Radedorm 5

Radedorm 5 - a tool used in the treatment and prevention of sleep disorders. Consider the characteristics of the drug, indications for its use, possible side effects and therapeutic effect.

The drug refers to the pharmacological group of sleeping pills that fight with sleep disorders and awakening of different genesis. The medication helps to cope with the difficulty of falling asleep, night awakenings and pathologies of the nervous system that provoke frustration.

Radedorm 5 refers to effective sleeping pills used to treat and prevent sleep and nervous system problems. For today, several preparations of analogues are isolated, with a similar principle of action. These drugs include: Nitrazepam, Nitrosan, Eunotin. Drugs are only available on prescription.

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Indications Radedorm 5

Radedorm 5 is based on the effectiveness of its active ingredients and their effect on the body. Tablets are used for therapy and prevention of sleep disorders. They can be used as part of a combination therapy for encephalopathy, accompanied by epileptic myoclonic seizures.

The medication is prescribed for the treatment of the prophylaxis of infantile spasms or lightning-fast nodal salamative convulsions in children of children, that is, in children from 4 months to 1-2 years. It is effective in the complex therapy of neuroses, chronic alcoholism, psychopathy, premedication, organic lesions of the central nervous system and endogenous psychoses.

Release form

Form of release of sleeping pills - oral tablets, coated with a shell. Each blister has 10 tablets, one package contains one blister. This form simplifies the process of taking, as the patient has the opportunity to calculate the dosage and the amount needed for treatment.

One tablet contains 5 mg of active ingredient - nitrazepam. Additional substances are: magnesium stearate, microcrystalline cellulose, lactose and sodium starch. The sedative refers to benzodiazepine derivatives and is dispensed by a prescription.

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Pharmacodynamics

Pharmacodynamics Radedorm 5 indicates that the drug has anticonvulsant, centrally myorelaxing and anxiolytic effects. The active substance enhances the inhibitory effect of the mediator of pre- and postsynaptic inhibition in all parts of the central nervous system for impulse transmission. The drug intake promotes the stimulation of benzodiazepine receptors, which are located in the allosteric center of GABA, responsible for the activity of the reticular formation of the brain stem and neurons of the spinal cord. This reduces the excitability of the limbic system, the hypothalamus and the thalamus, that is, the subcortical structures of the brain, and also inhibits polysynaptic spinal reflexes.

• The hypnotic effect arises from the oppression of the cells of the reticular formation of the brain. This reduces the effect of stimuli (emotional, motor, vegetative), disturbing the process of falling asleep. The duration and depth of sleep increases, the awakening becomes physiological.
• Anticonvulsant action is manifested due to increased presynaptic inhibition. Suppression of epileptogenic activity without affecting the focus of excitation is observed. The action begins 30-40 minutes after the prim and lasts for 6-8 hours. Perhaps a slight inhibition of muscle functions and motor nerves.
• The anxiolytic effect is manifested due to the effect on the almond-like complexes of the limbic system and causes a decrease in emotional tension, stress, anxiety, anxiety. The sedative effect reduces the symptoms of neurotic origin, that is, anxiety and fear.

Pharmacokinetics

Pharmacokinetics Radedorm 5 is the absorption, distribution and excretion of a drug. Nitrazepam is rapidly absorbed, the maximum concentration in the blood plasma is observed after 30-120 minutes after application. Simultaneous intake of food and tablets reduces the maximum concentration by 30%. The distribution phase varies from 2-3.5 hours. Binding to blood proteins 85%.

The half-life takes up to 30 hours, the hepatic elimination is slow. About 1% of the drug is excreted unchanged in the urine. Daily use of the drug over a long period of time leads to a cumulation of nitrazepam. Bioavailability for oral use is 55-98%.

Dosing and administration

The method of administration and dose are indicated by the attending physician, individually for each patient. Tablets are taken orally for 30-40 minutes before bedtime. Adults appoint 5-10 mg, elderly patients 2.5-5 mg each. The medicine can also be prescribed for children. Patients up to a year of 1.25-2 mg, from 1 to 6 years of 2.5-5 mg and from 6 to 14 years, 5 mg at bedtime.

The maximum daily dose should not exceed 20 mg for adults and 5 mg for children. If the patient has contraindications or if there are side effects from sleeping pills, then a review of the dosage and observation by the doctor is required.

Use Radedorm 5 during pregnancy

Use Radedorm 5 during pregnancy is contraindicated. The active substance passes through the placental and blood-brain barrier, therefore it is not recommended for use during the period of gestation and lactation. When used in the first trimester, teratogenicity, respiratory failure and suppression of the sucking reflex in newborns are possible.

The use of pills during pregnancy is permitted if the benefit to the mother is more important than the potential risk to the fetus. During treatment it is necessary to refuse breastfeeding and to be observed at the attending physician.

Contraindications

Radedorm 5 completely depends on the individual characteristics of the patient's body. Tablets are not used for hypersensitivity to their constituents. Acute alcohol intoxication, drug poisoning, drug addiction, coma, shock, myasthenia gravis, temporal epilepsy, angle-closure glaucoma, are a prohibition against the use of medication.

Tablets are not prescribed to patients in a state of severe depression, with swallowing, acute respiratory failure, hypercapnia. Use with caution in renal and hepatic insufficiency, organic brain diseases, psychosis and cerebral or spinal ataxia.

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Side effects Radedorm 5

Side effects of Radedorm 5 are manifested when non-compliance with the indications for the use of sleeping pills.

• Nervous system: drowsiness, increased fatigue, headaches and dizziness. Perhaps the slowing of mental and motor reactions, depression of mood, depressive state, tremor of extremities. In rare cases, paradoxical reactions arise, that is, aggressive flashes, suicidal tendencies, insomnia, irritability and anxiety.
• Genitourinary system: delay and incontinence, increased or decreased libido, allergic reactions, impaired renal function.
• Organs of hematopoiesis: hyperthermia, leukopenia, anemia, thrombocytopenia.
• Digestive system: nausea, vomiting, impaired liver function (increased activity of transaminases), jaundice, dry mouth and increased salivation.

In addition to the above-described side effects with prolonged use comes the addiction, that is, drug dependence. Rarely - violation of respiratory functions and vision, weight loss, high blood pressure. Discontinuation or a sharp decrease in dose provokes withdrawal syndrome. In this case, patients complain of increased irritability, headaches, spasms of the muscular system, nausea, vomiting, limb tremors and other symptoms.

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Overdose

Overdose manifests as drowsiness, confusion, decreased reflexes and reactions to painful stimuli. An increased dose can cause deep sleep, visual impairment, shortness of breath and shortness of breath. In rare cases, a respiratory coma, a decrease in blood pressure, and a suppression of cardiac function are possible.

Treat an overdose of gastric lavage. In addition, it is recommended to take absorbent, for example, activated charcoal and conduct forced diuresis. If adverse manifestations persist for several days, symptomatic therapy, ie control of blood pressure and maintenance of breathing, is performed. In particularly difficult cases, an antidote, flumazenil, is used, but only in a hospital setting. Hemodialysis is not carried out, since it is ineffective.

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Interactions with other drugs

The interaction of Radedorm 5 with other drugs is possible with appropriate medical indications. The medication reduces the effectiveness of levodopa if it is prescribed to patients with Parkinson's disease. Use with psychoactive and narcotic drugs, anesthetics, sedatives and antihistamines increases their effect. The drug enhances and lengthens the effect of oral estrogen-containing contraceptives and cimetidine.

When used with microsomal oxidation inhibitors, the risk of toxic side effects is significantly increased. The active substance loses its effectiveness when interacting with inducers of microsomal enzymes of the liver. Taking narcotic analgesics leads to drug dependence and enhances the effect of euphoria. When used with antihypertensive drugs, blood pressure decreases, so medical attention is required.

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Storage conditions

Storage conditions Radedorm 5 are listed in the instructions of the pharmaceutical product. Sleeping pills should be kept out of the sunlight and out of the reach of children. The temperature should not exceed 25 ° C.

If the above rules are not observed, the medicament loses its medicinal properties and is prohibited for use. Tablets should be stored only in the original packaging.

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Shelf life

Shelf life is 60 months from the production date indicated on the package. At the end of this period, the medicine must be disposed of and prohibited from taking.

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