Signicef

Signicef is an antimicrobial and antibacterial drug that is sold in the form of eye drops and infusion fluid.

The active element of the drug slows down the action of DNA gyrase, as well as topoisomerase IV, and at the same time suppresses DNA binding and prevents supercoiling, as well as cross-linking of breaks in the DNA chain. In addition, the drug is a catalyst for morphological changes inside the bacterial and cell walls, as well as the cytoplasm. [1]

Indications Signicef

It is used for such violations:

• infections that affect the accessory apparatus along with the front of the eye (caused by the influence of bacteria that demonstrate sensitivity to levofloxacin);
• the need to prevent complications that may arise after ophthalmic surgery;
• local treatment of eye infections associated with the action of microbes sensitive to levofloxacin.

Release form

The release of the drug substance is realized in the form of eye drops and a special infusion fluid.

Pharmacodynamics

The drug has an effect on gram-negative and positive aerobes. In addition, it shows a pronounced effect against Chlamydia trachomatis.

The active ingredient of the drug in the form of eye drops accumulates inside the tear film. Its indicators inside the lacrimal fluid quickly become high, being kept at this level within 6 hours. [2]

Pharmacokinetics

After oral administration, the substance is almost completely and at high speed absorbed from the gastrointestinal tract. It penetrates into organs with tissues without complications: bronchial mucosa, lungs, urogenital tract organs, polymorphonuclear leukocytes and alveolar macrophages. Some of the substance is deacetylated or oxidized.

Excretion is realized through the kidneys - by tubular secretion and CF processes. [3]

Dosing and administration

Applying eye drops.

It is necessary to use this form of drugs during the first 2 days from the moment the disease develops. The medication is instilled in the amount of 1-2 drops inside the infected eye, with 2-hour breaks (but no more than 8 times a day). After 2 days, the medicine is used in the same portion, but not more than 4 procedures per day.

The duration of the treatment cycle is determined by the nature and severity of the pathology. It usually lasts 5 days.

The patient needs to tilt his head back, then pull down the lower eyelid, drip the drug, and then close his eyes. To prevent the ingress of drugs into the lacrimal duct and further into the systemic circulation, it is required to hold the inner eye edge with a finger for 60-120 seconds. Blinking is prohibited. You can remove the remainder of the liquid with a clean cloth (while it should not come into contact with the eyes).

During the use of drugs, do not allow the dropper tip to touch the eyelids or areas near the eye.

If the patient uses some other ophthalmic agent, a minimum of 15-minute interval must be maintained between their use with Signicef.

Administration of infusion fluid.

The infusion substance is applied through a dropper, in / in the way. The whole procedure is performed at a slow speed - at least 60 minutes. Serving size - 0.25-0.5 g 1-2 times a day, daily. A more accurate dosage is selected taking into account the intensity of the disease and its nature.

Dosage Sizes in Individuals with Healthy Renal Function:

• with sinusitis in the active phase: 0.5 g daily (in the period of 10-14 days);
• active phase of chronic bronchitis: administration of 0.25-0.5 g daily (in the period of 7-10 days);
• infection of the urethra (with or without complications): the use of 0.25 g daily for 7-10 days. Allowed to increase the portion, if required;
• lesions of the epidermis and subcutaneous layer: the introduction of 0.5 g of drugs 2 times per day (the treatment cycle lasts 7-14 days);
• intra-abdominal infection: requires the use of 0.5 g of the substance daily (course duration - 7-14 days);
• community-acquired pneumonia: infusion of 0.5 g of fluid 1-2 times a day; the whole course lasts 1-2 weeks;
• chronic stage of bacterial prostatitis: use of 0.5 g of medication daily for a period of 28 days;
• bacteremia or septicemia: daily administration of 0.5 g of drugs (1-2 times) for 7-14 days;
• combination therapy for types of tuberculosis resistant to other drugs: daily infusions of 0.5 g of the drug (1-2 times). The whole cycle lasts about 3 months.

For persons with impaired renal function, portion sizes are reduced, taking into account the degree of intensity of the pathology:

• CC level in the range of 20-50 ml per minute - daily administration of 0.125-0.25 g (1-2 times);
• CC values within 10-19 ml per minute - daily infusion of 0.125 g (1-2 times);
• the CC indicator is less than 10 ml per minute - the use of 0.125 g of the drug at 1-2-day intervals.

Application for children

In pediatrics, the medication is used very carefully.

Use Signicef during pregnancy

You can not prescribe Signicef during pregnancy.

Contraindications

The main contraindications:

• severe intolerance associated with drug elements;
• tendon lesions caused by previous treatment with quinolones;
• epilepsy;
• lactation.

Side effects Signicef

Negative signs are noted only occasionally; they usually have mild to moderate intensity and disappear after a while. Among the side symptoms:

• ophthalmic disorders: decreased visual acuity, burning or pain in the eye area, erythema or matting affecting the eyelids, papillary conjunctival reaction, itching or swelling of the eyelids, and in addition follicles in the conjunctival area, photophobia, chemosis, dry ocular mucosa and conjunctival infection;
• immune disorders: anaphylactic or allergic manifestations are occasionally noted;
• lesions associated with the function of the central nervous system: drowsiness, fear, weakness, dizziness, paresthesias and headaches. In addition, hallucinations, insomnia, seizures, confusion, anxiety, movement disorders, and depression;
• respiratory problems: runny nose or thoracic and mediastinal disorders.
• Such negative manifestations may also be noted:
• anorexia, hyperbilirubinemia, increased activity of intrahepatic transaminases, nausea, dysbiosis, diarrhea, hepatitis, abdominal pain, vomiting and pseudomembranous enterocolitis;
• hypercreatininemia;
• tachycardia, decreased blood pressure and vascular collapse;
• hypoglycemia;
• disorders of smell, hearing, tactile sensations and taste;
• tendinitis, arthralgia, muscle weakness, tendon rupture, and myalgia;
• tubulointerstitial nephritis;
• agranulocytosis, eosinophilia, thrombocyto-, leuko-, neutro- or pancytopenia, as well as hemolytic anemia;
• active porphyria or hemorrhage;
• persistent fever, PETN, rhabdomyolysis and superinfection.

Overdose

Intoxication in case of unintentional oral intake of eye drops is impossible, because the level of levofloxacin in the bottle is extremely low. Overdose with local use can lead to the potentiation of side symptoms.

In this case, you must immediately stop the instillation procedure, and then rinse your eyes with warm water. If poisoning occurs after oral administration of drugs, supportive actions are performed.

Interactions with other drugs

The drug prolongs the half-life of cyclosporine.

The effect of Signicef is weakened by substances that slow down intestinal motility, and in addition, sucralfate, antacids (containing Al and Mg) and Fe salts. Therefore, between their introductions, a minimum of 2-hour break should be maintained.

The combination of theophylline and NSAIDs leads to increased convulsive readiness, and administration together with GCS increases the likelihood of tendon rupture.

A slowdown in the excretion of levofloxacin occurs in the case of the use of cimetidine and agents that slow down the secretion of the tubules.

Storage conditions

Signicef must be stored in a place protected from children and sunlight. Do not freeze the drug. Temperature indicators are not higher than the 30 ° C mark.

Shelf life

Signicef can be applied within a 2-year term from the date of manufacture of the medication. The shelf life of an already opened bottle is 1 month.

Analogs

Analogues of drugs are the substances Glevo, Levo, Zolev with Oftaquix, Zevocin and Levasept with Abiflox, and in addition Lebel, Levocacin, Levokils and Levobax. In addition, the list includes Levonik, Levobact, Levoximed with Levogrin, Levolet with Levoxa and Levomak with Levoximed. Also mentioned are such drugs as Levoflox, Levotor, Levofloxin with Levofloxacin, Levocel and Levostad, Leflotsin and Levofast, Loxof with Levocin and L-Phlox with Lefsan. In addition to them - Novox, Leflok, Remedia with Leflokade, Floxium with Potant-Sanovel and Tigeron.

Reviews

Signicef usually receives good reviews from patients - it is believed that it demonstrates high therapeutic efficacy. Of the minuses, only the high cost of the drug and the inability to use it during lactation and pregnancy are noted.