy renal function:
- for sinusitis in the active phase: 0.5 g daily (for a period of 10-14 days);
- active phase of chronic bronchitis: administration of 0.25-0.5 g daily (for a period of 7-10 days);
- urinary tract infections (with or without complications): use 0.25 g daily for 7-10 days. The dose can be increased if necessary;
- lesions of the epidermis and subcutaneous layer: administration of 0.5 g of the drug 2 times a day (the treatment cycle lasts 7-14 days);
- Intra-abdominal infection: 0.5 g of the substance must be used daily (course duration – 7-14 days);
- community-acquired pneumonia: infusion of 0.5 g of liquid 1-2 times per day; the entire course lasts 1-2 weeks;
- chronic stage of bacterial prostatitis: use of 0.5 g of the drug daily for a period of 28 days;
- bacteremia or septicemia: daily administration of 0.5 g of the drug (1-2 times) for 7-14 days;
- combination therapy for drug-resistant forms of tuberculosis: daily infusions of 0.5 g of the drug (1-2 times). The entire cycle lasts about 3 months.
For people with impaired renal function, portion sizes are reduced taking into account the severity of the pathology:
- CC level in the range of 20-50 ml per minute – daily administration of 0.125-0.25 g (1-2 times);
- CC values within 10-19 ml per minute – daily infusion of 0.125 g (1-2 times);
- the CC rate is less than 10 ml per minute – use of 0.125 g of the drug at 1-2 day intervals.
Application for children
In pediatrics, the drug is used very carefully.
Use Cygnicef during pregnancy
Signicef should not be prescribed during pregnancy.
Contraindications
Main contraindications:
- severe intolerance associated with medicinal elements;
- tendon lesions caused by previous treatment with quinolones;
- epilepsy;
- breastfeeding.
Side effects Cygnicef
Negative symptoms are observed only occasionally; they are usually mild to moderate in intensity and disappear after some time. Among the side effects are:
- ophthalmologic disorders: decreased visual acuity, burning or pain in the eye area, erythema or matting affecting the eyelids, papillary conjunctival reaction, itching or swelling of the eyelids, as well as follicles in the conjunctival area, photophobia, chemosis, dry eye mucosa and conjunctival infection;
- immune disorders: anaphylactic or allergic reactions are occasionally observed;
- CNS-related disorders: drowsiness, fear, weakness, dizziness, paresthesia and headaches. In addition, hallucinations, insomnia, seizures, confusion, anxiety, movement disorders and depression;
- respiratory problems: runny nose or thoracic and mediastinal disorders.
- The following negative manifestations may also be observed:
- anorexia, hyperbilirubinemia, increased activity of intrahepatic transaminases, nausea, dysbacteriosis, diarrhea, hepatitis, abdominal pain, vomiting and pseudomembranous enterocolitis;
- hypercreatininemia;
- tachycardia, decreased blood pressure and vascular collapse;
- hypoglycemia;
- disorders of smell, hearing, tactile sensations and taste;
- tendinitis, arthralgia, muscle weakness, rupture affecting tendons, and myalgia;
- tubulointerstitial nephritis;
- agranulocytosis, eosinophilia, thrombocytopenia, leukopenia, neutroopenia or pancytopenia, as well as hemolytic anemia;
- porphyria in the active phase or hemorrhages;
- persistent febrile state, TEN, rhabdomyolysis and superinfection.
Overdose
Intoxication in case of accidental oral ingestion of eye drops is impossible, because the level of levofloxacin in the bottle is extremely low. Overdose with local use can lead to potentiation of side effects.
In this case, you should immediately stop the instillation procedure, then rinse your eyes with warm water. If poisoning occurs after oral administration of the drug, supportive measures are taken.
Interactions with other drugs
The drug prolongs the half-life of cyclosporine.
The effect of Signicef is weakened by substances that slow intestinal motility, as well as sucralfate, antacids (containing Al and Mg) and Fe salts. Therefore, at least a 2-hour break should be observed between their administrations.
The combination of theophylline and NSAIDs leads to increased convulsive readiness, and administration together with GCS increases the likelihood of tendon rupture.
Slowing of excretion of levofloxacin occurs in case of use of cimetidine and agents that slow tubular secretion.
Storage conditions
Signicef must be stored in a place closed to children and sunlight. Do not freeze the drug. Temperature indicators - no higher than 30 ° C.
Shelf life
Signicef can be used within a 2-year period from the date of manufacture of the drug. The shelf life of an already opened bottle is 1 month.
Analogues
Analogues of the drug are Glevo, Levo, Zolev with Oftaquix, Zevocin and Levasept with Abiflox, and also Lebel, Levokatsin, Levokilz and Levobaks. In addition to this, the list includes Levonic, Levobact, Levoximed with Levogrin, Levolet with Levoxa and Levomak with Levoximed. Also mentioned are such drugs as Levoflox, Levotor, Levoflocin with Levofloxacin, Levocel and Levostad, Leflocin and Levofast, Loxof with Levocin and L-Flox with Lefsan. In addition to them - Novox, Leflok, Remedia with Leflocade, Floxium with Potant-Sanovel and Tigeron.
Reviews
Signicef usually receives good reviews from patients - it is believed to demonstrate high therapeutic effectiveness. The only disadvantages noted are the high cost of the drug and the impossibility of its use during lactation and pregnancy.
Attention!
To simplify the perception of information, this instruction for use of the drug "Cygnicef" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.