Radelfandreks

Radelfandrex is a tablet preparation used to normalize blood pressure and treat hypertension. Consider the indications and methods of precautions for using the drug.

Medication refers to the pharmacotherapeutic group of combined antihypertensive drugs. The drug reduces hypertension and is effective in the treatment of hypertension. To date, there are three categories of drugs with a similar mechanism of action:

• Means with antiadrenergic effect on hemodynamics - a- and b-adrenoblockers, ganglion blocking and sympatholytic substances.
• Drugs, the mechanism of action of which is based on inhibition of RAAS activity or effects on vascular tone. This category includes AT II receptor blockers and angiotensin converting enzyme inhibitors. Radelfandrex has the same action.
• Vasodilators - act on the calcium and potassium channels of vascular cells and smooth muscle membranes. 

Radelfandrex is an effective antihypertensive agent of a combined type. The medication is used only for medical purposes, strictly observing the dosage and duration of therapy.

Indications Radelfandreks

Indications for the use of Radelfandrex are completely based on the activity of its active ingredients. Tablets are prescribed for the treatment and prevention of such ailments as:

• Hypertensive disease, that is, a steady rise in blood pressure.
• Psychoses against the background of high blood pressure.
• Mental diseases of vascular etiology.

Antihypertensive treatment is recommended to begin with monotherapy. If the therapeutic effect does not match the expected, the patient is prescribed combined treatment and the use of several drugs at the same time. First it is desirable to use b-adrenoblockers (cardioselectors), as they prevent ischemic disease, have antiarrhythmic and antianginal effect.

Release form

The form of the drug - tablets in blisters, in one package of 50 pieces. Physico-chemical characteristics of the drug: round, flat, light-yellow tablets with a facet and a notch.

Each tablet of a pharmaceutical agent contains 0.1 mg of reseprin, 10 mg of dihydralysin sulfate, and 10 mg of hydrochlorothiazide. As additional components are: microcrystalline cellulose, starch, talc, magnesium stearate, lactose, tartrazine yellow and polyvinylpyrolidone K30.

Pharmacodynamics

Pharmacodynamics Radel'fandreks is a mechanism of action of the substances that make up the medicinal product. Combined antihypertensive drug contains three active components, consider them:

• Reserpine - depletes the depot of catecholamines in postganglionic sympathetic nerve fibers. Thanks to this, a sedative reaction occurs, that is, the work of the heart muscle, the sympathetic nervous system and peripheral vascular resistance decreases.
• Hydrochlorothiazide is a substance from the class of thiazide diuretics of medium effectiveness. Affects the epithelium of the renal tubules, inhibits the reabsorption of ions of chlorine and sodium. Thanks to this, calcium reabsorption is increased and after 2-4 hours diuretic effect is observed, the duration of which can reach 12 hours. Does not cause reflex tachycardia.
• Dihydralazine sulfate - lowers the tone of the smooth muscles of the arteries, reduces vascular resistance. Long-term use does not cause a decrease in renal blood flow.

Pharmacokinetics

The pharmacokinetics of Radelfandrex are the processes of absorption, metabolism and excretion of its active components.

• Reserpine - after oral administration is rapidly absorbed, bioavailability at 60%, and binding to plasma proteins 87%. Rapidly metabolized. The half-life period is 4-5 hours, complete elimination occurs after 96 hours. It is excreted in urine, feces and breast milk.
• Hydrochlorothiazide - absorbed by 60-80%, the maximum concentration in the blood plasma comes in 2-3 hours, the binding with proteins at 70%. Half-life in patients with normal renal function is 2 hours. 60-75% of the accepted dose is excreted unchanged in the urine.
• Dihydralazine sulfate - quickly absorbed, the maximum concentration in the plasma occurs after 2 hours after ingestion, the binding to proteins at a level of 70-90%. Metabolized in the liver, excreted by the kidneys in the form of metabolites, half-life 2-3 hours.

Dosing and administration

The way of application and dose is selected individually for each patient. Tablets are taken orally before or after a meal. The recommended dosage is 1 tablet 3 times a day. If necessary, increase the dosage to two tablets three times a day.

If the drug is prescribed to normalize blood pressure in the early stages, then patients are prescribed 1 tablet 2-3 times a day. If no improvement is observed, the dosage is increased to 3 tablets. But if the antihypertensive effect is not observed within 14 days, then the medicine is canceled by lowering the dosage. For prevention of high blood pressure, patients are prescribed 1 tablet once per knock, duration of treatment 2-3 months under the supervision of a doctor.

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Use Radelfandreks during pregnancy

The use of Radelfandrax during pregnancy is prohibited, because the category of action on the fetus is FDA-C. This category indicates that the study of the drug was carried out only in animals, and a negative effect on the fetus was detected. Clinical studies for pregnant women have not been conducted, but the potential benefit for a woman can justify the risks for a child's future.

Since the early stages of pregnancy (up to 20 weeks) are dominated by vasodilation processes, the mild degree of hypertension does not require the use of medications. When using any drugs, intensive monitoring of the fetal and maternal conditions is required, regardless of the success of treatment of high blood pressure. But applying the pill, the pregnant woman should know about the risk of seizures, miscarriage and disseminated intravascular coagulation.

Contraindications

Contraindications to the use of Radelfandrex depend on the reaction of the body to the active components of the pharmaceutical. The medicine is not used for such diseases as:

• Individual intolerance and hypersensitivity to active substances.
• Severe diseases of the cardiovascular system.
• A peptic ulcer.
• Lesions of the duodenum, stomach and kidneys (in case of impaired function).
• Depression.
• Bronchial asthma.
• Systemic lupus erythematosus.
• Pregnancy and lactation.
• Parkinsonism.
• Gout and diabetes (severe forms).
• Severe atherosclerotic vascular changes.

Side effects Radelfandreks

Side effects of Radelfandrex can occur if the recommended dosage is not observed. Most often, patients complain of nausea, vomiting and diarrhea, in a few cases, the medication becomes the cause of pancreatitis. From the side of the cardiovascular system, tachycardia and orthostatic hypotension are possible.

The medicine can cause hypokalemia, hypercalcemia, hypomagnesemia and hyperglycemia. Rarely there is thrombocytopenia and neutropenia, visual impairment. In rare cases, there are allergic reactions, that is, dermatitis. In addition, the drug causes a number of side effects from the peripheral and central nervous system, it is increased fatigue, dizziness, paresthesia, weakness, headaches.

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Overdose

Overdose is possible with prolonged use of tablets or non-compliance with the recommended dose. The main symptoms: dizziness, headache, drowsiness, convulsions, miosis, extrapyramidal disorder, nausea, vomiting, diarrhea, loss of consciousness, hypotension.

To eliminate adverse symptoms, it is necessary to wash the stomach, take absorbent (activated charcoal) or induce vomiting. If there are cramps, then intravenous diazepam is required. When hypotension, the patient is administered plasma substitutes.

Interactions with other drugs

The interaction of Radelfandrex with other drugs is possible with the appropriate medical clearance. The drug enhances the effect of other antihypertensive medications and nonpolarizing myorexantans, raises the concentration of lithium salts in the blood to a toxic level. Radelfandrax is not recommended for use with non-steroidal anti-inflammatory drugs, since such interaction increases the risk of hemodynamic renal failure.

With simultaneous use with diazepam, barbiturates or ethanol, there is an increased risk of orthostatic hypotension. When used with glucocorticosteroids, it is possible to increase the excretion of potassium ions from the body. Active substances reduce the activity of oral hypoglycemic agents.

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Storage conditions

The storage conditions of Radelfandrex correspond to the norms and rules for storage of tableted preparations. The medicine should be kept in a dry place, protected from direct sunlight and out of reach of children.

The medication must be in its original packaging. The required storage temperature is from 8 to 25 ° C. If the above recommendations are not followed, the drug loses its pharmaceutical properties and is dangerous to use.

Shelf life

Shelf life 36 months from the date of production. At its expiration, the medicine must be disposed of, since application can cause uncontrolled side effects on the part of all organs and systems of the body.