Radedorm 5

Radedorm 5 is a drug used in the treatment and prevention of sleep disorders. Let's consider the features of the drug, indications for its use, possible side effects and therapeutic effect.

The medicine belongs to the pharmacological group of sleeping pills that combat sleep and awakening disorders of various genesis. The medicine helps to cope with difficulty falling asleep, night awakenings and pathologies of the nervous system that provoke the disorder.

Radedorm 5 is an effective sleeping pill used to treat and prevent sleep and nervous system problems. Today, there are several analog drugs with a similar principle of action. These drugs include: Nitrazepam, Nitrosan, Eunoktin. The drugs are available only by prescription.

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Indications Radedorm 5

Radedorm 5 is based on the effectiveness of its active ingredients and their effect on the body. The tablets are used for the treatment and prevention of sleep disorders. They can be used as part of combination therapy for encephalopathy accompanied by epileptic myoclonic seizures.

The medicine is prescribed for the treatment and prevention of infantile spasms or lightning-fast nodding Salaam convulsions in pediatric patients, i.e. in children from 4 months to 1-2 years. It is effective in the complex therapy of neuroses, chronic alcoholism, psychopathy, premedication, organic lesions of the central nervous system and endogenous psychoses.

Release form

The sleeping pill is available in oral coated tablets. Each blister contains 10 tablets, one blister per package. This form simplifies the intake process, as the patient has the opportunity to calculate the dosage and quantity needed for treatment.

One tablet contains 5 mg of the active substance - nitrazepam. Additional substances are: magnesium stearate, microcrystalline cellulose, lactose and sodium starch. The sedative is a benzodiazepine derivative and is available on prescription.

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Pharmacodynamics

Pharmacodynamics of Radedorm 5 indicates that the drug has anticonvulsant, central muscle relaxant and ansiolytic effects. The active substance enhances the inhibitory effect of the mediator of pre- and postsynaptic inhibition in all parts of the central nervous system on the transmission of impulses. Taking the drug promotes stimulation of benzodiazepine receptors, which are located in the allosteric center of GABA, responsible for the activity of the reticular formation of the brain stem and neurons of the spinal cord. This reduces the excitability of the limbic system, hypothalamus and thalamus, i.e. the subcortical structures of the brain, and also inhibits polysynaptic spinal reflexes.

• The hypnotic effect occurs due to the suppression of the cells of the reticular formation of the brain. This reduces the impact of irritants (emotional, motor, vegetative) that disrupt the process of falling asleep. The duration and depth of sleep increases, awakening becomes physiological.
• The anticonvulsant effect is due to increased presynaptic inhibition. Suppression of epileptogenic activity is observed without affecting the excitation center. The effect begins 30-40 minutes after administration and lasts for 6-8 hours. Minor inhibition of muscle functions and motor nerves is possible.
• The anxiolytic effect is due to the impact on the amygdala complexes of the limbic system and causes a decrease in emotional tension, stress, anxiety, and worry. The sedative effect reduces symptoms of neurotic origin, that is, anxiety and fear.

Pharmacokinetics

Pharmacokinetics of Radedorm 5 is the absorption, distribution and excretion of the drug. Nitrazepam is rapidly absorbed, the maximum concentration in the blood plasma is observed 30-120 minutes after administration. Simultaneous intake of food and tablets reduces the maximum concentration by 30%. In this case, the distribution phase varies from 2-3.5 hours. Binding to blood proteins is 85%.

The half-life is up to 30 hours, liver elimination is slow. About 1% of the drug is excreted unchanged in the urine. Daily use of the drug over a long period of time leads to accumulation of nitrazepam. Bioavailability when taken orally is 55-98%.

Dosing and administration

The method of administration and dosage are specified by the attending physician, individually for each patient. The tablets are taken orally 30-40 minutes before bedtime. Adults are prescribed 5-10 mg, elderly patients 2.5-5 mg. The medicine can also be prescribed to children. Patients under one year old are prescribed 1.25-2 mg, from 1 to 6 years old 2.5-5 mg and from 6 to 14 years old 5 mg before bedtime.

The maximum daily dose should not exceed 20 mg for adults and 5 mg for children. If the patient has contraindications or side effects from the sleeping pill, then the dosage must be reviewed and the doctor must monitor it.

Use Radedorm 5 during pregnancy

The use of Radedorm 5 during pregnancy is contraindicated. The active substance passes through the placental and blood-brain barriers, so it is not recommended for use during pregnancy and lactation. When used in the first trimester, teratogenicity, respiratory failure and suppression of the sucking reflex in newborns are possible.

The use of tablets during pregnancy is permitted in cases where the benefit to the mother is significantly more important than the potential risk to the fetus. During treatment, it is necessary to stop breastfeeding and be monitored by the attending physician.

Contraindications

Radedorm 5 completely depend on the individual characteristics of the patient's body. Tablets are not used in case of hypersensitivity to their components. Acute alcohol intoxication, poisoning with drugs, drug addiction, coma, shock, myasthenia, temporal epilepsy, closed-angle glaucoma are a ban on the use of the drug.

Tablets are not prescribed to patients with severe depression, swallowing disorders, acute respiratory failure, hypercapnia. Use with caution in renal and hepatic failure, organic brain diseases, psychosis and cerebral or spinal ataxia.

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Side effects Radedorm 5

Side effects of Radedorm 5 occur when the indications for the use of the sleeping pill are not followed.

• Nervous system: drowsiness, increased fatigue, headaches and dizziness. Possible slowing of mental and motor reactions, depressed mood, depressive state, tremor of the limbs. In rare cases, paradoxical reactions occur, i.e. aggressive outbursts, suicidal tendencies, insomnia, irritability and anxiety.
• Urogenital system: urinary retention and incontinence, increased or decreased libido, allergic reactions, impaired renal function.
• Hematopoietic organs: hyperthermia, leukopenia, anemia, thrombocytopenia.
• Digestive system: nausea, vomiting, liver dysfunction (increased transaminase activity), jaundice, dry mouth and increased salivation.

In addition to the above-described side effects, addiction occurs with prolonged use, i.e. drug dependence. Rarely - respiratory and vision impairment, weight loss, high blood pressure. Stopping the intake or sharply reducing the dose provokes withdrawal syndrome. In this case, patients complain of increased irritability, headaches, muscle spasms, nausea, vomiting, tremors of the limbs and other symptoms.

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Overdose

Overdose manifests itself as drowsiness, confusion, decreased reflexes and reactions to painful stimuli. An increased dose can cause deep sleep, visual impairment, shortness of breath and difficulty breathing. In rare cases, respiratory coma, decreased blood pressure and suppression of cardiac function are possible.

Overdose is treated by gastric lavage. In addition, it is recommended to take an absorbent, for example, activated carbon, and perform forced diuresis. If adverse effects persist for several days, symptomatic therapy is performed, that is, monitoring blood pressure and maintaining breathing. In particularly difficult cases, an antidote is used - flumazenil, but only in a hospital setting. Hemodialysis is not performed, as it is ineffective.

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Interactions with other drugs

Interaction of Radedorm 5 with other drugs is possible with appropriate medical indications. The drug reduces the effectiveness of levodopa if it is prescribed to patients with Parkinsonism. Use with psychoactive and narcotic drugs, anesthetics, sedatives and antihistamines enhances their effect. The drug enhances and prolongs the effect of oral estrogen-containing contraceptives and cimetidine.

When used with microsomal oxidation inhibitors, the risk of toxic side effects increases significantly. The active substance loses its effectiveness when interacting with inducers of liver microsomal enzymes. Taking narcotic analgesics leads to drug dependence and increases the effect of euphoria. When used with antihypertensive drugs, the decrease in blood pressure increases, so medical supervision is required.

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Storage conditions

Storage conditions for Radedorm 5 are specified in the instructions for the pharmaceutical product. The sleeping pill must be kept in a place protected from sunlight and out of reach of children. The temperature should not exceed 25 °C.

If the above rules are not followed, the medicine loses its medicinal properties and is prohibited for use. Tablets should be stored only in the original packaging.

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Shelf life

The shelf life of the sleeping pill is 60 months from the production date indicated on the package. After this period, the medicine must be disposed of and is prohibited for use.

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