Rabelock

Rabelok is a medicine with antiulcer properties. Let's consider the indications for its use, dosage, possible side effects and other medicinal properties.

International name – Rabeprazole, manufactured in India by Cadila Pharmaceuticals Ltd. Pharmacotherapeutic group of the drug – proton pump inhibitors. The drug affects the digestive system and is used to treat acid-dependent diseases.

The antiulcer agent is an inhibitor of H ⁺ -K ⁺ -ATPase. The mechanism of action is based on the inhibition of enzymes in the parietal gastric cells. This blocks the final stage of hydrochloric acid formation. The effect is dose-dependent and entails inhibition of hydrochloric acid secretion (stimulated and basal).

Rabelok is an effective antiulcer drug, available only with a doctor's prescription. Before taking the drug, a doctor's consultation and examination of the digestive organs are required.

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Indications Rabelock

Rabelok is a treatment and prevention (in the acute phase) of duodenal and gastric ulcer. The drug is effective in gastroesophageal reflux and gastrointestinal diseases associated with Helicobacter pylori (in combination with antibiotics).

Before using it, it is necessary to undergo a medical examination and exclude possible oncological lesions of the stomach and digestive organs. This is due to the fact that the use of the drug can mask pathological symptoms, which will significantly delay the correct diagnosis and complicate further treatment. If the tablets are taken by patients with impaired liver or kidney function, the dosage is not adjusted. But in case of severe disorders, the drug is taken only under medical supervision.

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Release form

The drug is available in enteric-coated tablets. The tablets contain 10 and 20 mg of the active substance. Each pack contains 1 blister of 10 capsules.

In addition to tablets, there is Rabelok lyophilisate for infusion solution of 20 mg in bottle No. 1. This form is prescribed to patients who cannot take the drug orally.

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Pharmacodynamics

Pharmacodynamics of Rabelok is information about the mechanism of action of the active components of the drug. The active substance is a proton pump inhibitor and inhibits the activity of the enzyme H + K + - ATPase. This occurs in the parietal gastric cells and stops the formation of hydrochloric acid at the last stage. This effect is dose-dependent, since regardless of the irritant, it entails inhibition of hydrochloric acid secretion.

By means of a covalent bond, rabeprazole binds to the proton pump in parietal cells, causing an irreversible decrease in the secretion of hydrochloric acid. That is, the kinetics of the active component in the blood plasma does not affect the antisecretory effect, but increases the biological activity and the half-life (20-24 hours).

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Pharmacokinetics

Pharmacokinetics of Rabelok are the processes that occur with the components of the drug after administration. The active substance is quickly absorbed from the gastrointestinal tract. If a dose of 20 mg is taken, the maximum concentration is reached in 3-4 hours, changes in concentration depend on the dosage and are linear. Bioavailability is 52% and does not increase with repeated administration. Time of administration and food intake do not affect the absorption process.

Plasma protein binding is 97%, metabolized in the liver. About 90% is excreted in the urine as metabolites (carboxylic acid, mercaptopuric acid conjugate), the remaining 10% is excreted in the feces. If Rabelok is taken by elderly patients, the excretion of rabeprazole is slowed down.

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Dosing and administration

The method of administration and dosage are selected by the doctor, individually for each patient. A single dose is considered to be 10-20 mg of rabeprazole. The duration and frequency of use depend on the treatment regimen and indications for use.

• For peptic ulcer of the stomach and peptic ulcer disease, 20 mg is prescribed 1-2 times a day for 2-8 weeks.
• For non-ulcer dyspepsia – 40 mg once a day or 20 mg twice a day for 2-4 weeks.
• For the treatment of Zollinger-Ellison syndrome, 20-60 mg per day is prescribed. If necessary, the dosage can be increased to 120 mg per day, the duration of therapy is 2-8 weeks.
• Chronic gastritis in the acute stage is treated by taking 40 mg per day, the course of treatment is 2-4 weeks.
• If the tablets are used for the eradication of H. pylori, the optimal treatment regimen is determined by the attending physician. As a rule, patients are prescribed 20 mg twice a day in combination with other antibiotics.

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Use Rabelock during pregnancy

The use of Rabelok during pregnancy is contraindicated. According to experimental studies, rabeprazole penetrates the placental barrier in small quantities. But this does not cause fertility disorders and fetal development defects. The substance is excreted in breast milk, so when using it, it is necessary to stop the lactation process.

The drug is not prescribed to pediatric patients, since to date there is no experience of its use in this group of patients.

Contraindications

Contraindications to the use of Rabelok are based on the mechanism of action of its active components in relation to all organs and systems of the patient's body. Tablets and infusions are not used in such cases:

• Pregnancy and lactation
• Individual intolerance to the components of the medication
• Hypersensitivity to substituted benzimidazoles
• Oncological diseases of the digestive organs and gastrointestinal tract.

Side effects Rabelock

Side effects of Rabelok are possible if the recommended dosage is not followed or the treatment period is exceeded. Rabelok is well tolerated, the side effects are mild or moderate, but reversible. Most often, patients complain of headaches, nausea and diarrhea. Let's consider the side effects from all organs and systems of the body:

• Digestive system – abdominal pain, vomiting, bloating, nausea, belching. In isolated cases, constipation, dry mouth, gastritis, stomatitis and increased activity of liver transaminases occur.
• Central and peripheral nervous system – headaches and dizziness, insomnia, nervousness, drowsiness. In rare cases, visual and taste disturbances, depression are possible.

• Respiratory system – cough, rhinitis, pharyngitis.

In addition to the symptoms described above, allergic reactions (skin rash and itching), back and chest pain, calf muscle cramps, chills, fever, urinary tract infections and increased sweating are possible.

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Overdose

Overdose occurs when recommendations regarding indications for use and dosage are not followed.

Symptoms:

• Increased sweating
• Dizziness
• Headaches
• Drowsiness
• Dry mouth
• Nausea
• Vomit

To eliminate the above symptoms, supportive symptomatic treatment is carried out. If the overdose is severe, then you should stop taking Rabelok and seek medical help to adjust the dose or select a safer analog drug.

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Interactions with other drugs

Interaction of Rabelok with other drugs is possible with a comprehensive approach to treatment. Let's consider the most common reactions of rabeprazole when interacting with various drugs:

• When used with digoxin, its increased concentration in the blood plasma is observed, therefore, a dose adjustment is required.
• Ketoconazole reduces the bioavailability of rabeprazole.
• No interactions are observed when used simultaneously with antacids.
• When atazanavir, ritonavir, omeprazole or lansoprazole are co-administered, there is a decrease in atazanavir exposure, but absorption remains normal.

The active substance provides long-term and pronounced inhibition of gastric acid secretion. The drug normally interacts with drugs, the absorption of which directly depends on the pH of the stomach contents.

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Storage conditions

Storage conditions for Rabelok correspond to the rules for storing other tablet medications. Rabelok should be kept in a dry place, inaccessible to children and protected from sunlight. The temperature should be within 25 °C.

If Rabelok is used as an infusion solution, the prepared solution can be stored for no more than 4 hours at room temperature and no more than 24 hours if stored in the refrigerator. If the color or smell changes, the medication must be discarded and should not be taken.

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Shelf life

The expiration date is 24 months from the production date, which is indicated on one side of the medicine package. After its expiration, the medicine is prohibited to take, as uncontrolled side effects are possible.