Radelfandrex

Radelfandrex is a tablet drug used to normalize blood pressure and treat hypertension. Let's consider the indications and precautions for using the drug.

The drug belongs to the pharmacotherapeutic group of combined antihypertensive drugs. The drug reduces high blood pressure and is effective in the treatment of arterial hypertension. Today, there are three categories of drugs with a similar mechanism of action:

• Agents with antiadrenergic effect on hemodynamics – a- and b-adrenergic blockers, ganglionic blocking and sympatholytic substances.
• Drugs whose mechanism of action is based on inhibition of RAAS activity or impact on vascular tone. This category includes AT II receptor blockers and angiotensin-converting enzyme inhibitors. Radelfandrex has the same effect.
• Vasodilators – act on calcium and potassium channels of vascular cells and smooth muscle membranes.

Radelfandrex is an effective antihypertensive drug of a combined type. The drug is used only as prescribed by a doctor, strictly observing the dosage and duration of therapy.

Indications Radelfandrex

Indications for use of Radelfandrex are entirely based on the activity of its active ingredients. Tablets are prescribed for the treatment and prevention of such ailments as:

• Hypertension, that is, a persistent increase in blood pressure.
• Psychosis against the background of high blood pressure.
• Mental diseases of vascular etiology.

Antihypertensive treatment is recommended to begin with monotherapy. If the therapeutic effect does not correspond to the expected one, the patient is prescribed combined treatment and the use of several drugs simultaneously. It is advisable to use b-adrenoblockers (cardioselectors) first, as they prevent ischemic disease, have an antiarrhythmic and antianginal effect.

Release form

The drug is available in blister tablets, 50 pieces per package. Physicochemical characteristics of the drug: round, flat, light yellow tablets with a bevel and notch.

Each tablet of the pharmaceutical product contains 0.1 mg of reseprine, 10 mg of dihydralizine sulfate and 10 mg of hydrochlorothiazide. The following are additional components: microcrystalline cellulose, starch, talc, magnesium stearate, lactose, tartrazine yellow and polyvinylpyrrolidone K30.

Pharmacodynamics

Pharmacodynamics Radelfandrex is the mechanism of action of the substances included in the drug. The combined antihypertensive drug contains three active components, let's consider them:

• Reserpine - depletes the catecholamine depot in the postganglionic sympathetic nerve fibers. Due to this, a sedative reaction occurs, i.e. the work of the heart muscle, sympathetic nervous system and peripheral vascular resistance decreases.
• Hydrochlorothiazide is a substance from the class of thiazide diuretics of moderate effectiveness. It affects the epithelium of the renal tubules, inhibits the reabsorption of chlorine and sodium ions. Due to this, calcium reabsorption increases and after 2-4 hours a diuretic effect is observed, the duration of which can reach 12 hours. Does not cause reflex tachycardia.
• Dihydralazine sulfate - reduces the tone of smooth muscles of arterial vessels, reduces vascular resistance. Long-term use does not cause a decrease in renal blood flow.

Pharmacokinetics

Pharmacokinetics of Radelphandrex are the processes of absorption, metabolism and excretion of its active components.

• Reserpine - after oral administration, it is rapidly absorbed, bioavailability is 60%, and plasma protein binding is 87%. It is rapidly metabolized. The half-life is 4-5 hours, complete elimination occurs after 96 hours. It is excreted in urine, feces and breast milk.
• Hydrochlorothiazide is absorbed by 60-80%, the maximum concentration in the blood plasma occurs after 2-3 hours, protein binding is at the level of 70%. The half-life in patients with normal renal function is 2 hours. 60-75% of the dose taken is excreted unchanged in the urine.
• Dihydralazine sulfate is rapidly absorbed, the maximum concentration in plasma occurs 2 hours after administration, protein binding is 70-90%. Metabolized in the liver, excreted by the kidneys as metabolites, half-life is 2-3 hours.

Dosing and administration

The method of administration and dosage are selected individually for each patient. The tablets are taken orally before or after meals. The recommended dosage is 1 tablet 3 times a day. If necessary, the dosage is increased to two tablets three times a day.

If the drug is prescribed to normalize blood pressure in the early stages, then patients are prescribed 1 tablet 2-3 times a day. If no improvement is observed, then the dosage is increased to 3 tablets. But if the hypotensive effect is not observed within 14 days, then the drug is discontinued by lowering the dosage. To prevent high blood pressure, patients are prescribed 1 tablet once a day, the duration of treatment is 2-3 months under the supervision of a doctor.

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Use Radelfandrex during pregnancy

The use of Radelfandrex during pregnancy is prohibited, as the category of action on the fetus according to the FDA is category C. This category indicates that the drug was studied only in animals, and a negative effect on the fetus was found. Clinical studies for pregnant women have not been conducted, but the potential benefit to the woman may justify the risks to the unborn child.

Since vasodilation processes predominate in early pregnancy (up to 20 weeks), mild arterial hypertension does not require medication. When using any medications, intensive monitoring of the fetus and the mother's body is required, regardless of the success of treating high blood pressure. But when using pills, a pregnant woman should be aware of the risk of seizures, miscarriage, and disseminated intravascular coagulation.

Contraindications

Contraindications to the use of Radelfandrex depend on the body's reaction to the active components of the pharmaceutical product. The drug is not used for diseases such as:

• Individual intolerance and hypersensitivity to active substances.
• Severe cardiovascular diseases.
• Peptic ulcer disease.
• Lesions of the duodenum, stomach and kidneys (if function is impaired).
• Depression.
• Bronchial asthma.
• Systemic lupus erythematosus.
• Pregnancy and lactation period.
• Parkinsonism.
• Gout and diabetes mellitus (severe forms).
• Pronounced atherosclerotic changes in blood vessels.

Side effects Radelfandrex

Side effects of Radelfandrex may occur if the recommended dosage is not followed. Most often, patients complain of nausea, vomiting and diarrhea, in isolated cases the drug causes pancreatitis. From the cardiovascular system, tachycardia and orthostatic hypotension are possible.

The drug may cause hypokalemia, hypercalcemia, hypomagnesemia and hyperglycemia. Rarely, thrombocytopenia and neutropenia, visual impairment occur. In rare cases, allergic reactions occur, i.e. dermatitis. In addition, the drug causes a number of side effects from the peripheral and central nervous system, this is increased fatigue, dizziness, paresthesia, weakness, headaches.

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Overdose

Overdose is possible with prolonged use of tablets or failure to comply with the recommended dose. The main symptoms are: dizziness, headache, drowsiness, convulsions, miosis, extrapyramidal disorders, nausea, vomiting, diarrhea, loss of consciousness, hypotension.

To eliminate adverse symptoms, it is necessary to wash out the stomach, take an absorbent (activated carbon) or induce vomiting. If convulsions occur, then intravenous administration of diazepam is required. In case of hypotension, the patient is given plasma substitutes.

Interactions with other drugs

Interaction of Radelfandrex with other drugs is possible with appropriate medical permission. The drug enhances the effect of other antihypertensive drugs and underpolarizing muscle relaxants, increases the concentration of lithium salts in the blood to a toxic level. Radelfandrex is not recommended for use with non-steroidal anti-inflammatory drugs, since such interaction increases the risk of developing hemodynamic renal failure.

When used simultaneously with diazepam, barbiturates or ethanol, there is an increased risk of orthostatic hypotension. When used with glucocorticosteroids, increased excretion of potassium ions from the body is possible. The active substances reduce the activity of oral hypoglycemic agents.

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Storage conditions

Storage conditions of Radelfandrex correspond to the norms and rules for storing tablet preparations. The medicine should be kept in a dry place, protected from direct sunlight and inaccessible to children.

The medicine must be in its original packaging. The required storage temperature is from 8 to 25 °C. If the above recommendations are not followed, the medicine loses its pharmaceutical properties and is dangerous to use.

Shelf life

The shelf life of the drug is 36 months from the date of manufacture. After its expiration, the drug must be disposed of, since its use may cause uncontrolled side effects on all organs and systems of the body.